Preferential association between childhood emotional abuse and bipolar disorder

Étain, Bruno; Mathieu, Flavie; Henry, Chantal; Raust, Aurélie; Roy, Isabelle; Germain, Anne; Leboyer, Marion; Bellivier, Frank

doi:10.1002/jts.20532

Cited by 142 publications

(132 citation statements)

References 58 publications

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“…In this study, we can see that the story of early traumatic experiences occurs more frequently among young people with mood disorders than in the general population of young, confirming findings of literature 23,24 . However, was not confirmed difference between the score or the occurrence of traumatic events and the different mood disorders assessed, as found in literature 11,13 .…”

Section: Discussionsupporting

confidence: 89%

Early trauma and mood disorders in youngsters

Konradt¹,

Jansen²,

Magalhães³

et al. 2013

Rev. psiquiatr. clín.

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Objective: To verify early experiences of childhood abuse and neglect among young with bipolar disorder (BD), major depression (MDD), and controls. Method: Case-control study nested to a population-based cross-sectional study. The diagnosis was performed via the structured clinical interview for DSM--IV Axis I Disorders (SCID). Traumatic events were analyzed using the Portuguese version -Questionário sobre Traumas na Infância (CTQ) -based on the Childhood Trauma Questionnaire. Results: The sample comprised 231 adolescents with 95 individuals in the control group, 82 with MDD and 54 with BD (32 of type I and 22 type II). The prevalence of trauma or violence in childhood was 42.2%; among those, 54.7% had BD, 62.2% had MDD and 18.1% were in the control group. Young people with BD or MDD obtained higher means in total CTQ and among their components when compared with those in the control group. Discussion: Reports on early traumatic experiences were more frequent among young people with mood disorders than in the general population, corroborating the literature on the subject. In this sense, the traumatic experiences during childhood seemed to contribute to the onset of the disorder.Konradt CE, et al. / Rev Psiq Clín. 2013;40(3):93-6 Keywords: Early trauma, traumatic experience, mood disorders, bipolar disorder, major depression. ResumoObjetivo: Verificar vivências precoces de abuso e negligência na infância entre jovens com transtorno bipolar (TB), transtorno depressivo maior (TDM) e controles populacionais. Método: Estudo de caso-controle aninhado a um estudo transversal de base populacional. A confirmação do diagnóstico foi realizada por meio de entrevista clínica estruturada para transtornos de eixo I do DSM-IV (SCID) e os eventos traumáticos foram verificados pelo Questionário sobre traumas na infância (CTQ). Resultados: A amostra foi composta por 231 jovens, sendo 95 indivíduos no grupo controle, 82 com TDM e 54 com TB (32 do tipo I e 22 do tipo II). A prevalência de trauma na infância foi de 42,2%, sendo 54,7% entre aqueles com TB, 62,2% entre os jovens com TDM e 18,1% entre o grupo controle. Os jovens com TB ou TDM apresentaram maiores médias no CTQ total e entre seus componentes quando comparados aos jovens do grupo controle, exceto o componente abuso sexual, em que se observou diferença estatística apenas entre o grupo controle e o grupo de jovens com transtorno bipolar. Conclusão: O relato de vivências traumáticas precoces foi mais presente entre os jovens com transtornos de humor do que na população geral, confirmando o que a literatura traz sobre o tema. Nesse sentido, as vivências de trauma na infância parecem contribuir para o aparecimento dos transtornos de humor. Konradt CE, et al. / Rev Psiq Clín. 2013;40(3):93-6 Palavras-chave: Trauma precoce, vivências traumáticas, transtornos de humor, transtorno bipolar, depressão maior.

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Section: Discussionsupporting

confidence: 89%

Early trauma and mood disorders in youngsters

Konradt¹,

Jansen²,

Magalhães³

et al. 2013

Rev. psiquiatr. clín.

View full text Add to dashboard Cite

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“…Childhood trauma and other types of adversity are now well established as significant risk factors for the development of several mental disorders, including schizophrenia and bipolar disorder (Janssen et al 2004;Kessler et al 2010;Read and Bentall 2010;Cutajar et al 2010;Etain et al 2010;Hyun et al 2000;Read et al 2005;Matheson et al 2013;Varese et al 2012;Schafer and Fisher 2011). Childhood adversity refers to a number of experiences in the early stages of life including maltreatment (encompassing physical, sexual or emotional abuse and various forms of neglect), parental loss or divorce, parental substance abuse and poverty (Rosenberg et al 2007).…”

Section: Pro-inflammatory Markers In Schizophrenia and Bipolar Disordermentioning

confidence: 99%

Stress, Schizophrenia and Bipolar Disorder

Green

Girshkin

Teroganova

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

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The role of stress in precipitating psychotic episodes in schizophrenia and bipolar disorder has long been acknowledged. However, the neurobiological mechanism/s of this association have remained elusive. Current neurodevelopmental models of psychosis implicate early dysfunction in biological systems regulating hypothalamic-pituitary-adrenal axis and immune function, with long-term effects on the development of the brain networks responsible for higher order cognitive processes and stress reactivity in later life. There is also increasing evidence of childhood trauma in psychosis, and its impact on the development of brain systems regulating stress. These findings are emerging in the context of a new era of epigenetic methods facilitating the study of environmental effects on gene expression. The evidence is thus converging: exposure to stress at critical periods in life may be an important factor in the development of the brain dysfunction that represents psychosis vulnerability, rather than merely interacting with an independent 'biological vulnerability' to manifest in psychosis.

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“…Childhood trauma, including emotional and physical abuse, is commoner in people with bipolar disorder than the general population (Etain et al, 2010), and sexual abuse commoner in those with bipolar disorder in comparison to unipolar depression (Hyun et al, 2000).…”

Section: Introductionmentioning

confidence: 99%