Preface

Colloca, Luana

doi:10.1016/s0074-7742(18)30027-8

Cited by 17 publications

(6 citation statements)

References 25 publications

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“…We will neither present nor discuss the vast body of evidence with regard to neurobiology and neurochemistry of the placebo response, but again refer to the literature, e.g., Fabrizio Benedetti´s book (33), and Luana Colloca´s reader (34, 35).…”

Section: Historical Rootsmentioning

confidence: 99%

Placebo Effects in Psychotherapy: A Framework

Enck¹,

Zipfel²

2019

Front. Psychiatry

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The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques, and ii) some of the “nonspecific effects” in drug therapy have very specific effects in psychotherapy, such as the frequency and intensity of patient–therapist interaction. In addition, different psychotherapy approaches share many such specific effects (the “dodo bird verdict”) and lack specificity with respect to therapy outcome. Here, we discuss the placebo effect in psychotherapy under four aspects: a) nonspecific factors shared with drug therapy (context factors); b) nonspecific factors shared among all psychotherapy traditions (common factors); c) specific placebo-controlled options with different psychotherapy modalities; and d) nonspecific control options for the specific placebo effect in psychotherapy. The resulting framework proposes that the exploration and enumeration of context factors, common factors, and specific factors contributes to the placebo effects in psychotherapy.

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Section: Historical Rootsmentioning

confidence: 99%

Placebo Effects in Psychotherapy: A Framework

Enck¹,

Zipfel²

2019

Front. Psychiatry

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“…To understand how placebo and nocebo science may be applied to address the current dual pain and opioid crises, we first review several elemental principles and relevant key research findings. Beginning with nomenclature, placebo and nocebo effects are psychoneurobiological responses that occur in the body as result of positive and negative expectations (Colloca, 2018a, 2018b; Wager & Atlas, 2015). Expectations result in brain events that trigger the release of endogenous neuropeptides and influence behaviors.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit

Darnall

Colloca

2018

International Review of Neurobiology

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Pain, a noxious psychosensory experience, motivates escape behavior to assure protection and survival. Psychological factors alter the experience and trajectory of pain, as well as behavior and treatment response. In the context of pain, the placebo effect (expectation for pain relief) releases endogenous opioids and facilitates analgesia from exogenously administered opioids. Nocebo hyperalgesia (expectation for persistent or worsening pain) opposes endogenous opioid analgesia and patient engagement in prescription opioid tapering. Reductions in nocebo hyperalgesia and pain catastrophizing may enhance descending modulation of pain, mediate adaptive structural brain changes and promote patient engagement in opioid tapering. Interventions that minimize nocebo and optimize placebo may adaptively shape the central nervous system toward pain relief and potentially opioid reduction. Here we provide a critical description of catastrophizing and its impact on pain, placebo and nocebo effects. We also consider the importance of minimizing nocebo and optimizing placebo effects during prescription opioid tapering, and offer a clinical toolkit of resources to accomplish these goals clinically.

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“…It is established that the practitioner's attitudes and competence may influence the magnitude of the placebo effects, which could represent around 37% to 70% of the magnitude of pain relief [56][57][58]. Moreover, the patienttherapist alliance contributes to placebo effects and health outcomes and might have contributed to the positive effect seen in these patients [56,57]. However, we did not formally evaluate expectations and the therapeutic alliance in our study.…”

Section: Orofacial Painmentioning

confidence: 90%

“…Placebo effects result from the positive psychosocial context, which can influence the patient's brain, and it is created by treatment expectations; in this way, it should be considered a powerful component in the clinical approach. It is established that the practitioner's attitudes and competence may influence the magnitude of the placebo effects, which could represent around 37% to 70% of the magnitude of pain relief [56][57][58]. Moreover, the patienttherapist alliance contributes to placebo effects and health outcomes and might have contributed to the positive effect seen in these patients [56,57].…”

Section: Orofacial Painmentioning

confidence: 99%

Effectiveness of an 8-week neck exercise training on pain, jaw function, and oral health-related quality of life in women with chronic temporomandibular disorders: a randomized controlled trial

2024

Journal of Oral &Amp; Facial Pain and Headache

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To test the effectiveness of an 8-week exercise program targeted to the neck muscles compared to manual therapy, and placebo treatments on orofacial pain intensity, jaw function, oral health-related quality of life (OHRQoL), and jaw range of motion (ROM) in women with Temporomandibular Disorders (TMD). In this randomized controlled trial, fifty-four women (between 18–45 years old) with a diagnosis of myofascial or mixed TMD according to the Research Diagnostic Criteria for TMD (RDC/TMD) were randomized into three groups: Neck motor control training (NTG), Manual Therapy Group (MTG), and Placebo Group (PG). All patients were evaluated with the Visual Analog Scale, Mandibular Function Impairment Questionnaire, Oral Health Impact Profile-14, and jaw Range of Motion (ROM) at baseline, immediately after treatment (after 8 weeks of treatment), one month, and three-month follow-up. For all outcomes, a mixed analysis of variance (ANOVA) with repeated measures was conducted with a Bonferroni post hoc test. NTG was significantly better than the PG group on pain and jaw function at the end of treatment, one- and three-month follow-up (Effect Size (ES) >0.7). For OHRQoL, NTG was significantly better than MTG and PG at the end of treatment and at three-month follow-up (ES >0.7). The results of this project are encouraging, and they could be used to guide clinical practice in this field. Exercises targeted to the neck (which require low therapeutic supervision) could be a simple and conservative way to improve pain and disability for women with TMD with neck involvement.

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Preface

Cited by 17 publications

References 25 publications

Placebo Effects in Psychotherapy: A Framework

Placebo Effects in Psychotherapy: A Framework

Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit

Effectiveness of an 8-week neck exercise training on pain, jaw function, and oral health-related quality of life in women with chronic temporomandibular disorders: a randomized controlled trial

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