Despite advances in medical practice, serious infections, including severe sepsis and septic shock, remain responsible for significant morbidity and mortality. In the United States, approximately 450,000 cases of severe sepsis and septic shock occur each year, with an estimated mortality in excess of 30%. Many other serious infections also require intensive care, however, without the development of severe sepsis and septic shock. Additionally, newly acquired nosocomial infections are known to complicate the h…
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