Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats

Kishi, Sosuke; Yamakawa, Keiko; Nakano‐Narusawa, Yuko; Kanie, Shohei; Hashimoto, Nozomi; Saoo, Kousuke; Yokohira, Masanao; Imaida, Katsumi; Matsuda, Yoko

doi:10.2131/jts.45.151

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…An overdose of acetaminophen has been reported to cause sinusoidal congestion and centrilobular necrosis [ 18 ] owing to the formation of a hepatotoxic intermediate metabolite, and it can even be fatal. In addition, acetaminophen has been reported to cause hepatocyte hypertrophy in rats [ 19 ]. Furthermore, some of the genes detected in the antecedent were indicated to be involved in liver injury.…”

Section: Discussionmentioning

confidence: 99%

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Subset-binding: A novel algorithm to detect paired itemsets from heterogeneous data including biological datasets

Natsume-Kitatani¹,

Mizuguchi²

2021

Preprint

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The integration of heterogeneous data to infer latent relationships across them and find the factors in the relationship is a challenging task. In this regard, various machine learning techniques have provided novel insights through data integration. However, concerns remain regarding their application to biological datasets because the latent consensus information across all views is often limited to partial components that do not have a significant impact on the mutual agreement across views. Advocating the idea of “subset-binding,” which focuses on finding inter-related attributes in heterogeneous data according to their co-occurrence, this study developed a novel algorithm to perform subset-binding by extending fuzzy association rule mining techniques. Our method could detect genes related to liver toxicity caused by acetaminophen in a data-driven manner; the results are consistent with those reported in the literature. This technology paves the way for a wide range of applications, including biomarker detection and patient stratification.

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Section: Discussionmentioning

confidence: 99%

“…Membership value for category "Low" = 1 -r(v)/n, (18) Membership value for category "High" = r(v)/n, (19) where r is the rank, and n is the number of observations.…”

Section: Z-score-based Conversionmentioning

confidence: 99%

Subset-binding: A novel algorithm to detect paired itemsets from heterogeneous data including biological datasets

Natsume-Kitatani¹,

Mizuguchi²

2021

Preprint

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“…The kidney index of the different treatment groups was calculated according to the following equation: (kidney weight/body weight) × 100 [ 81 , 82 ]. In addition, serum levels of creatinine [ 83 ] and blood urea nitrogen (BUN) [ 84 ] were assessed according to the previously described methods using the commercially available kits (United Diagnostics Industry, Dammam, Saudi Arabia).…”

Section: Methodsmentioning

confidence: 99%

TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity

et al. 2023

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Background: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. Toll-4 receptors (TLR4) and NLPR3 inflammasome are pattern-recognition receptors responsible for activating inflammatory responses and are assigned to play a significant role with gasdermin (GSDMD) in acute kidney injuries. N-acetylcysteine (NAC) and chlorogenic acid (CGA) have documented nephroprotective effects by suppressing oxidative and inflammatory pathways. Therefore, the current study aimed to investigate the contribution of the upregulation of TLR4/inflammasomes/gasdermin signaling to Cp-induced nephrotoxicity and their modulation by NAC or CGA. Methods: A single injection of Cp (7 mg/kg, i.p.) was given to Wistar rats. Rats received either NAC (250 mg/kg, p.o.) and/or CGA (20 mg/kg, p.o.) one week before and after the Cp injection. Results: Cp-induced acute nephrotoxicity was evident by the increased blood urea nitrogen and serum creatinine and histopathological insults. Additionally, nephrotoxicity was associated with increased lipid peroxidation, reduced antioxidants, and elevated levels of inflammatory markers (NF-κB and TNF-α) in the kidney tissues. Moreover, Cp upregulated both TLR4/NLPR3/interleukin-1beta (IL-1β) and caspase-1/GSDMD-signaling pathways, accompanied by an increased Bax/BCL-2 ratio, indicating an inflammatory-mediated apoptosis. Both NAC and/or CGA significantly corrected these changes. Conclusions: This study emphasizes that inhibition of TLR4/NLPR3/IL-1β/GSDMD might be a novel mechanism of the nephroprotective effects of NAC or CGA against Cp-induced nephrotoxicity in rats.

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Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats

Cited by 2 publications

References 23 publications

Subset-binding: A novel algorithm to detect paired itemsets from heterogeneous data including biological datasets

Subset-binding: A novel algorithm to detect paired itemsets from heterogeneous data including biological datasets

TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity

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