Preemptive versus Nonpreemptive Simultaneous Pancreas-Kidney Transplantation: A Single-Center, Long-Term, Follow-up Study

Pruijm, Menno; Fijter, Hans J. W. De; Doxiadis, Ilias I.N.; Vandenbroucke, Jan P.

doi:10.1097/01.tp.0000208574.48230.fd

Cited by 32 publications

(25 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, recipients receiving dialysis before transplantation were found to classically have a poorer 1-year survival rate compared with those undergoing preemptive SPKT (17). In another study, Pruijm et al (18) failed to demonstrate any benefit of being dialyzed before transplantation, on the pancreas, kidney, or in patient long-term survival. Paradoxically, dialysis was shown to improve platelet functional abnormalities related to uraemia and to reduce the risk of hemorrhage, the main cause of relaparotomy identified in our study (19,20).…”

Section: Discussionmentioning

confidence: 96%

Early Relaparotomy After Simultaneous Pancreas-Kidney Transplantation

Page¹,

Rimmelé²,

Ber³

et al. 2012

Transplantation

View full text Add to dashboard Cite

The early postoperative period remains a high-risk phase for relaparotomy. The selection of recipients before initiation of long-term dialysis and of donors deceased from traumatic causes may reduce the rate of these early complications after SPKT. Vascular graft thrombosis and bleeding are two major issues that arise during this critical period, suggesting the importance an adequate management of postoperative anticoagulation and hemostasis.

show abstract

Section: Discussionmentioning

confidence: 96%

Early Relaparotomy After Simultaneous Pancreas-Kidney Transplantation

Page¹,

Rimmelé²,

Ber³

et al. 2012

Transplantation

View full text Add to dashboard Cite

show abstract

“…Recipients of a preemptive SPK have better survival 8 years after transplantation when compared with those transplanted while already on dialysis [7]. Registry data also suggest that preemptive SPK is associated with improved kidney allograft survival compared to non-preemptive SPK [8].…”

Section: Timing Of Pancreas Transplantationmentioning

confidence: 99%

Current State of Combined Kidney and Pancreas Transplantation

Richter

Lerner²,

Schröppel³

2011

Blood Purif

View full text Add to dashboard Cite

Glycemic control via the use of exogenous insulin injections in diabetic patients is incomplete, resulting in multiple long-term complications, such as retinopathy, neuropathy, vasculopathy, and nephropathy. The goal of whole-pancreas and kidney transplantation is to achieve long-term insulin independence and correct uremia. The proposed benefits of pancreas and kidney transplantation are improved quality of life, prevention of recurrent diabetic nephropathy, freedom from exogenous insulin, stabilization or improvement in secondary complications, and improved mortality. No other regimen of insulin delivery or renal replacement besides pancreas and kidney transplantation can achieve this level of physiologic regulation.

show abstract

“…Additional advantages of preemptive transplant over other treatments in the young are improved growth and quality of life [14]. Patients with diabetes also gain a survival advantage with PKT [9,15]. Other benefits include cost savings through dialysis avoidance, lack of the need for a Possible limitations of the data supporting PKT include the impact of lead time bias for PKT recipients as well as the unattainable goal of considering all recipient characteristics, surgical factors and practice patterns that may impact outcome [13].…”

Section: Impact Of Preemptive Transplantationmentioning

confidence: 96%