Preeclampsia and stroke

Adamyan, L. V.; Shifman, E. M.; Arustamyan, R. R.; Lyashko, E. S.; Konysheva, O.V.

doi:10.17116/repro2016225145-150

Cited by 2 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the cause of PE has not been fully disclosed, it is generally accepted that this disease is multifactorial. It is a pregnancyspecific complication and its development is associated with the peculiarities of the gestational process itself [1,3,7].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Biomarkers of Pre-Eclampsia in Pregnant Women

Diloram A,

Gulsara Z,

Khanifa Z

et al. 2023

J. Adv. Zool.

View full text Add to dashboard Cite

Summary. According to various authors, the incidence of preeclampsia (PE) in pregnant women in our country ranges from 8 to 20% and does not tend to decrease. It has been shown that the pathogenesis of preeclampsia fits into the systemic inflammatory response syndrome with disturbances in the immune system and an imbalance in cytokine regulation. The aim of the study was to study pro-inflammatory (IL-1β, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in women with preeclampsia of varying severity. Material and methods. We examined 76 pregnant women with PE aged from 24 to 36 years at a gestation period of 28–38 weeks. Of these, 42 developed PE (main group), and 34 women had no symptoms of PE (comparison group). 28 women with a physiological pregnancy formed the control group. The levels of pro- and anti-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-4 and IL-10) in blood serum were studied by ELISA. Results. In pregnant women with PE upon admission to the hospital, the blood serum levels of IL-1β increased by 1.3 times (p < 0.05), IL-8 by 7 times (p < 0.001) and a decrease in the level of IL-4 by 2 times (p < 0.001). And in pregnant women without signs of PE, these changes in cytokine synthesis were less pronounced (p < 0.01). Conclusion. Maintaining a dynamic balance in the cytokine system plays an important role for the normal development of pregnancy. Th2-type cytokines promote normal trophoblast differentiation and its full invasion and, therefore, mediate the prolongation of physiological pregnancy. Switching to the synthesis of Th1-type cytokines and their enhanced production leads to disruption of trophoblast differentiation and invasion with the development of pregnancy pathology.

show abstract

Section: Introductionmentioning

confidence: 99%

Prognostic Biomarkers of Pre-Eclampsia in Pregnant Women

Diloram A,

Gulsara Z,

Khanifa Z

et al. 2023

J. Adv. Zool.

View full text Add to dashboard Cite

show abstract

The role of arterial hypertension in the development of cerebrovascular diseases in pregnancy

Чухловина

Medvedev

2018

Arter. gipertenz.

View full text Add to dashboard Cite

Nowadays, the risk factors, improvement of diagnosis and treatment of cardiovascular diseases are of particular interest. Arterial hypertension (HTN) is known to contribute to cardiovascular disease and to be a risk factor for cerebrovascular diseases. HTN during pregnancy and in the postpartum period draws particular attention. Throughout the world, hypertension during pregnancy remains the leading cause of maternal and child morbidity and mortality. To our knowledge, only a few works studied neurological disorders associated with HTN in pregnant women. In this connection, the purpose of our review was to analyze the role of HTN in the development of cerebrovascular diseases in pregnancy. Pregnant women with HTN show 5,2-fold higher frequency of strokes than normotensive women. The risk of stroke increases from the third trimester of pregnancy to six weeks of the postpartum period. The pregnant women with HTN develop changes in the coagulation system leading to the formation of arterial and venous thromboses in the cerebrovascular circulation. The presence of preeclampsia (PE) is associated with the 7–9-fold increase in the risk of stroke. Endothelial dysfunction is one of the leading links in the pathogenesis of PE. The PE is associated with an increase in anti-angiogenic factors and a decrease in angiogenic factors. Thus, the measures preventing the development of cerebrovascular diseases in pregnant women with HTN, include identification of prehypertension in women of childbearing age, the improvement of HTB management strategies, and an interdisciplinary approach to the diagnostic and treatment process involving the obstetrician, the therapist, the cardiologist and the neurologist.

show abstract

Preeclampsia and stroke

Cited by 2 publications

References 10 publications

Prognostic Biomarkers of Pre-Eclampsia in Pregnant Women

Prognostic Biomarkers of Pre-Eclampsia in Pregnant Women

The role of arterial hypertension in the development of cerebrovascular diseases in pregnancy

Contact Info

Product

Resources

About