2018
DOI: 10.1016/j.bjid.2018.07.005
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Predominance of Leishmania major and rare occurrence of Leishmania tropica with haplotype variability at the center of Iran

Abstract: L. major was considered the causative agent of leishmaniasis in the region, but the identification of a non-native L. tropica revealed the importance of further isolation of Leishmania parasites following molecular analyses and confirmation, and also revealed the importance of further isolation of Leishmania parasites from patients of the field areas who do not have easily access to health care centers for specialized treatment strategies.

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Cited by 10 publications
(9 citation statements)
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“…Similar to other rodent reservoir host studies conducted worldwide, our phylogenetic study revealed a low number of available Leishmania ITS1 sequences, regardless of the origin of the host in Tunisia (≤50 sequences ( Supplementary Tables S2 and S3 )). Furthermore, we confirmed that ITS1 sequences could segregate between Leishmania spp., even for small samples [ 9 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…Similar to other rodent reservoir host studies conducted worldwide, our phylogenetic study revealed a low number of available Leishmania ITS1 sequences, regardless of the origin of the host in Tunisia (≤50 sequences ( Supplementary Tables S2 and S3 )). Furthermore, we confirmed that ITS1 sequences could segregate between Leishmania spp., even for small samples [ 9 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, designing of primers for distinguishing causative agents of leishmaniasis is necessary to find an application with high sensitivity, efficiency, and accuracy 2 , 5 , 19 . In healthcare and research centers of endemic foci of the disease, which have a high number of patients and patrons, accuracy and speed are of great importance 7 , 11 , 24 .…”
Section: Discussionmentioning
confidence: 99%
“…The vertebrate animals were bitten by female sand flies and thus developed ZCL. Humans were involved in Leishmania parasites and they were involved ACL by humans oppositely 5 , 6 .…”
Section: Introductionmentioning
confidence: 99%
“…Leishmania parasites make intracellular protozoa infect reticuloendothelial macrophages in the vertebrate hosts as amastigote form while as a motile flagellated promastigote invertebrate sand fly vector (1,2). Dry-type CL, induced by L. tropica, is reported just in eight different cities, while wet-type CL is observed in many regions of the country with a 95% prevalence rate (3,4). A standard CL treatment is antimony-containing agents such as meglumine antimonite or glucantime (Glu) and sodium stibogluconate (Pentostam) with intralesional or systematic administration; however, some studies have reported resistance to these agents (5)(6)(7)(8).…”
Section: Introductionmentioning
confidence: 99%