Predictors of sudden cardiac death in hypertrophic cardiomyopathy

Characterization of Left Ventricular Diastolic Function by Tissue Doppler Imaging and Clinical Status in Children With Hypertrophic Cardiomyopathy

“…[1][2][3][4][5][6][7]19,21,22 The importance of septal thickness as a predictor of SCD remains contentious. Spirito et al 5 reported no incidence of SCD in 400 patients with septal thickness Ͻ15 mm compared with a 2% annual risk in patients with a septal thickness Ͼ30 mm.…”

“…19,20 Mitral inflow Doppler was measured in standard fashion to determine peak E-and A-wave velocities, deceleration time of the transmitral E wave, and isovolumic contraction and relaxation times. 13 Pulmonary venous inflow Doppler patterns were analyzed to determine the peak velocities of the systolic, diastolic, and atrial reversal waves.…”

Usefulness of real-time three-dimensional echocardiography for evaluation of myectomy in patients with hypertrophic cardiomyopathy

“…[1][2][3] Elimination or reduction of LVOT obstruction is associated with improved functional status and less symptoms. Currently, the primary options to achieve this aim include myectomy 4 -6 and septal alcohol ablation.…”

Diagnosis and Management of Hypertrophic Cardiomyopathy

“…Despite the significant association between LVTO and SCD (86,93,94,95), the question about the prognostic significance of the provocable LVOTO and the LVOT gradient after treatment remains unresolved. A recent retrospective study has suggested a lower rate of implantable defibrillator insertion, adverse events, medical interventions and septal ablations in patients who show a paradoxical response to exercise defined as a reduction in the LVOT gradient during exercise, therefore reinforcing the importance of echocardiography in risk stratification (96).…”