Predictors of Residue and Airway Invasion in Parkinson’s Disease

Curtis, James A.; Molfenter, Sonja M.; Troche, Michelle S.

doi:10.1007/s00455-019-10014-z

Cited by 46 publications

(34 citation statements)

References 51 publications

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“…Our OR (1.11) for LVrt indicated a small increase in the odds of an abnormal penetration or aspiration event (11%) with slower LVrt times. It is possible that the low OR is due to sample size as our findings agree with recent work by Curtis et al [12]. Predictive models have also shown that other kinematic factors including hyolaryngeal movement are useful predictors for decreased airway safety in PWPD [37] and warrant further investigation.…”

Section: Airway Invasion and Laryngeal Kinematicssupporting

confidence: 90%

“…In order to conduct this analysis, PAS scores were coded to reflect either a "normal" and safe swallow (PAS score of 1 or 2), or "abnormal" (PAS score > 3). This method has been suggested as one of several appropriate approaches with a logistic regression [26] and used in recent work [12] to quantify the PAS. Receiver operating characteristics (ROC) analysis was then performed to produce an area under the curve (AUC) for sensitivity and specificity of screening methods (SDQ and 3 oz WSST) for predicting those who are at risk of dysphagia.…”

Section: Methodsmentioning

confidence: 99%

“…While laryngeal kinematics during swallowing, such as laryngeal vestibule closure reaction and duration times, are likely associated with dysphagia (specifically airway invasion) in PWPD, they have not been investigated until recently. Current evidence has shown that the timing of airway closure was the strongest predictor of airway invasion in non-advanced PD [12]. However, further knowledge of laryngeal function during swallowing in PWPD is needed to more fully inform our understanding of laryngeal impairment as the disease progresses and to inform treatment planning for rehabilitation of swallowing function.…”

Section: Introductionmentioning

confidence: 99%

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Predicting Airway Invasion Using Screening Tools and Laryngeal Kinematics in People with Parkinson’s Disease: A Pilot Study

Dumican

2020

JPD

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Background: Dysphagia in Parkinson's disease (PD) is a common manifestation, particularly in advanced disease stages. However, the pathophysiology and time course of dysphagia progression remains unclear in non-advanced disease stages (e.g., Hoehn & Yahr stages I-III). Conflicting reports from investigations of the perception of dysphagia in people with PD further complicates our understanding of dysphagia in this population. Objective: The objectives of this research were to evaluate the ability of screening tools to detect swallowing impairments and how laryngeal kinematics predict the occurrence of abnormal swallowing events. Methods: 14 individuals with non-advanced PD, no previous history of dysphagia diagnosis, and self-reported difficulty swallowing participated. The Swallow Disturbance Questionnaire (SDQ) and 3-oz water swallow test (WSST) were administered, along with a videoflouroscopic swallow study (VFSS). Laryngeal kinematics were represented by laryngeal vestibule closure reaction time (LVrt) and laryngeal vestibule closure duration (LVCd). The Penetration-Aspiration Scale (PAS) was used to quantify airway invasion. Results: A logistic regression indicated a significant model of predicting airway invasion from our predictors (p = 0.003). LVrt and SDQ (p < 0.05) provided the largest impact (OR = 1.11; 1.17). The WSST showed no significance in predicting swallow impairment (p > 0.05). Conclusion: Decreased airway safety related to laryngeal kinematic function in PD may be manifesting at non-advanced disease stages to varied degrees. Our results support expectations of dysphagia manifestation in PD although screening practices may not adequately identify impairment. Future research should target specific laryngeal characteristics within this population to better understand the physiological cause of swallowing impairment and developof targeted interventions.

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Section: Airway Invasion and Laryngeal Kinematicssupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predicting Airway Invasion Using Screening Tools and Laryngeal Kinematics in People with Parkinson’s Disease: A Pilot Study

Dumican

2020

JPD

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“…Parkinson's disease itself is not considered fatal [28]; however, due to a lack of any disease-modifying therapy, as disease progresses, swallowing turns to be compromised causing aspiration pneumonia that can life threatening [29]. Moreover, since the quality of life of PD patients is significantly diminished, there is an ongoing search for compounds capable of protecting neurons from a broad range of insults.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

Kujawska

Jourdes

Kurpik

et al. 2019

IJMS

109

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Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate’s health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites—urolithins. In this study, we examined the capability of pomegranate juice for protection against PD in a rat model of parkinsonism induced by rotenone. To evaluate its efficiency, assessment of postural instability, visualization of neurodegeneration, determination of oxidative damage to lipids and α-synuclein level, as well as markers of antioxidant defense status, inflammation, and apoptosis, were performed in the midbrain. We also check the presence of plausible active pomegranate ETs-derived metabolite, urolithin A, in the plasma and brain. Our results indicated that pomegranate juice treatment provided neuroprotection as evidenced by the postural stability improvement, enhancement of neuronal survival, its protection against oxidative damage and α-synuclein aggregation, the increase in mitochondrial aldehyde dehydrogenase activity, and maintenance of antiapoptotic Bcl-xL protein at the control level. In addition, we have provided evidence for the distribution of urolithin A to the brain.

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“…Deterioration in immune system functions, known as immunosenescence, is also well documented in the older adult population and is acerbated by poor nutritional status [10,11]. Sarcopenia and immunosenescence are presented as predisposing factors to aspiration pneumonia in frail older adult populations [12][13][14][15][16] further complicating the evaluation of the causes of recurrent aspiration pneumonia in this population. Providing nutritious and safe texture modified foods are key elements in mitigating dysphagia impacts ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Is IDDSI an Evidence-Based Framework? A Relevant Question for the Frail Older Population

Côté

Giroux²,

Villeneuve-Rhéaume

et al. 2020

Geriatrics

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To delay impacts of aging, optimal nutritional status is essential. Several factors can reduce food intake, such as isolation, income, and cognitive/physical decline. Additionally, chewing and swallowing difficulties, or dysphagia, often disrupt the ability to consume life-long favorite dishes. Food and liquids could require modification of texture or consistency to ensure a comfortable or safe swallow. The food industry, foodservices facilities, and caregivers need quality control benchmarks to provide adequate nourishment and meet these new feeding challenges. The International Dysphagia Diet Standardisation Initiative (IDDSI) is proposing the IDDSI framework and testing methods to describe food used in nutritional care plans to circumvent dysphagia and improve communication among caregivers. This systematic review assesses the validity and reliability of the IDDSI testing methods using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN). Two publications presented content validity whereas 19 publications looked at construct validity or reliability for the IDDSI testing methods. One study was conducted in older adults presenting dysphagia. This review concludes that there is insufficient evidence to recommend the IDDSI testing methods. Further research, conducted with robust methodological design and reporting, is needed to develop and assess nutritious adapted food for frail older populations.

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Predictors of Residue and Airway Invasion in Parkinson’s Disease

Cited by 46 publications

References 51 publications

Predicting Airway Invasion Using Screening Tools and Laryngeal Kinematics in People with Parkinson’s Disease: A Pilot Study

Predicting Airway Invasion Using Screening Tools and Laryngeal Kinematics in People with Parkinson’s Disease: A Pilot Study

Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

Is IDDSI an Evidence-Based Framework? A Relevant Question for the Frail Older Population

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