Predictors of Noncompliance with Warfarin Therapy in an Outpatient Anticoagulation Clinic

Orensky, Ian A.; Holdford, David A.

doi:10.1592/phco.2005.25.12.1801

Cited by 75 publications

(60 citation statements)

References 11 publications

(19 reference statements)

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“…The available data derive from the experiences on patients using VKAs. Various studies have shown that adherence to therapy with VKAs were affected by ethnical origin, economic status, educational level, employment status, missing doses, lack of knowledge on drug usage, use of additional drugs, drug and alcohol dependence, and emotional factors [23][24][25][26]. IN-RANGE study investigated factors affecting adherence to therapy with VKAs for the duration of 32 months.…”

Section: Causes Of Non-adherencementioning

confidence: 99%

Evaluation of drug adherence in patients with non-valvular atrial fibrillation according to geographic regions of Turkey: an analysis from NOAC-TR study

Emren¹,

Zoghi²,

Açıksarı³

et al. 2017

Med-Science

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Drug adherence to novel oral anticoagulants (NOAC) varied by countries and popuplations. As a result of NOAC-TR study, in Turkey, drug adhrence to NOACs is poor comparing to other real world studies. However it is not known whether there is a difference between geographic regions of Turkey in terms of NOAC adherence. In this study we aim to investigate the NOAC adherence in patients with non-valvular atrial fibrillation according to the geographic regions in Turkey Method: This cros-sectional study was designed as a subgroup study of NOAC-TR (Drug Adherence in patients with non valvular atrial fibrillation taking non-vitamin K antagonist oral anticoagulants in Turkey). A total of 2802 patients (59% female) taking NOAC (Dabigatran, apixaban, rivaroxaban) due to NVAF at least 3 months, were included. Morisky-8 item drug adherence scale was used. Patients were divided in 3 groups (high, moderate and low adherent) based on drug adherence Results: Of the patients 24% were adherent, 26% were moderate adhererent and 50% were low adherent to NOAC treatment. Drug adhrence was different between geographic regions (p<0,001). In post-hoc analysis low adherent rate was highest in Blacksea region (72% low adherent, 21% moderate adherent, 7% low adherent). Adherence rate was highest in Aegean (36% adherent, 26% moderate adherent 38%) and Marmara region (38% adherent, 28% moderate adherent 34% low adherent). Conclusion: NOAC adherence was different between geographic regions in Turkey.

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Section: Causes Of Non-adherencementioning

confidence: 99%

Evaluation of drug adherence in patients with non-valvular atrial fibrillation according to geographic regions of Turkey: an analysis from NOAC-TR study

Emren¹,

Zoghi²,

Açıksarı³

et al. 2017

Med-Science

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“…Other contributing factors were current living conditions, marital status and employment status (10,11).…”

Section: Patient's Compliancementioning

confidence: 99%

Factors influencing vitamin K antagonists therapy / Factori care influențează terapia cu antagoniști ai vitaminei K

Brudașcă¹

2015

Romanian Review of Laboratory Medicine

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“…For example, one study showed that noncompliance (as measured by a pill count) of <80% was significantly linked with severe thromboembolic events (transient ischemic attack, stroke). In another study, 28% of INR values above 6 (therapeutic range 2-3) were due to poor compliance, thus predisposing patients to an increased risk of hemorrhagic events [7].…”

Section: Introductionmentioning

confidence: 97%

Effects of Pharmacist Counseling on Compliance and Inr Score on Outpatients Receiving Warfarin at Dr. Hasan Sadikin Bandung Hospital West Java, Indonesia

Putriana

Lestari

Barliana

et al. 2017

Asian J Pharm Clin Res

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Objective: Warfarin is a derivate of coumarin, which is usually prescribed as an oral anticoagulant for treatment and prevention of thromboembolic disorders. The aim of present research is to analyze the influence of pharmacist counseling on compliance and international normalized ratio (INR) score recovery on warfarin management. Methods:Design in this research used mixed method, combination of qualitative and quantitative method. Qualitative data were used for completing quantitative data. Qualitative method used a content analysis with interview. Quantitative method used a quasi-experimental method with control groups, pre-test, and post-test design. Data were analyzed by Wilcoxon test and Mann-Whitney test at significance level p≤0.05 and multivariate analysis covariate.Results: Data were collected from 80 patients with rheumatic heart disease (42.5%), atrial fibrillation (17.5%), deep vein thrombosis (10%), rheumatic mitral valve disease (10%), prosthetic heart (7.5%), other (22.5%). The numbers of patients whose INR was in the therapeutic range for each indication was not statistically different between before and after receiving counseling (p>0.05), Patients' behavior compliance of warfarin therapy had increased after receiving the counseling service (p<0.05). The result of presents research is pharmacist counseling affected behavior compliance before and after counseling (p<0.05) but not for INR (p>0.05). Conclusion:Pharmacist counseling can improve behavior compliance but not improve INR target. The effect of warfarin to every individual not only affected by behavior compliance but also several factors could influence effect of warfarin is clinical factors, non-clinical factors, and genetic factors. Clinical factors that were influenced were age, gender, pharmacokinetic and pharmacodynamic variability in patients.

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Predictors of Noncompliance with Warfarin Therapy in an Outpatient Anticoagulation Clinic

Cited by 75 publications

References 11 publications

Evaluation of drug adherence in patients with non-valvular atrial fibrillation according to geographic regions of Turkey: an analysis from NOAC-TR study

Evaluation of drug adherence in patients with non-valvular atrial fibrillation according to geographic regions of Turkey: an analysis from NOAC-TR study

Factors influencing vitamin K antagonists therapy / Factori care influențează terapia cu antagoniști ai vitaminei K

Effects of Pharmacist Counseling on Compliance and Inr Score on Outpatients Receiving Warfarin at Dr. Hasan Sadikin Bandung Hospital West Java, Indonesia

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