Predictors of Mortality in Patients of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Prospective Observational Study

Kumar, Hemant; Choubey, Satyadeo

doi:10.4103/ijrc.ijrc_21_17

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…The present study results showed that within the AECOPD inhospital patients, the mortality was 18.4%, significantly higher than the reported validation studies with a 7.7% prediction value or a value between 7.58 and 17% in various studies [12][13][14][15] . The justification for this high mortality rate prediction can be the geographical region wherein the country faces a high poverty ratio and is unaware of the associated risk factors and symptoms of AECOPD and other healthcare services.…”

Section: Discussioncontrasting

confidence: 67%

Comparison of NEWS2 and CURB65 Score in Predicting Mortality of Hospitalized patients with AECOPD

Kumari,

Kumar,

Akhter

et al. 2024

PJMHS

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Aim: To determine the diagnostic accuracy of the NEWS2 and CURB-65 scores in predicting in-hospital mortality in patients with acute exacerbations of COPD, mortality during hospital stays is considered the gold standard. Study Design: Cross-sectional study-design. Place and duration of study: Department of Chest Medicine, JPMC, Karachi, from September 25, 2020, to January 25, 2021. Two hundred and twelve patients of both genders were included who were admitted because of acute COPD exacerbations. The National Early Warning Score 2 (NEWS2) and CURB-65 Score in the estimation and evaluation of hospital-related mortality were noted. Results: NEWS2 predicted 156(73.6%), CURB-65 predicted 72(34%) as high-risk patients, and in-hospital mortality was 39(18.4%). NEWS2 had shown sensitivity of 100%, specificity of 32.4%, diagnostic accuracy of 45%, PPV of 25.1%, and NPV of 100% as a prediction value of in-hospital mortality. CURB-65 had shown sensitivity of 76.9%, specificity of 75.7%, and diagnostic accuracy of 76%, PPV of 41.7%, and NPV of 93.6% as a prediction value of in-hospital mortality. Implication: It is recommended that individual analyses of these associated factors be performed in future studies for the formulation of novel, efficient scores that may be better predictors of mortality in AECOPD patients. Conclusion: Both of the scoring systems can be used for the purpose of AECOPD patients risk stratification as per clinicians’ preference and as the basic tools of assessment in a resource-poor country. Keywords: Acute exacerbation of COPD, NEWS2, CURB-65, In-hospital mortality

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Section: Discussioncontrasting

confidence: 67%

Comparison of NEWS2 and CURB65 Score in Predicting Mortality of Hospitalized patients with AECOPD

Kumari,

Kumar,

Akhter

et al. 2024

PJMHS

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“…Elevated PaCO2 is a sign of acidosis, which in chronic patients is compensated by increased bicarbonate levels, keeping the pH in the normal range. 11 Another predictor of severe morbidity and mortality was FEV1 volume which was 1.05 ± 0.51 L in our study. The average FEV1/FVC ratio was 46.3%.…”

Section: Discussionsupporting

confidence: 47%

“…In case of ventilated patients, this rate may go up higher to 40%. [11][12][13] In India, a mortality rate of 12% has been reported among the persons who were hospitalized. 14 During COPD, there is an increased decline in the forced expiratory volume in 1 second by the patient with age leading to airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

Predictors of morbidity and mortality in acute exacerbation in chronic obstructive pulmonary disease: A study in a tertiary care unit

Sujatha¹,

Pannathota²

2020

IJIRM

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Introduction: Chronic obstructive pulmonary disease is one of the leading causes of morbidity and mortality worldwide. Many people with COPD suffer from Acute exacerbations of COPD which affects their health and poor prognosis, leading to increased costs of hospitalization and quality of life. Materials and Methods: 69 patients were initially screened by Gold criteria to establish COPD Exacerbations were measured as per Anthonisen's criteria and the patient was admitted into the ICU. Hematological and biochemical investigations were done and exacerbation were graded. Results: The mean age of the patients was 67.2 ± 9.8 years. Out of the 69 patients, 6 of them died during their stay at the hospital. 58% of them were smokers having more than 2 pack of cigarettes per day. The most common comorbity present among these patients was Diabetes in 44.9% of them followed by tuberculosis in 34.8% patients. Conclusion: Some of the risk factors for acute exacerbations in COPD are age, diabetes, FEV1 volume, PaCO2 levels, smoking. Therefore, to reduce the morbidity and mortality of the patient's an early detection is essential so that treatment con be started. Moreover, since future exacerbations normally occur in such patients, they need to be monitored before their symptoms become more prominent.

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“…The major outcome our study has shown is 34 (29.8%) in-hospital mortalities which was substantially higher than the mortalities reported in the validation studies of predicting inhospital mortalities in acute ECOPD, i.e., 7.7% by Echevarria et al, 7.58% by Yousif and El Wahsh, 12.5% by Nafae et al, 17% by Kumar and Choubey, all of which had comparable sample sizes except the study by Echevarria et al (sample of >800 patients) [6,8,13,14]. The reason for higher mortality rate in our study may be poverty, ignorance of the risk factors and symptoms of acute ECOPD and lack of awareness about emergency and routine healthcare services that an individual can have access to before their situation becomes life-threatening.…”

Section: Discussionmentioning

confidence: 65%

DECAF versus CURB-65 to Foresee Mortality among Patients Presenting with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Ahmed

Jawad

Jafri

et al. 2020

Cureus

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Predictors of Mortality in Patients of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Prospective Observational Study

Cited by 5 publications

References 16 publications

Comparison of NEWS2 and CURB65 Score in Predicting Mortality of Hospitalized patients with AECOPD

Comparison of NEWS2 and CURB65 Score in Predicting Mortality of Hospitalized patients with AECOPD

Predictors of morbidity and mortality in acute exacerbation in chronic obstructive pulmonary disease: A study in a tertiary care unit

DECAF versus CURB-65 to Foresee Mortality among Patients Presenting with an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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