Predictors of Long-Term Survival in Patients With Malignant Ventricular Arrhythmias

Gomes, J. Anthony; Mehta, Davendra; Ip, John; Winters, Stephen L.; Camuñas, Jorge; Ergin, Arisan; Newhouse, Teri Takle; Pe, Elena

doi:10.1016/s0002-9149(97)00046-5

Cited by 29 publications

(10 citation statements)

References 24 publications

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“…During the healing phase, episodes of nonsustained VT have no prognostic significance, while episodes of sustained VT do. However, during the chronic or remodeling phase, both sustained and nonsustained episodes of VT and inducibility of VT by programmed ventricular stimulation are associated with an increased incidence of life-threatening arrhythmias and decreased survival (14,15,33). Ventricular healing following MI in the mouse has been shown to occur over the first 2 weeks after MI (23).…”

Section: Figurementioning

confidence: 99%

“…Furthermore, 2 weeks following MI, SREBP-1 KO mice demonstrated a marked incidence of inducible ventricular arrhythmias compared with WT mice. Inducibility of ventricular tachycardia (VT) following the healing phase of an MI has been shown to have prognostic significance for the development of life-threatening arrhythmias and sudden death (14,15). These findings suggest a unique relationship between lipid regulation of parasympathetic responsiveness of the heart and the development of ventricular arrhythmia.…”

Section: Introductionmentioning

confidence: 99%

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Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

et al. 2008

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Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation of the G protein-coupled inward rectifying K + channel GIRK1/4 and results in an acetylcholine-sensitive K + current, I KACh . We describe a unique relationship between lipid homeostasis, the lipid-sensitive transcription factor SREBP-1, regulation of the cardiac parasympathetic response, and the development of ventricular arrhythmia. In embryonic chick atrial myocytes, lipid lowering by culture in lipoprotein-depleted serum increased SREBP-1 levels, GIRK1 expression, and I KACh activation. Regulation of the GIRK1 promoter by SREBP-1 and lipid lowering was dependent on interaction with 2 tandem sterol response elements and an upstream E-box motif. Expression of dominant negative SREBP-1 (DN-SREBP-1) reversed the effect of lipid lowering on I KACh and GIRK1. In SREBP-1 knockout mice, both the response of the heart to parasympathetic stimulation and the expression of GIRK1 were reduced compared with WT. I KACh , attenuated in atrial myocytes from SREBP-1 knockout mice, was stimulated by SREBP-1 expression. Following myocardial infarction, SREBP-1 knockout mice were twice as likely as WT mice to develop ventricular tachycardia in response to programmed ventricular stimulation. These results demonstrate a relationship between lipid metabolism and parasympathetic response that may play a role in arrhythmogenesis.

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

et al. 2008

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“…More than 80,000 ICDs were implanted in 2000 [3]. Several studies provided evidence that ICDs reduce mortality from SCD more than antiarrhythmic drug therapy [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…No studies evaluate the relationship between QOL and mortality in patients who received ICDs. Among ICD recipients, left ventricular ejection fraction (EF) [4,[16][17][18][19], New York Heart Association (NYHA) classification [5,16,20,21], ICD shocks [20,22], a history of sustained ventricular tachycardia (VT) [23], age [22], and gender [20] predicted long-term mortality.…”

Section: Introductionmentioning

confidence: 99%

“…The first year of ICD treatment probably is the critical period for patients. Most studies of mortality in ICD recipients investigated predictors of long-term mortality [4,5,[16][17][18][19][20][21][22][23], but not of mortality in the first year. Identification of predictors of mortality in the first year after ICD implantation may assist in developing health care programs for patients who receive ICDs.…”

Section: Introductionmentioning

confidence: 99%

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