Predictors of irritability symptoms in mildly depressed perimenopausal women

Wit, Anouk E. de; Giltay, Erik J.; Boer, Marrit K. de; Nathan, Margo; Wiley, Aleta; Crawford, Sybil L.; Joffe, Hadine

doi:10.1016/j.psyneuen.2021.105128

Cited by 17 publications

(13 citation statements)

References 37 publications

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“…Through the generalized estimation equation, we found that some sociodemographic variables were associated with depressive symptoms. The older the age, the more severe the depressive symptoms in perimenopausal women, which is consistent with the study findings of H-L Lin et al [ 33 ] and Anouk E. de Wit et al [ 34 ]. Compared with the women whose marital status was married, those with single and widowed marital status reported more severe depressive symptoms, which may be related to loneliness in single and widowed status [ 35 ].…”

Section: Discussionsupporting

confidence: 91%

Depressive symptoms and physical activity among community-dwelling perimenopausal women: a prospective longitudinal study

et al. 2023

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Background Women in perimenopause are vulnerable to depressive symptoms, and physical activity was reported to be a potential protective factor. The trajectories of physical activity and depressive symptoms over time and their longitudinal relationships in Chinese perimenopausal women have not been explored yet, leaving a research gap hindering us from better understanding and managing perimenopause depressive symptoms. Methods A multi-center prospective longitudinal study was conducted in four cities in Sichuan Province, China. Depressive symptoms and physical activity in perimenopausal women were collected in March 2019, June 2019, September 2019, and December 2019, respectively. Multivariable linear regression by generalized estimation equation was used to identify the relevant factors associated with depressive symptoms and physical activity. A four-wave autoregressive and cross-lagged panel model was performed to explore their longitudinal relationships. Results A total of 1875 women who completed the four-wave data collection were included in the data analysis. Depressive symptoms exacerbated over time and were associated with women’s age, monthly income, marital status, chronic disease, and negative life events. Physical activity decreased over time and was associated with educational background and monthly income. According to the cross-lagged panel model, perimenopausal women with more severe depressive symptoms tended to be less physically active, and similarly, perimenopausal women with less physical activity were more prone to report more severe depressive symptoms. Conclusion The cross-lagged panel model disclosed longitudinal bidirectional relationships between depressive symptoms and physical activity in perimenopausal women. Appropriate physical activity should be recommended for perimenopausal women to improve their mental well-being. Tailored physical activity duration and maintenance measures should be proposed based on different sociodemographic statuses.

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Section: Discussionsupporting

confidence: 91%

Depressive symptoms and physical activity among community-dwelling perimenopausal women: a prospective longitudinal study

et al. 2023

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“…Some studies also indicate a significantly increased risk of depression after ovariectomy [ 37 ]. An increased risk of depression was also observed in perimenopause with naturally occurring menopause [ 29 ], which may be associated with increased variability in estradiol levels [ 38 , 39 ]. This relationship is indicated by direct estradiol studies showing that pharmacological manipulation of estrogen levels in women resulted in depressive symptoms compared to the placebo group [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders

Turek

Gąsior

2023

Pharmacol. Rep

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Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with women's well-being. This narrative review discusses the available knowledge on the role of estrogen in modulating brain function and the correlation between changes in estrogen levels and the development of depression. Equally discussed are the possible mechanisms underlying these effects, including the role of estrogen in modulating brain-derived neurotrophic factor activity, serotonin neurotransmission, as well as the induction of inflammatory response and changes in metabolic activity, are discussed.

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“…One possible explanation is its interaction with GABA receptors [ 75 ]. Likewise, in premenopausal depressive disorder, progesterone levels remain constant [ 76 ] but E2 stands out when its levels are higher, assuming a direct risk of the intensification of depressive symptoms at this stage [ 77 ].…”

Section: Major Depressive Disorder In Womenmentioning

confidence: 99%

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

et al. 2022

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Major depressive disorder (MDD) is an incapacitating condition characterized by loss of interest, anhedonia and low mood, which affects almost 4% of people worldwide. With rising prevalence, it is considered a public health issue that affects economic productivity and heavily increases health costs alone or as a comorbidity for other pandemic non-communicable diseases (such as obesity, cardiovascular disease, diabetes, inflammatory bowel diseases, etc.). What is even more noteworthy is the double number of women suffering from MDD compared to men. In fact, this sex-related ratio has been contemplated since men and women have different sexual hormone oscillations, where women meet significant changes depending on the age range and moment of life (menstruation, premenstruation, pregnancy, postpartum, menopause…), which seem to be associated with susceptibility to depressive symptoms. For instance, a decreased estrogen level promotes decreased activation of serotonin transporters. Nevertheless, sexual hormones are not the only triggers that alter neurotransmission of monoamines and other neuropeptides. Actually, different dietary habits and/or nutritional requirements for specific moments of life severely affect MDD pathophysiology in women. In this context, the present review aims to descriptively collect information regarding the role of malnutrition in MDD onset and course, focusing on female patient and especially macro- and micronutrient deficiencies (amino acids, ω3 polyunsaturated fatty acids (ω3 PUFAs), folate, vitamin B12, vitamin D, minerals…), besides providing evidence for future nutritional intervention programs with a sex-gender perspective that hopefully improves mental health and quality of life in women.

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Predictors of irritability symptoms in mildly depressed perimenopausal women

Cited by 17 publications

References 37 publications

Depressive symptoms and physical activity among community-dwelling perimenopausal women: a prospective longitudinal study

Depressive symptoms and physical activity among community-dwelling perimenopausal women: a prospective longitudinal study

Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

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