Predictors of high‐risk and low‐risk oral <scp>HPV</scp> infection in the <scp>U</scp>nited <scp>S</scp>tates

Orosco, Ryan K.; Kedarisetty, Suraj; Hecht, Avram S.; Chang, David C.; Coffey, Charles S.; Weissbrod, Philip A.

doi:10.1002/lary.25822

Cited by 15 publications

(16 citation statements)

References 21 publications

(50 reference statements)

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“…Similarly, the 2009–2010 NHANES documented that the prevalence of oral HPV infection in the US was 6.9%, and no significant differences were found by gender or race/ethnicity [5] . Nonetheless, more recent US data showed a prevalence of infection of 8.1%, and lower odds of infection with low-risk HPV types among non-Hispanic Whites compared to Hispanics [6] . Lower odds of both low-risk and high-risk HPV infections were also seen for women in the NHANES studies.…”

Section: Discussionmentioning

confidence: 94%

“…While the prevalence of HPV in oropharyngeal cancers has increased, with estimates of 72% in North America, Europe and other populations [4] , prevalence of oral HPV infection in cancer-free individuals, risk factors, natural history, and transmission mechanisms remain largely unexplored. In the US, prevalence estimates of oral HPV infection were 6.9% in 2009–2010 5 and 8.1% during 2009–2012 [6] . Oral sex, male gender, older age, open-mouthed kissing, increasing number of sexual partners, HIV infection, tobacco, and marijuana and heavy alcohol use have been associated with oral HPV infection [5] , [7] , [8] .…”

Section: Introductionmentioning

confidence: 99%

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Periodontitis and oral human papillomavirus infection among Hispanic adults

Ortiz

González

Vivaldi-Oliver

et al. 2018

Papillomavirus Research

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IntroductionResearch on the association between periodontitis and oral human papilloma virus (HPV) infection is inconsistent. The cross-sectional association of severe periodontitis with oral HPV infection was investigated in a sample of Hispanic adults.MethodsData from the 2014–2016 San Juan Overweight Adults Longitudinal Study (n = 740) was analyzed. Periodontitis assessment and self-collection of oral HPV samples followed the National Health and Nutrition Examination Survey methodology. Periodontitis was defined using the Centers of Disease Control and Prevention/American Academy of Periodontology definition. HPV typing was performed using polymerase chain reaction. Multivariate logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).Results5.7% of participants had oral HPV infection and 20.3% had severe periodontitis. Adults with severe periodontitis had higher odds of oral HPV infection than those with none/mild disease (OR=2.9, 95% CI: 1.0–8.4, p < 0.05) in multivariable analysis. Adults with clinical attachment loss≥ 7 mm and pocket depth PD≥ 6 mm had 2- to 3-fold higher odds of HPV infection.ConclusionsSevere periodontitis was positively associated to oral HPV infection. Longitudinal evaluation of periodontal inflammation's role in acquisition and persistence of oral HPV infection is needed, as periodontitis screening could identify individuals at increased risk of HPV-related oral malignancies.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Periodontitis and oral human papillomavirus infection among Hispanic adults

Ortiz

González

Vivaldi-Oliver

et al. 2018

Papillomavirus Research

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“…Yet meanwhile, national trends show significant increases in HPV-related HNSCCs [13,14], particularly among non-Hispanic white and black males [15]. These trends correlate with increases in sexual behaviors associated with oral HPV infection [16,17], with the strongest associations among men [18]. …”

Section: Introductionmentioning

confidence: 99%

Measures of economic advantage associated with HPV-positive head and neck cancers among non-Hispanic black and white males identified through the National Cancer Database

Peterson

Khosla

Jefferson

et al. 2017

Cancer Epidemiology

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Background National trends show dramatic increases in the incidence of HPV-related head and neck squamous cell carcinomas (HNSCCs) among black and white males. Using cases identified through the National Cancer Data Base, we assessed factors associated with HPV 16- or 16/18 positive HNSCCs among non-Hispanic black and white males diagnosed in the U.S. between 2009 and 2013. Methods This sample included 21,524 HNSCCs with known HPV status. Adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression. Results Compared to those with HPV-negative tumors, male patients diagnosed with HPV-positive HNSCCs were non-Hispanic white, younger at diagnosis, lived in zip-code areas with higher median household income and higher educational attainment, had private health insurance and no reported comorbidities at diagnosis. Although the risk of HPV-positive HNSCCs increased with measures of higher area-level socioeconomic status, the effect was stronger for non-Hispanic black males (RRAdjusted = 1.76, 95% CI 1.49–2.09) than for whites (RRAdjusted = 1.12, 95% CI 1.08–1.16). The peak age for diagnosis of HPV-positive HNSCCs occurred in those diagnosed at 45–49 years (RRAdjusted = 1.57, 95% CI 1.42–1.73). Oropharyngeal tumors were strongly associated with HPV-positivity (RRAdjusted = 4.32, 95% CI 4.03–4.63). In the analysis restricted to oropharyngeal anatomic sites, similar patterns persisted. Conclusion In our analysis, measures of economic advantage were associated with an increased risk of HPV-positive HNSCCs. In order to develop effective interventions, greater understanding of the risk factors for HPV-positive HNSCCs is needed among both high-risk males and their healthcare providers.

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“…The behavioral risk factor for HPV-OPC is oral sex. 7 Not surprisingly, a Dutch study found that women with a history of cervical intraepithelial neoplasia 3 had an increased, long-term risk for HPV-OPC compared with matched controls. 8 Patients with HPV-OPC are also less likely to be users of tobacco products and/or alcohol and have a higher functional status.…”

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confidence: 99%

The Role of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma

Ducatman

2018

Archives of Pathology &Amp; Laboratory Medicine

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- The incidence of HPV-OPC is rising globally and in the United States, but rates of HPV-positivity vary with the anatomic site(s) and the population studied, as well as the method of detecting HPV infection. These tumors are more common in men. In contrast to HPV OPC, the rates of smoking and alcohol abuse are lower. The HPV 16 subtype is predominant, and immunohistochemistry staining for p16 and in situ hybridization are the most widely used methods clinically to detect transcriptionally active HPV. Moreover, HPV-OPC has a unique tumor phenotype with predominantly nonkeratinizing morphology and a variety of patterns. These cancers often present with cystic lymph node metastases. The prognosis for HPV-OPC is significantly better than HPV OPC and has led to differences in grading, staging, and management. Although there are similarities to cervical cancer, there are challenges in preventing such cancers.

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Predictors of high‐risk and low‐risk oral HPV infection in the United States

Abstract: 4. Laryngoscope, 126:1365-1372, 2016.

Cited by 15 publications

References 21 publications

Periodontitis and oral human papillomavirus infection among Hispanic adults

Periodontitis and oral human papillomavirus infection among Hispanic adults

Measures of economic advantage associated with HPV-positive head and neck cancers among non-Hispanic black and white males identified through the National Cancer Database

The Role of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma

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