Daniela Pinter, Stuart J. Ritchie, Thomas Gattringer, Mark E. Bastin, Maria del C. Valdés Hernández, Janie Corley, Susana Muñoz Maniega, Alison Pattie, David A. Dickie, Alan J. Gow, John M. Starr, Ian J. Deary, Christian Enzinger, Franz Fazekas et al.
Abstract:We aimed to assess whether and how changes in brain volume and increases in white matter hyperintensity (WMH) volume over three years predict gait speed and its change independently of demographics, vascular risk factors and physical status. We analyzed 443 individuals from the Lothian Birth Cohort 1936, at mean age 73 and 76 years. Gait speed at age 76 was predicted by age, grip strength and body mass index at mean age 73, three-year brain volume decrease and WMH volume increase, explaining 26.1% of variance.…
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