Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis

Donohoe, Gary; Owens, Nicholas; O'Donnell, Colin; Burke, Teresa; Moore, Loretta; Tobin, Arnold; O’Callaghan, Eadbhard

doi:10.1016/s0924-9338(01)00581-8

Cited by 100 publications

(73 citation statements)

References 14 publications

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“…This analysis was performed by univariate analyses of variance using a critical value of ␣=.008 in light of the comparison of the total score and 5 indexes. We used a multivariate discriminant function analysis 57 to define the components of the RBANS that provided the most significant contribution to the association with the total score. We also determined the Pearson correlation coefficient between the quantitative level of antibodies, expressed as the ratio calculated as described above, and the RBANS total score using a critical value of ␣=.008.…”

Section: Methodsmentioning

confidence: 99%

Association of Serum Antibodies to Herpes Simplex Virus 1 With Cognitive Deficits in Individuals With Schizophrenia

Dickerson

Boronow

Stallings

et al. 2003

Arch Gen Psychiatry

185

118

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Section: Methodsmentioning

confidence: 99%

Association of Serum Antibodies to Herpes Simplex Virus 1 With Cognitive Deficits in Individuals With Schizophrenia

Dickerson

Boronow

Stallings

et al. 2003

Arch Gen Psychiatry

185

118

View full text Add to dashboard Cite

show abstract

“…Studies carried out in recent years have evaluated the complexity of pharmacotherapy in a wide array of diseases, such as epilepsy 5 , schizophrenia 11 , hypertension 12 , type-2 diabetes 13 , HIV/AIDS 3,6 and specific population groups such as the elderly [14][15][16] , polymedicated patients 1 and renal transplanted patients 17 . Some of these studies have demonstrated that the critical points of the complexity of pharmacotherapy can vary depending on the patients' characteristics, such as, for instance, the use of 12 or more doses of medications per day in elderly patients 15 or the dietary restrictions imposed by the administration of the medications in HIV-positive patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Tradução e validação para o português do Medication Regimen Complexity Index

Melchiors¹,

Correr²,

Fernández-Llimós

2007

Arq. Bras. Cardiol.

108

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SummaryBackground: The complexity of pharmacotherapy is a result of a multiplicity of prescribed regimen factors, including the number of different drugs in the regimen, the number of dosage units per dose, the total number of prescribed doses per day and administration instructions. The Medication Regimen Complexity Index (MRCI) is a specific, reliable and valid tool used to measure the complexity of pharmacotherapy, originally developed in English language.

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“…Our operational definitions of mild, moderate, and severe nonadherence are presented in Table 3. This adherence categorization system builds on our previous investigation (24) as well as that of Donohoe et al (25).…”

Section: Nonadherencementioning

confidence: 88%

Risperidone Nonadherence and Return of Positive Symptoms in the Early Course of Schizophrenia

Subotnik

Nuechterlein²,

Ventura³

et al. 2012

FOC

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Objective-This study examined the effect of medication nonadherence on the return of positive symptoms among recent-onset schizophrenia patients.Method-Three sets of operational criteria for medication nonadherence with differing levels of severity were compared for their ability to predict relapse. Explicit operational criteria are provided with the hope that they will be adopted by others. Psychotic symptoms were prospectively rated on a frequent basis, and systematic criteria were applied using a computer scoring program to identify periods of psychotic symptom return. In addition, a specialized statistical survival analysis method, optimal for examining risk periods and outcomes that can recur during the follow-up assessment, was used.Results-As hypothesized, medication nonadherence robustly predicted a return of psychotic symptoms during the early phase of schizophrenia (hazard ratios=3.7-28.5, depending on the severity of nonadherence). Conclusions-Even brief periods of partial nonadherence lead to greater risk of relapse thanwhat is commonly assumed. Patients in the early phase of schizophrenia should be cautioned about the possible consequences of partial or relatively brief periods of antipsychotic medication nonadherence.Nonadherence to antipsychotic medication is quite common among schizophrenia patients and is the greatest obstacle to recovery and relapse prevention. This issue is heightened among individuals with a recent onset of schizophrenia who are just beginning to come to terms with having a psychiatric disorder and have not been in treatment long enough to recognize the necessity of adhering to their medication regimen (1). Approximately 50% of patients discontinue antipsychotic medication or have significant nonadherence to their Address correspondence and reprint requests to Dr. Subotnik, University of California, Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, 300 UCLA Medical Plaza, Rm. 2240, Los Angeles, CA 90095-6968; ksubotnik@mednet.ucla.edu. HHS Public AccessAuthor manuscript Am J Psychiatry. Author manuscript; available in PMC 2016 October 19. Published in final edited form as: Am J Psychiatry. 2011 March ; 168(3): 286-292. doi:10.1176/appi.ajp.2010.09010087. Author Manuscript Author Manuscript Author ManuscriptAuthor Manuscript medication regimen within 1 year of beginning treatment, with rates rising to 75% within 2 years (2). Some evidence indicates that nonadherence is greater in the early course of the disorder (3). The clinical implications of nonadherence among first-episode patients are dramatic. Morken et al. (4) demonstrated an odds ratio of 10.3 for psychotic relapse among nonadherent first-episode patients. In another study of first-episode schizophrenia patients, those who discontinued their medication had an almost fivefold increase in the risk for a first and second relapse (5). Üçok et al. (6) demonstrated that first-episode schizophrenia patients who experienced a psychotic relapse h...

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Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis

Abstract: These data emphasise the complexity of factors that influence whether a person adheres to his medication regimen. Furthermore, they suggest that these factors may vary within the same person over time.

Cited by 100 publications

References 14 publications

Association of Serum Antibodies to Herpes Simplex Virus 1 With Cognitive Deficits in Individuals With Schizophrenia

Association of Serum Antibodies to Herpes Simplex Virus 1 With Cognitive Deficits in Individuals With Schizophrenia

Tradução e validação para o português do Medication Regimen Complexity Index

Risperidone Nonadherence and Return of Positive Symptoms in the Early Course of Schizophrenia

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