Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: The GOASIA study

Pitisuttithum, Panyavee; Chan, Wah Kheong; Piyachaturawat, Panida; Imajo, Kento; Nakajima, Atsushi; Seki, Yosuke; Kasama, Kazunori; Kakizaki, Satoru; Fan, Jian Gao; Song, Myeong Jun; Yoon, Seung Kew; Dan, Yock Young; Lesmana, Laurentius M. Adrianto; Ho, Khek Yu; Goh, Khean Lee; Wong, Vincent W. S.; Treeprasertsuk, Sombat

doi:10.21203/rs.2.13168/v3

Cited by 11 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pitisuttithum et al . reported similar results among 1008 Asian patients with NAFLD from eight countries 9 . Age was strongly associated with NAFLD‐related fibrosis, and elderly patients (age ≥ 60 years) had a significantly higher rate of advanced fibrosis (13.3% vs 35.4%; P < 0.001).…”

mentioning

confidence: 55%

See 1 more Smart Citation

Are low triglyceride levels the cause or an outcome of advanced liver fibrosis in elderly patients with nonalcoholic fatty liver disease?

Kogiso

Hashimoto²

2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

mentioning

confidence: 55%

“…Regarding risk factors for fibrosis, Pitisuttithum et al . reported that female gender and hypertension were predictive of advanced fibrosis in a large cohort of elderly subjects 9 . Chen et al .…”

mentioning

confidence: 99%

Are low triglyceride levels the cause or an outcome of advanced liver fibrosis in elderly patients with nonalcoholic fatty liver disease?

Kogiso

Hashimoto²

2020

J of Gastro and Hepatol

View full text Add to dashboard Cite

“…Third, this study is limited by the overrepresentation of females (72%) in the health examination database, which may be seen as a selection bias to our study. However, this may be explained by a previous study that indicated an association between NAFLD and female sex (7). Nevertheless, there is con icting data about the association of sex and prevalence of NAFLD (27), since the true prevalence of NAFLD is di cult to predict.…”

Section: Strengths and Limitationsmentioning

confidence: 96%

“…There have been previous studies (6,7) regarding the association between certain risk factors for NAFLD, such as female sex, hypertension, and serum glycated hemoglobin (HbA1c). Elderly patients have a higher risk of liver-related disease and death (2).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with hepatic fibrosis and its deterioration among fatty liver elderly: a retrospective cohort study

Lien¹,

Lin²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundThe progression of hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) constitutes a major concern in public health as it is associated with many liver-related complications and mortalities such as cirrhosis, varices, or the development of liver cancer. The purpose of this study was to identify predictive factors that deteriorated the degree of hepatic fibrosis, using the FIB-4 score, in elderly NAFLD patients.MethodsWe collected data from a health examination database. Background information, including demographic characteristics, biochemical blood tests, blood pressures, body mass index (BMI), and abdominal sonography, was collected. We compared the FIB-4 scores from patients’ first and last visits at their health check-up, and multiple logistic regression models with 95% confidence intervals (CI) were used for adjusting covariates to test the risk factors for deterioration of the FIB-4 scores.Results:A total of 742 patients with NAFLD were included in this study, and 534 (72%) were female. The average age and BMI were 71.8 ± 5.6 years and 26.1 ± 3.0 kg/m2, respectively. We divided the population based on mild, moderate, and severe hepatic fibrosis groups according to their FIB-4 scores. Patients with severe FIB-4 scores had a baseline total cholesterol and low-density lipoprotein (LDL) lower than the mild and moderate group (p<0.05), and fasting glucose was higher in the mild versus moderate group (p<0.05). After adjusting for covariates, dyslipidemia, including higher serum levels of LDL (odds ratio [OR]:1.02, CI: 1.00-1.03) and log-triglyceride (OR: 1.68, CI: 1.15-2.45), lower levels of log-high-density lipoprotein (OR:1.68, CI: 1.16-2.42), and longer follow-up years (OR:1.17, CI: 1.08-1.27) were factors that deteriorated the FIB-4 scores.ConclusionsOur study concluded that FIB-4 scores increased over time, and dyslipidemia was a major deteriorating factor for hepatic fibrosis. Therefore, elderly patients with NAFLD should be regularly followed-up and assessed for dyslipidemia to prevent further deterioration of hepatic fibrosis.

show abstract

“…Mcpherson and colleagues also suggested that 2.0 of low COI in 65 years or older [80]. On data of 1008 patients with NAFLD from nine centers across eight countries (The Gut and Obesity in Asia (GOASIA) Workgroup), NITs such as APRI, NFS, and FIB-4 index had a lower specificity in elderly (AUROC 0.62-0.65) [82]. Female (OR: 3.21; 95% CI 1.37-7.54] and hypertension (OR 3.68; 95%CI 1.11-12.23) were predicting factors for advanced fibrosis in the elderly [82].…”

Section: Drawbacks Of Fib-4 Indexmentioning

confidence: 99%

FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “

Sumida¹,

Yoneda²,

Tokushige³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

The prevalence of obesity or metabolic syndrome is increasing worldwide (“Globally metabodemic”). Approximately 25% of adult general population is suffering from nonalcoholic fatty liver disease (NAFLD) which has become serious health problem. Hepatic fibrosis is the most significant determinant of all cause and liver -related mortality in NAFLD. Noninvasive test (NIT) should be urgently required to evaluate hepatic fibrosis in NAFLD. Fibrosis-4 (FIB-4) index is the 1st triaging tool for excluding advanced fibrosis because of its accuracy, simplicity, and cheapness especially for general physicians or endocrinologists, although FIB-4 index has several drawbacks. Accumulating evidence has suggested that vibration controlled transient elastography (VCTE) and the enhanced liver fibrosis (ELF) test may become useful as the 2nd step after triaging by FIB-4 index. The leading cause of mortality in NAFLD is cardiovascular disease (CVD), extrahepatic malignancy, and liver-related diseases. NAFLD often complicates chronic kidney disease (CKD), resulting in increased simultaneous liver kidney transplantation (SLKT). FIB-4 index could be a predictor of not only liver-related mortality and incident hepatocullar carcinoma (HCC) but also prevalent and incident CKD, CVD, and extrahepatic malignancy. Although NITs as milestones for evaluating treatment efficacy have never been established, FIB- 4 index is expected to reflect histological hepatic fibrosis after treatment in several longitudinal studies. We here review the role of FIB-4 index as 1st step NIT in management of NAFLD.

show abstract

Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease: The GOASIA study

Cited by 11 publications

References 29 publications

Are low triglyceride levels the cause or an outcome of advanced liver fibrosis in elderly patients with nonalcoholic fatty liver disease?

Are low triglyceride levels the cause or an outcome of advanced liver fibrosis in elderly patients with nonalcoholic fatty liver disease?

Factors associated with hepatic fibrosis and its deterioration among fatty liver elderly: a retrospective cohort study

FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “

Contact Info

Product

Resources

About