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Cited by 232 publications
(181 citation statements)
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References 36 publications
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“…NAFLD is the most common growing public health problem worldwide presenting a wide spectrum of conditions ranging from fatty liver, that in general follows a benign nonprogressive clinical course, to nonalcoholic steatohepatitis (NASH), a serious form of NAFLD, that may progress to cirrhosis and end-stage liver disease with an increasing incidence in obesity, hyperlipidemia and insulin resistance (higher than normal insulin concentrations are needed to achieve normal metabolic responses) [1,11,19]. In this regard, fatty liver disease is a major contributor to cardiovascular and overall obesity-related morbidity and mortality [20].…”
Section: Discussionmentioning
confidence: 99%
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“…NAFLD is the most common growing public health problem worldwide presenting a wide spectrum of conditions ranging from fatty liver, that in general follows a benign nonprogressive clinical course, to nonalcoholic steatohepatitis (NASH), a serious form of NAFLD, that may progress to cirrhosis and end-stage liver disease with an increasing incidence in obesity, hyperlipidemia and insulin resistance (higher than normal insulin concentrations are needed to achieve normal metabolic responses) [1,11,19]. In this regard, fatty liver disease is a major contributor to cardiovascular and overall obesity-related morbidity and mortality [20].…”
Section: Discussionmentioning
confidence: 99%
“…Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide nowadays affecting 20-30 % of adults in developed countries and up to 80 % of obese people [1]. NAFLD is defined as an excessive accumulation of fat in the liver leads to chronic liver injury in which at least 5 % of hepatocytes display lipid droplets that exceed 5-10 % of liver weight in patients who do not consume significant amounts of alcohol [2,3].…”
Section: Introductionmentioning
confidence: 99%
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“…133 Weight gain is a strong predictor for the development of NAFLD and obesity associates with increased risk of NASH, fibrosis and HCC. [134][135][136][137] However, a recent metaanalysis of paired biopsies failed to show obesity as a risk factor for fibrosis progression. 91 Type of fat and its distribution are more important than fat amount.…”
Section: Visceral Obesitymentioning
confidence: 99%
“…1,[5][6][7] Therefore, epigenetic modifications, either inherited or induced by lifestyles, 8,9 may play a key role in the pathogenesis of the disease. To some extent, the epigenetic mechanisms resulting in aberrant histone modifications, differences in DNA methylation, and dysregulation of microRNAs are the ones that have been related to NAFLD and its transition to more advanced stages.…”
Section: Introductionmentioning
confidence: 99%