Predictor of Early Mortality for Severe Heart Failure Patients With Left Ventricular Assist Device Implantation

DuraHeart^TM Magnetically Levitated Left Ventricular Assist Device

“…Because preoperative ECMO support and end-organ dysfunction have been shown to be significant risk factors for RVAD requirement, 4 the indications regarding an implantable LVAD for such critical cases should be carefully considered. [17][18][19] The other important long-term complication following LVAD implantation is the development of AI. The incidence of significant AI after HeartMate II implantation has been reported to be 52%, with a median time to AI development of 187 days.…”

Left ventricular assist devices in patients with renal dysfunction: where are we heading?

“…Haglund and colleagues found that those with GFR < 45 mL/min/ 1.73 m 2 were less likely to survive after heart transplantation [4]. In additional analyses, baseline creatinine clearance (CrCl) < 47 cc/min and creatinine (Cr) > 1.96 mg/dL have been associated with increased mortality risk after implantation [5,6]. While these findings highlight the challenges of managing advanced HF patients with concomitant renal failure, low kidney function prior to implantation may not necessarily exclude LVADs as a therapeutic option.…”

“…Even though preoperative renal impairment is associated with increased mortality [3][4][5][6], renal function may improve after LVAD implantation [7][8][9][10] and contribute to better survival [3,5,[11][12][13]. With much discussion in the literature regarding patient selection for LVADs [14], the present editorial offers a perspective on the clinical relevance of pre-LVAD renal function as well as post-LVAD changes in kidney function.…”

How Can We Predict Reversibility of Organ Dysfunction After Implantation of Left Ventricular Assist Device?

“…4, 5 Yoshioka et al reported that the cumulative survival curve after LVAD implantation mainly depends on the existence of renal dysfunction rather than on extracorporeal membrane oxygenation (ECMO) support. 6 Therefore, LVAD implantation should be considered without delay if further deterioration of end-organ dysfunction is noted even with ECMO support.…”