Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology

Aleyasin, Ashraf; Hosseini, Marzieh Agha; Mahdavi, Atossa; Safdarian, Leila; Fallahi, Parvin; Mohajeri, Mohammad; Abbasi, Mohammad Reza; Esfahani, Fatemeh

doi:10.1016/j.ejogrb.2011.07.006

Cited by 133 publications

(129 citation statements)

References 23 publications

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“…Unlike the previously discussed studies, Aleyasin et al [67] found no relationship between serum vitamin D concentration and fertilization, implantation, or pregnancy rates in their study of 82 Iranian women. Similar to Ozkan et al [69], subjects were evaluated by tertiles according to vitamin D level [67].…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 55%

“…When logistic regression analysis was applied, FF vitamin D levels were not shown to be an independent predictor of CP. While the small sample size and largely vitamin D deficient population in this study [67] make it difficult to draw any solid conclusions, the high fertilization rates demonstrated in this population suggests that vitamin D stores may not be a player in infertility.…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 77%

“…Similar to Ozkan et al [69], subjects were evaluated by tertiles according to vitamin D level [67]. Interestingly, the fertilization rates in all tertiles were exceptionally high (79.0, 67.8, and 68.3 %, from lowest to highest tertiles).…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 84%

“…Only eight of the 34 articles retrieved from PubMed met criteria (Fig. 2) [66][67][68][69][70][71][72][73]. Reference lists of chosen studies and narrative reviews were cross-referenced to find additional studies.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…A societal perspective was employed and only estimated direct costs were considered. Vitamin D deficiency was defined as <20 ng/mL in accordance with the Endocrine Society guidelines [7], and also consistent with the definition utilized by the majority the trials included in this review [67][68][69][70][71][72]. The study by Polyzos et al [73] was selected for utilization of clinical pregnancy and ongoing pregnancy rates for mathematical modeling secondary to reporting the largest cohort, recency of publication and attempting to control for embryo quality and quantity by including single blastocyst ART cycles only.…”

Section: Cost-benefit Analysismentioning

confidence: 99%

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Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 55%

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 77%

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 84%

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Section: Cost-benefit Analysismentioning

confidence: 99%

See 3 more Smart Citations

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Nutrition in Human Fertility

Chavarro

Cardozo

Afeiche

2015

Obesity and Fertility

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Identifying the extent to which modifi able lifestyle factors infl uence human fertility is of major clinical and public health signifi cance. It is estimated that more than fi ve million children have been born worldwide as a result of assisted reproduction [ 1 ]. In 2010 alone, there were nearly 150,000 assisted reproduction cycles resulting in more than 47,000 deliveries and the birth of 61,564 children in the United States [ 2 ]. These impressive fi gures notwithstanding, the number of subfertile couples benefi ting from these therapies represents approximately one tenth of those estimated to meet the clinical defi nition of infertility and about 2 % of women estimated to be unable to get pregnant or carry a pregnancy to term nationwide [ 3 ]. This vast gap alone highlights the need to identify strategies to address infertility that do not rely solely on clinical interventions and can be implemented on a population-wide level.On the other hand, there is a critical need to further improve success rates of infertility treatments. While the proportion of live births per initiated assisted reproduction cycle in the United States improved gradually through the 1990s, it has remained steady, at about 30 %, for almost a decade (Fig. 4.1 ). Unfortunately, very few predictors of successful infertility treatment are known and the strongest and best-characterized risk factor for unsuccessful infertility treatment, age [ 4 , 5 ], is not modifi able. Moreover, the proportion of women delaying childbearing into their 30s and beyond 35 years has increased dramatically in the United States and other Western nations [ 6 ]. These facts highlight the need to identify potentially modifiable factors associated with fertility treatment outcomes. Emerging evidence further suggests that diet, a potentially modifi able factor, could have a major impact on human fertility independent of body weight. In this chapter we will review and summarize the current evidence linking diet to fertility in women and men, and to outcomes of infertility treatment. Diet and Female FertilityInterest in the role of diet on female fertility is longstanding. There are reports of animal models evaluating the effects of micronutrient defi ciencies on ovulatory function as early as the 1960s [ 7 ] and prospective studies in humans evaluating the role of other dietary factors on fertility since the 1980s [ 8 ]. Most of the existing literature revolves around the potential role of two purported reproductive toxicants on fertility, caffeine, and alcohol, and is plagued with poor quality research. Recent fi ndings, however, suggests that the role of diet on human fertility and on conditions associated with infertility may be much broader. Most of the interest in evaluating the role of caffeine on reproductive performance in general and on fertility in particular can be traced back to a series of experiments in rodents which documented an increased frequency of fetal resorption and congenital malformations of the skeleton in rats receiving caffeine via oral intub...

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