Predictive value of early structural changes on radiographs and MRI for incident clinical and radiographic knee osteoarthritis in overweight and obese women

Bijen, Claudia B M; Runhaar, Jos; Rijkels-Otters, Joanne Bernadine Marie; Oei, E.H.; Bierma-Zeinstra, S.M.

doi:10.1016/j.semarthrit.2018.02.015

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Compared to participants with neither MRI-OA nor ROA, knee structural abnormalities at baseline were more frequently observed in OA patients meeting either the MRI or radiographic definition and were most common in those who met both definitions. Given that MRI is more sensitive to structural changes than radiographs 2 , the magnitude of difference (7%) in the prevalence of MRI-OA and ROA is perhaps less than we would expect, although it is similar to the differences seen in other studies of 4.7e8.3% 17,30 . Moreover, the sensitivity of MRI-OA for ROA in our study was only moderate (62%) and similar to that in other studies 30,31 .…”

Section: Discussionsupporting

confidence: 74%

“…Given that MRI is more sensitive to structural changes than radiographs 2 , the magnitude of difference (7%) in the prevalence of MRI-OA and ROA is perhaps less than we would expect, although it is similar to the differences seen in other studies of 4.7e8.3% 17,30 . Moreover, the sensitivity of MRI-OA for ROA in our study was only moderate (62%) and similar to that in other studies 30,31 . This and the fact it failed to identify a substantial number of participants with definite ROA (grade !…”

Section: Discussionsupporting

confidence: 74%

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Comparison of radiographic and MRI osteoarthritis definitions and their combination for prediction of tibial cartilage loss, knee symptoms and total knee replacement: a longitudinal study

Cai

Cicuttini

Aitken

et al. 2020

Osteoarthritis and Cartilage

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Objective: To describe the value of radiographic-and magnetic resonance imaging (MRI)-defined tibiofemoral osteoarthritis (ROA and MRI-OA, respectively) and in combination for predicting tibial cartilage loss, knee pain and disability and total knee replacement (TKR) in a population-based cohort. Design: A radiograph and 1.5T MRI of the right knee was performed. ROA and MRI-OA at baseline were defined according to the Osteoarthritis Research Society International atlas and a published Delphi exercise, respectively. Tibial cartilage volume was measured over 2.6 and 10.7 years. Knee pain and disability were assessed at baseline, 2.6, 5.1 and 10.7 years. Right-sided TKRs were assessed over 13.5 years. Results: Of 574 participants (mean 62 years, 49% female), 8% had ROA alone, 15% had MRI-OA alone, 13% had both ROA and MRI-OA. Having ROA (vs. no ROA) and MRI-OA (vs. no MRI-OA) predicted greater tibial cartilage loss over 2.6 years (À75.9 and À86.4 mm 3 /year) and higher risk of TKR over 13.5 years (Risk Ratio [RR]: 15.0 and 10.9). Only MRI-OA predicted tibial cartilage loss over 10.7 years (À7.1 mm 3 /year) and only ROA predicted onset and progression of knee symptoms (RR: 1.32e1.88). In participants with both MRI-OA and ROA, tibial cartilage loss was the greatest (over 2.6 years: À116.1 mm 3 /year; over 10.7 years: À11.2 mm 3 /year), and the onset and progression of knee symptoms (RR: 1.75e2.89) and risk of TKR (RR: 50.9) were the highest. Conclusions: The Delphi definition of MRI-OA is not superior to ROA for predicting structural or symptomatic OA progression but, combining MRI-OA and ROA has much stronger predictive validity.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 74%

Comparison of radiographic and MRI osteoarthritis definitions and their combination for prediction of tibial cartilage loss, knee symptoms and total knee replacement: a longitudinal study

Cai

Cicuttini

Aitken

et al. 2020

Osteoarthritis and Cartilage

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“…Osteoarthritis is common in older people in the general population, leading to pain, joint instability, limitations in daily activities and decreased quality of life. 42 43 Little is known about the prevalence of knee and hip osteoarthritis in people with ID. High prevalence is expected because many factors that have been associated with osteoarthritis (such as obesity, poor physical fitness levels, poor motor skills, gait abnormalities, musculoskeletal complications and developmental problems) are more common in adults with ID than in the general population.…”

Section: Methods and Analysismentioning

confidence: 99%

“…The 10-year follow-up will also focus on musculoskeletal disorders, in particular osteoarthritis. Osteoarthritis is common in older people in the general population, leading to pain, joint instability, limitations in daily activities and decreased quality of life 42 43. Little is known about the prevalence of knee and hip osteoarthritis in people with ID.…”

Section: Methods and Analysismentioning

confidence: 99%

Healthy Ageing and Intellectual Disability study: summary of findings and the protocol for the 10-year follow-up study

et al. 2022

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IntroductionThe Healthy Ageing and Intellectual Disability (HA-ID) study is a prospective multicentre cohort study in the Netherlands that started in 2008, including 1050 older adults (aged ≥50) with intellectual disabilities (ID). The study is designed to learn more about the health and health risks of this group as they age. Compared with the amount of research in the general population, epidemiological research into the health of older adults with ID is still in its infancy. Longitudinal data about the health of this vulnerable and relatively unhealthy group are needed so that policy and care can be prioritised and for guiding clinical decision making about screening, prevention and treatment to improve healthy ageing.Methods and analysisThis article presents a summary of the previous findings of the HA-ID study and describes the design of the 10-year follow-up in which a wide range of health data will be collected within five research themes: (1) cardiovascular disease; (2) physical activity, fitness and musculoskeletal disorders; (3) psychological problems and psychiatric disorders; (4) nutrition and nutritional state; and (5) frailty.Ethics and disseminationEthical approval for the 10-year follow-up measurements of the HA-ID study has been obtained from the Medical Ethics Review Committee of the Erasmus MC, University Medical Centre Rotterdam (MEC-2019-0562).Trial registration numberThis cohort study is registered in the Dutch Trial Register (NTR number NL8564) and has been conducted according to the principles of the Declaration of Helsinki.

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Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial

Schnitzer¹,

Pueyo²,

Deckx³

et al. 2023

Osteoarthritis and Cartilage

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Predictive value of early structural changes on radiographs and MRI for incident clinical and radiographic knee osteoarthritis in overweight and obese women

Cited by 4 publications

References 34 publications

Comparison of radiographic and MRI osteoarthritis definitions and their combination for prediction of tibial cartilage loss, knee symptoms and total knee replacement: a longitudinal study

Comparison of radiographic and MRI osteoarthritis definitions and their combination for prediction of tibial cartilage loss, knee symptoms and total knee replacement: a longitudinal study

Healthy Ageing and Intellectual Disability study: summary of findings and the protocol for the 10-year follow-up study

Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial

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