Predictive value of d-dimer/albumin ratio and fibrinogen/albumin ratio  for in-hospital mortality in patients with COVID-19

Küçükceran, Kadir; Ayrancı, Mustafa Kürşat; Girisgin, Sadik; Koçak, Sedat

doi:10.22541/au.161606548.88251239/v2

Cited by 10 publications

(13 citation statements)

References 18 publications

(32 reference statements)

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“…Similarly in our research, when the fibrinogen to albumin ratio was considered, it was found to be 0.24 ± 0.3 in 272 patients who died, and 0.11 ± 0.6 in 275 patients who were recovered ( P = .000). In a recent study conducted in COVID‐19 patients, a correlation was found between high FAR and mortality, mentioning that FAR could be a better mortality predictor than fibrinogen alone 40 . In addition, the ROC analysis performed in our study shows that FAR is more sensitive and specific than fibrinogen, CRP and albumin in determining mortality.…”

Section: Discussionsupporting

confidence: 64%

Predictive role of FAR ratio in COVID‐19 patients

Çekiç

Arman

Genç

et al. 2021

Int J Clinical Practice

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Objective No effective treatment has yet been found for SARS‐Cov‐2, which caused a pandemic outbreak in 2019. It is crucial to detect the progression of COVID‐19 in patients as early as possible. Fibrinogen to albumin ratio (FAR) has been used as a new inflammatory marker. We aimed to find out whether the use of the FAR as a predictor of mortality in COVID‐19 patients provides clinical benefit. Materials and Methods Data from 590 patients with COVID‐19 from March 15, 2020 to January 15, 2021 in medicine wards and intensive care units (ICU) were retrospectively analysed. Demographic data and other laboratory markers were collected from the electronic medical records. Relationship between FAR was investigated between patients in the survivor/non‐survivor patients. Findings The mean FAR levels in patients who were non‐survivor was 24.44 ± 30.3 (n = 272 and 11.29 ± 6.29 (n = 275) (P = .000) in patients survivor COVID‐19 infection. In ROC curve for FAR, the threshold FAR that may pose a risk for mortality was determined as 13.84 ((AUC: 0.808 (0.771‐0.844)); 74.9% sensitivity, 74.6% specificity; P = .000)). Result As a result of this study, increased FAR were found to be important markers in determining the mortality levels in COVID‐19 patients.

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Section: Discussionsupporting

confidence: 64%

Predictive role of FAR ratio in COVID‐19 patients

Çekiç

Arman

Genç

et al. 2021

Int J Clinical Practice

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“…Fibrinogen to albumin ratio (FAR) [49][50][51] and Urea to albumin ratio (UAR) [52][53][54] were studied in community-acquired pneumonia patients in some previous studies, and high FAR and UAR values were found to be associated with mortality. In a study conducted in COVID 19 patients, increased UAR ratio 55 and increased FAR 56 were associated with increased mortality risk. In our study, inflammatory biomarkers (CAR, NLR, FAR, and UAR) were found to have a statistically significant relationship with mortality while the AUC value of CAR was the highest in the ROC analysis for mortality.…”

Section: Discussionmentioning

confidence: 95%

C-reactive protein to albumin ratio is associated with increased risk of mortality in COVID-19 pneumonia patients

Acehan

Gülen

Isıkber

et al. 2021

Cukurova Medical Journal

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Öz Purpose: The aim of this retrospective observational study is to compare C-reactive protein to albumin ratio and CURB-65 score in the emergency department in terms of predicting mortality in patients over the age of 18 who were hospitalized for COVID-19 pneumonia. Materials and Methods: The study includes 613 patients hospitalized between March 15 and April 30, 2020 due to COVID-19 pneumonia detected on thorax computed tomography at the emergency department pandemic area. Hospitalized patients were divided into groups according to positive and negative real-time polymerase chain reaction results. Results: While 73.1% (n: 448) of 613 patients included in the study were hospitalized in the ward, 26.9% (n: 165) were hospitalized in intensive care. 8.6% (n: 53) of the total patients died. In non-survivors patients the mean CURB 65 score was 4±1 (and C-Reactive Protein to Albumin Ratio was 5.6±4.2 Multivariate logistic regression analysis showed that CURB 65 and high C-Reactive Protein to Albumin Ratio are independent risk factors for COVID-19 pneumonia. Conclusion: The C-reactive protein to albumin ratio is as sensitive as CURB 65 and can guide the clinician in the early detection of patients with poor prognosis COVID-19 pneumonia. Amaç: Bu retrospektif gözlemsel çalışmanın amacı, COVID-19 pnömonisi nedeniyle hastaneye yatırılan 18 yaş üstü hastalarda mortaliteyi öngörme açısından acil serviste bakılan C-reaktif protein/albumin oranı ile CURB-65 skorunun karşılaştırılmasıdır. Gereç ve Yöntem: Çalışma 15 Mart-30 Nisan 2020 tarihleri arasında acil servis pandemi alanında toraks bilgisayarlı tomografisinde COVID-19 pnömonisi tespit edilerek hastaneye yatırılan 613 hastayı kapsamaktadır. Hastanede yatan hastalar pozitif ve negatif gerçek zamanlı polimeraz zincir reaksiyonu sonuçlarına göre gruplara ayrıldı. Bulgular: Çalışmaya dahil edilen 613 hastanın %73,1'i (n:448) serviste yatarken, %26,9'u (n:165) yoğun bakımda yatmaktaydı. Toplam hastaların %8,6'sı (n:53) öldü. Ölen hastalarda CURB 65 skoru ortalama 4±1 ve C-reaktif protein/albümin oranı 5.6±4.2 idi.. Çok değişkenli lojistik regresyon analizi, CURB 65 skorunu) ve yüksek C-reaktif protein/albümin oranı olduğunu gösterdi.) COVID-19 pnömonisi için bağımsız risk faktörleri olarak göstermiştir. Sonuç: C-reaktif protein/albumin oranı, kötü prognozlu COVID-19 pnömonisi olan hastaların erken tespitinde CURB 65 kadar duyarlı olup klinisyene yol gösterebilir.

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“…[32][33][34] Küçükceran et al 15 found that DAR, as the ratio of D-dimer to albumin, can serve as a valuable predictor for mortality in COVID-19 patients. 15 However, the present results showed that DAR was similar between non-survivors and survivors among HBV-DeCi patients. Moreover, we did not find that DAR was associated with mortality in univariate analyses, and its predictive ability was inferior to that of the other four markers.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, recent studies showed that elevated plasma D-dimer can predict poor prognosis in patients with liver diseases. [32][33][34] Küçükceran et al 15 found that DAR, as the ratio of D-dimer to albumin, can serve as a valuable predictor for mortality in COVID-19 patients. 15 However, the present results showed that DAR was similar between non-survivors and survivors among HBV-DeCi patients.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased albumin is a common complication in cirrhotic patients that can lead to ascites and hepatic encephalopathy, and even a tendency toward spontaneous bacterial peritonitis, and has a negative impact on prognosis. 10,11 Recently, the clinical usefulness of albumin-related biomarkers available from routine testing has been reported in various diseases, including liver diseases, such as C-reactive protein-to-albumin ratio (CAR), [12][13][14] D-dimer-to-albumin ratio (DAR), 15 prothrombin time-international normalized ratio-to-albumin ratio (PTAR), [16][17][18] neutrophil countto-albumin (NAR), [19][20][21] and blood urea nitrogen-to-albumin ratio (BAR). [22][23][24][25] However, no studies have investigated the differences in prognostic value of these albumin-related ratios in HBV-DeCi patients.…”

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confidence: 99%

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Prognostic value of albumin‐related ratios in HBV‐associated decompensated cirrhosis

Zhang

Shen

2022

Clinical Laboratory Analysis

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Background Identification of effective and accurate prognostic biomarkers for hepatitis B virus‐associated decompensated cirrhosis (HBV‐DeCi) is challenging. This study was designed to determine and compare the prognostic value of albumin‐related ratios (blood urea nitrogen‐to‐albumin ratio [BAR], C‐reactive protein‐to‐albumin ratio [CAR], prothrombin time‐international normalized ratio‐to‐albumin ratio [PTAR], neutrophil count‐to‐albumin ratio [NAR], and D‐dimer‐to‐albumin ratio [DAR]) in HBV‐DeCi patients. Methods We retrospectively recruited 161 HBV‐DeCi patients. Receiver operating characteristic curve, DeLong test, and Cox regression analyses were used to estimate and compare the predictive value of these five albumin‐related ratios and Model for End‐Stage Liver Disease (MELD) score. Results A total of 29 (18.0%) patients had died 30 days after admission. The prognostic roles of CAR, DAR, PTAR, NAR, and BAR in HBV‐DeCi were different. CAR, PTAR, NAR, and BAR were significantly higher in non‐survivors compared with survivors. However, DAR did not differ between the two groups. The predictive power of BAR was superior to that of the other four albumin‐related biomarkers and similar to that of MELD score. On multivariate analysis, BAR and MELD score were identified as independent prognostic factors, and the combination of BAR and MELD score may improve the prognostic accuracy in HBV‐DeCi. Conclusion The present findings suggest that BAR may be a simple and useful prognostic tool to predict mortality in HBV‐DeCi patients.

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Predictive value of d-dimer/albumin ratio and fibrinogen/albumin ratio for in-hospital mortality in patients with COVID-19

Cited by 10 publications

References 18 publications

Predictive role of FAR ratio in COVID‐19 patients

Predictive role of FAR ratio in COVID‐19 patients

C-reactive protein to albumin ratio is associated with increased risk of mortality in COVID-19 pneumonia patients

Prognostic value of albumin‐related ratios in HBV‐associated decompensated cirrhosis

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