Predictive Value of Age and Serum Parathormone and Vitamin D3 Levels for Postoperative Hypocalcemia After Total Thyroidectomy for Nontoxic Multinodular Goiter

Serum PTH and Ionized Calcium Levels as Predictors of Symptomatic Hypocalcemia after Parathyroidectomy

“…They also reported that the risk factors for postoperative secondary hyperparathyroidism included older age, symptomatic hyperparathyroidism, higher preoperative PTH and alkaline phosphatase levels, and lower serum phosphorous levels 8 . Erbil et al, also found that older age, specifically those patients over 50 years was associated with a higher incidence of postoperative hypocalcemia 9 . Although our study was not designed to address the same question, we found that younger patients had a higher tendency to develop symptomatic postoperative hypocalcemia after parathyroidectomy for primary hyperparathyroidism.…”

Is Preoperative Vitamin D Deficiency a Risk Factor for Postoperative Symptomatic Hypocalcemia in Thyroid Cancer Patients Undergoing Total Thyroidectomy Plus Central Compartment Neck Dissection?

“…Hypocalcemia is transient and occurs in 10-50% of patients who undergo TT. However, permanent hypocalcemia lasting more than six months occurs in 0.5-2% of patients (1,2).…”

“…Hence, preoperative vitamin D levels have an impact on the perioperative Ca and PTH kinetics after TT. Recently, some studies have reported that VDD is a risk factor for postoperative hypocalcemia after TT in patients with nontoxic multinodular goiter or Graves' disease (2,5,(14)(15)(16). Moreover, some authors have recommended routine or selective postoperative Ca and vitamin D supplementation in order to lessen the risk of symptomatic hypocalcemia (12,(17)(18)(19)(20)(21).…”

Hypocalcemia: What a Surgeon should know

“…The presence of low preoperative serum 25-hydroxy vitamin D (25-OHD) levels has also been reported to be associated with increased risk of postoperative hypocalcemia in patients who undergo TT. In a study by Erbil et al, 39 the presence of serum 25-OHD levels less than 25 ng/mL (62.5 nmol/L) predicted 15 times increased risk for postoperative hypocalcemia in patients who had undergone TT for nontoxic MNG. Vitamin D deficiency may also decrease the negative predictive value of intraand postoperative iPTH to predict hypocalcemia.…”