Predictive preoperative factors of positivesurgical margins after robotic radical prostatectomy in low-risk prostate cancer

Turan, Turgay; Boylu, Uğur; Başataç, Cem; Gümüş, Eyüp

doi:10.5152/tud.2013.020

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Previously, the factors used to predict PSM after RP in PCa mainly relied on clinical information. Turan et al [ 33 ] identified that a positive core percentage of biopsy specimens, tPSA levels and the elapsed time between biopsy and surgery increased the risk of a PSM. Yang et al [ 11 ] reported that perineural invasion, higher biopsy Gleason scores and more positive cores in biopsy specimens were independent predictors of a PSM.…”

Section: Discussionmentioning

confidence: 99%

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

Wang

et al. 2021

Cancer Imaging

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Purpose To investigate the performance of magnetic resonance imaging (MRI)-based radiomics models for benign and malignant prostate lesion discrimination and extracapsular extension (ECE) and positive surgical margins (PSM) prediction. Methods and materials In total, 459 patients who underwent multiparametric MRI (mpMRI) before prostate biopsy were included. Radiomic features were extracted from both T2-weighted imaging (T2WI) and the apparent diffusion coefficient (ADC). Patients were divided into different training sets and testing sets for different targets according to a ratio of 7:3. Radiomics signatures were built using radiomic features on the training set, and integrated models were built by adding clinical characteristics. The areas under the receiver operating characteristic curves (AUCs) were calculated to assess the classification performance on the testing sets. Results The radiomics signatures for benign and malignant lesion discrimination achieved AUCs of 0.775 (T2WI), 0.863 (ADC) and 0.855 (ADC + T2WI). The corresponding integrated models improved the AUC to 0.851/0.912/0.905, respectively. The radiomics signatures for ECE achieved the highest AUC of 0.625 (ADC), and the corresponding integrated model achieved the highest AUC (0.728). The radiomics signatures for PSM prediction achieved AUCs of 0.614 (T2WI) and 0.733 (ADC). The corresponding integrated models reached AUCs of 0.680 and 0.766, respectively. Conclusions The MRI-based radiomics models, which took advantage of radiomic features on ADC and T2WI scans, showed good performance in discriminating benign and malignant prostate lesions and predicting ECE and PSM. Combining radiomics signatures and clinical factors enhanced the performance of the models, which may contribute to clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

Wang

et al. 2021

Cancer Imaging

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“…The percentage of tumoral involvement in each biopsy core can be another predictor of inferior outcomes. 8 We were not able to assess this relationship in our study due to infrequent documentation of this variable.…”

Section: Discussionmentioning

confidence: 86%

“…There are several studies searching the role of other preoperative factors such as prostate volume, the number of positive cores, the rate of involvement in each core in low or intermediate group. 8 In this study, it was aimed to review the preoperative predictive factors for PSM in patients with low or intermediate risk prostate cancer who underwent retropubic radical prostatectomy in our institution.…”

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confidence: 99%

Assessment of Preoperative Predictive Factors for Positive Surgical Margins in Patients with Low or Intermediate Risk Prostate Cancer Who Underwent Retropubic Radical Prostatectomy

Çoşkun¹,

Ergenekon²

2019

J Reconstr Urol

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Positive surgical margins after radical prostatectomy is important due to increased risk of biochemical recurrence. Preoperative clinical stage, prostate specific antigen (PSA) value and the Gleason Score are the predictors of surgical margin status. In this study we aimed to assess the effects of preoperative variables on surgical margin positivity in patients with low or intermediate risk. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Preoperative clinical stage, PSA value, prostate volume and variables obtained from prostate biopsies of 73 patients who were grouped in low or intermediate risk according to D'Amico criteria (Clinical satge≤ T2b, PSA<10 ng/dl, Gleason Score ≤ 7) were compared with regard to surgical margin positivity status retrospectively. R Re es su ul lt ts s: : The rate of the patients with positive surgical margins was 23.3%. The mean prostate volume was 84.91 ml±21.43 and 56.05 ml±18.42 in negative and positive surgical margin groups, respectively (p=0.001). While 14.6% of the patients with a PSA level <10 ng/dl had positive surgical margins, this rate was 34.4% in the patients with a PSA level of 10-20 ng/dl. (p=0.05). Increased numbers of positive cores in prostate biopsy were related with positive surgical margins (p=0.001). In multivariate analysis, only, prostate volumes less than 70 ml was found to be statistically significant (p=0.023). C Co on nc cl lu us si io on n: : Smaller prostate volumes less than 70 ml. increase the risk of positive surgical margins in patients with low or intermediate risk. K Ke ey yw wo or rd ds s: : Margins of excision; prostatic cancer Ö ÖZ ZE ET T A Am ma aç ç: : Radikal prostatektomi sonrası cerrahi sınırların pozitif olması biyokimyasal rekürrens riskini artırması nedeniyle önemlidir. Operasyon öncesi klinik evre, PSA değeri ve Gleason Skoru pozitif cerrahi sınırlar açısından belirleyici özelliktedir. Bu çalışmada, düşük ve orta risk özellikleriyle radikal prostatektomi uygulanan hastalarda operasyon öncesi verilerin cerrahi sınır pozitifliği üzerine olan etkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön n-t te em ml le er r: : Retrospektif olarak D'Amico kriterlerine göre düşük ve orta risk grubunda (klinik evre ≤ T2b, PSA<10 ng/dl, Gleason Skoru ≤ 7) olan 73 hastanın ameliyat öncesi klinik evre, PSA değeri, prostat hacmi ve prostat biyopsisinden elde edilen verileri pozitif cerrahi sınır saptanmasına göre karşılaştırıldı. B Bu ul lg gu ul la ar r: : Pozitif cerrahi sınır saptanan hastaların oranı %23,3 idi. Ortalama prostat hacmi negatif cerrahi sınır grubunda 84,91 ml±21,43 ve pozitif cerrahi sınır grubunda 56,05 ml±18,42 olarak bulundu (p=0,001). PSA seviyesi 10 ng/dl'den düşük olan hastalarda cerrahi sınır pozitifliği oranı %14,6 bulunurken, PSA seviyesi 10-20 ng/dl arasında olan hastalarda bu oran %34,4 olarak bulundu (p=0,05). Prostat biyopsisinde artmış pozitif kor sayıları pozitif cerrahi sınır ile ilişkili bulundu (p=0,001). Çoklu değişken analizinde ise sadece prostat hacminin 70 ml'den az olması istatistiksel olar...

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Predictive preoperative factors of positivesurgical margins after robotic radical prostatectomy in low-risk prostate cancer

Cited by 2 publications

References 23 publications

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

Assessment of Preoperative Predictive Factors for Positive Surgical Margins in Patients with Low or Intermediate Risk Prostate Cancer Who Underwent Retropubic Radical Prostatectomy

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