Predictive factors of outcome in assisted reproductive technologies

Abstract

Objectives. Study of predictive factors of outcome in assisted reproductive technologies. Material and methods. The retrospective study on a sample that contains information about 1,121 cycles of embryo transfer (ET) from oocytes and sperm autologous procedures. To quantify the relationship between indicators of success and influence factors, a multivariate analysis were used for factors affecting probability of pregnancy (biochemical or clinical) with in vitro fertilization in relation with 14 independent variables (factorial explanatory). Results. Variables with positive influence correlated with biochemical or clinical pregnancy were identified as: type of medication for ovarian stimulation, age of embryo at the day of transfer, number of days of stimulation, number of retrieved oocytes, female age. Conclusion. Study of risk factors and their influence on the success of assisted reproduction technologies may offer new information and could change practice in the field of in vitro fertilization (IVF). Female age, number of days of stimulation and number of retrieved oocytes are predictors for the chance of pregnancy in IVF treatments. More extensive studies are needed, especially studies that focus on the analysis of factors related to embryo quality as predictors of pregnancy in IVF.