Predictive Factors in the Incidence of Cirrhosis in Chronic Hepatitis B Virus Infections

Alavian, Seyed Moayed; Imanieh, Mohammad Hadi; Imanieh, M H

doi:10.5812/hepatmon.34790

Cited by 14 publications

(16 citation statements)

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“…The effect of HBV DNA level on liver fibrosis and cirrhosis is a research hotspot [ 10 – 13 ]. However, the results and conclusions of previous studies have not been consistent [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection

et al. 2018

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BackgroundThere is no consensus regarding the relationship between HBV DNA and liver fibrosis, and the relationship between HBV DNA and the degree of liver cirrhosis has not been reported in patients with chronic HBV infection.MethodsFrom January 2011 to December 2016, liver biopsies were performed on 396 patients with chronic hepatitis B and cirrhosis. Assessments of liver fibrosis and cirrhosis were based on the Laennec staging system.ResultsSerum levels of HBV DNA were correlated with fibrosis and cirrhosis (KW = 73.946, P<0.001). Serum HBV DNA level was correlated with mild fibrosis, moderate to severe fibrosis and cirrhosis (P = 0.009, P<0.001, and P<0.001, respectively). The HBeAg-positive group and HBeAg-negative group showed significant differences in HBV DNA levels, and the rates of mild fibrosis, severe fibrosis and cirrhosis were significantly different between these two groups (F = 17.585, P<0.001 and F = 6.017, P = 0.003, respectively). The replication status of the serum HBV DNA affected fibrosis formation as well as cirrhosis (χ2 = 53.76, P<0.001). In the HBeAg-positive group, the sensitivity, specificity and AUC values of HBV DNA as a predictor for mild fibrosis and cirrhosis were 64.3%, 78.94% and 0.818, respectively, and 81.0%, 69.2%, and 0.871, respectively. In the HBeAg-negative group, the sensitivity, specificity and AUC values of HBV DNA for liver sclerosis prediction were 48%, 76.8% and 0.697, respectively.ConclusionsDifferent HBV DNA levels had different effects on the formation of fibrosis and sclerosis in liver tissues. HBV DNA levels can predict mild fibrosis and cirrhosis in liver tissue, which is enhanced in HBeAg-positive patients.

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Section: Discussionmentioning

confidence: 99%

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection

et al. 2018

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“…The pronounced replication of HBV during CHB has been linked to the development of cirrhosis and hepatocellular carcinoma [23, 24]. Notably, this replication also seems to be affected by host factors.…”

Section: Discussionmentioning

confidence: 99%

Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Shen

et al. 2016

Lipids Health Dis

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BackgroundHepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB). The aim of this study was to investigate the relationship between HBV DNA load in serum and serum apoM levels in patients with CHB.MethodsA total of 73 HBeAg-negative CHB patients, 50 HBeAg-positive CHB patients, and 79 non-CHB controls were included in the study cohort. The age and body mass index (BMI) of the study participants were matched. Serum levels of apoM and the HBV antigens HBsAg and HBeAg were measured by enzyme-linked immunosorbent assay (ELISA) analysis. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), cholesterol, and triglycerides (TG) were assessed using an automatic biochemical analyzer. Serum HBV DNA levels were quantified by real-time PCR analysis. Data were analyzed by Spearman’s rank correlation coefficient, Pearson correlation coefficient, and multivariate linear regression model (continuous variables), or Student’s t-test (mean differences).ResultsBoth the HBeAg-negative CHB and HBeAg-positive CHB patient groups exhibited elevated serum levels of apoM. Moreover, serum apoM levels were positively correlated with serum HBV DNA levels in HBeAg-negative CHB patients (r = 0.394, p < 0.001). Conversely, there was no significant relationship between apoM and HBV DNA levels in the HBeAg-positive CHB group (r = 0.197, p = 0.170). The median log copies/mL value for HBV DNA (4.00) was considered the cutoff point for the HBeAg-negative CHB group. Notably, a significant number of patients with HBV DNA levels above the cutoff point also had higher serum apoM levels (63.38 ± 29.84 vs. 41.41 ± 21.84; p = 0.001).ConclusionsOur findings reveal that the correlation between serum apoM levels and viral loads may depend on HBeAg status, as serum apoM levels were positively correlated with HBV DNA levels in HBeAg-negative CHB patients. These results suggest that HBeAg may play a role in apoM-related lipid metabolism and anti-inflammatory functions in hepatitis B patients. Thus, our findings may facilitate the clinical management of HBV infection.

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“…The progression of chronic HBV or HCV to cirrhosis depends on a number of factors (host and virus). In the case of HBV infection, these factors include; alcohol consumption, smoking, male gender, co-infection with hepatitis C or D virus and HBV genotype (C > B; D > A) [37]. Others are elevated serum levels of total bilirubin, AST/ALT ratio, HBV DNA, and positivity of HBeAg [38,37].…”

Section: Distribution and Determinants Of Complications Of Chronic LImentioning

confidence: 99%

“…In the case of HBV infection, these factors include; alcohol consumption, smoking, male gender, co-infection with hepatitis C or D virus and HBV genotype (C > B; D > A) [37]. Others are elevated serum levels of total bilirubin, AST/ALT ratio, HBV DNA, and positivity of HBeAg [38,37]. Important factors for the progression of chronic HCV infection to cirrhosis include non-modifiable (male sex, age at which infection was acquired, and race), modifiable (alcohol abuse, smoking, insulin resistance, and co-infection with hepatitis B, HIV or schistosomiasis) [39] and HCV genotypes (HCV 2 <HCV 4 <HCV 1 <HCV 3) [40].…”

Section: Distribution and Determinants Of Complications Of Chronic LImentioning

confidence: 99%

Distribution and Determinants of Etiologies and Complications of Chronic Liver Diseases Among Patients at a Tertiary Hospital in a Lower Economic Region of Ghana

Aidoo¹,

Mohammed²

2020

CAJPH

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There is dearth of data on the epidemiology of chronic liver diseases (CLDs) in northern Ghana. To this extent, we intended to investigate the distribution and determinants of the etiologies and complications of CLDs at the Tamale Teaching Hospital, a referral hospital of northern Ghana. The medical records of patients with CLDs admitted at the medical ward of Tamale Teaching Hospital from June to December 2019 were reviewed in a retrospective cross-sectional study. Out of 180 patients reviewed, 130 (72.2%) were males; the age range was 18-86 years, with a mean age of 41 43 years. Etiologies of CLDs comprised hepatis B viral infection (53.3%), hepatitis C viral infection (21.7%), unknown (9.4%), hepatocellular carcinoma (8.9%), and alcoholic liver disease (6.7%). Among the complications of CLDs; cirrhosis (71.1%), hypoalbuminemia (59.4%), ascites (58.3%) and jaundice (52.2%) occurred in more than half of the patients. Age (p=<0.001), education (p=0.005) and intake of herbal medicine (p=0.001) were associated with the etiologies of CLDs. There was a significant association between the etiologies of CLDs and complications; cirrhosis (p=<0.001), hypoalbuminemia (p=0.003), ascites (p=<0.001), and jaundice (p=0.009). Hepatitis B and hepatitis C viral infections were the main etiologies of CLDs. Young/middle age, noneducation and intake of herbal medicine were risk factors for the main etiologies of CLDs. Cirrhosis, hypoalbuminemia, ascites, and jaundice were the major complications of CLDs. Chronic hepatitis B and C viral infections were risk factors for developing the major complications of CLDs. Implementation of integrated public health strategies targeted at risk groups (young/middle age adults, illiterates, consumers of herbal medicine, patients with hepatitis B and C viral infections) may help curtail the burden of CLDs in northern Ghana.

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Predictive Factors in the Incidence of Cirrhosis in Chronic Hepatitis B Virus Infections

Abstract: Background: Hepatitis B virus (HBV) is among the leading causes of liver cirrhosis worldwide. Predictors of cirrhosis in Iranian chronic hepatitis B (CHB) patients are yet to be clearly identified.

Cited by 14 publications

References 44 publications

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection

The relationship between serum hepatitis B virus DNA level and liver histology in patients with chronic HBV infection

Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Distribution and Determinants of Etiologies and Complications of Chronic Liver Diseases Among Patients at a Tertiary Hospital in a Lower Economic Region of Ghana

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