Predictive factors for remission and death in 73 patients with autoimmune hepatitis in Japan

Development of Hepatocellular Carcinoma in a Woman with HBV- and HCV-negative Autoimmune Hepatitis with Unsatisfactory Response to Corticosteroid

“…Based on these findings, we consider that longterm continuous inflammation rather than existence of hepatitis C virus-RNA contributes to the development of hepatocellular carcinoma. In most of the patients with autoimmune hepatitis that developed hepatocellular carcinoma, the disease had already progressed to cirrhosis at the time of the diagnosis of hepatocellular carcinoma (4)(5)(6)(7)(8)(9)(10)(11)(12). In the present case, although hepatitis C virus-RNA was not tested in the liver tissue, serum anti-hepatitis C antibody and hepatitis C virus-RNA were negative, and alanine aminotransferase levels were persistently abnormal in spite of prednisolone treatment.…”

“…Several cases of hepatocellular carcinoma associated with autoimmune hepatitis in which hepatitis B virus and hepatitis C virus infections were absent have been reported in the English literature since the availability of hepatitis C virus testing (4)(5)(6)(7)(8)(9)(10)(11)(12). Hepatocellular carcinoma has been suggested to occur with long-standing cirrhosis; however, the mechanism by which hepatocellular carcinoma develops in autoimmune hepatitis remains unknown.…”

The aspartate aminotransferase-to-alanine aminotransferase ratio predicts all-cause and cardiovascular mortality in patients with type 2 diabetes

“…Moreover, when the AAR was modeled as categorical variable, a J shaped curve delineated the relationship between the AAR and mortality risk with patients with AAR >1 being at the highest risk of mortality. Although the relationship between serum transaminase levels and mortality has been extensively evaluated, [23] the AAR has been mainly used as a marker of the severity of chronic liver diseases, including alcoholic and non-alcoholic liver diseases and chronic viral hepatitis C, [ 24–30 ] but not of autoimmune hepatitis where the AAR was also associated with an increased risk of mortality [31] . As suggested by some studies, increasing AAR may be considered a reliable marker of the severity of liver fibrosis.…”

Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1

“…However, the responses to prednisolone (PSL) and azathioprine (AZA) therapies are favorable, and the long-term survival rate ranges from 80 to 90% or more [1][2][3]. On the other hand, we previously reported that factors involved in the poor prognosis of AIH included an unfavorable response to initial treatment and the presence of liver cirrhosis at the time of diagnosis [4]. According to studies regarding the appearance of hepatocellular carcinoma (HCC) in patients with AIH, the background has changed over time, although the incidence is low [5][6][7][8][9][10][11][12][13][14].…”