Predictive and prognostic value of FDG‐PET in nonsmall‐cell lung cancer

Geus‐Oei, Lioe‐Fee de; Heijden, Erik H F M van der; Corstens, F.H.M.; Oyen, Wim J.G.

doi:10.1002/cncr.22979

Cited by 141 publications

(97 citation statements)

References 81 publications

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“…Our data also showed that SUV max is positively correlated with OS, which is in agreement with previously reported data about the role of SUV max as a good predictor factor in NSCLC [31,32] .…”

Section: Discussionsupporting

confidence: 93%

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Said

Koshy

Rizk

et al. 2013

JBGC

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Background: Small cell lung carcinoma (SCLC) is one of the most aggressive solid tumors. The predictive and prognostic role of positron emission tomography (PET) scans in SCLC is under investigation and is yet to be determined. Method:We retrospectively analyzed the correlation between overall survival and 2-[18F]-fluoro-2-deoxy-d-glucose-PET (FDG-PET) results at diagnosis. We also introduced the concept of the total standardized uptake value (SUV) as a possible biomarker for the total burden disease. In addition, we proposed a new staging concept using PET scan based on whether tumor uptake is or is not limited to parenchymal hemithorax. Results:Between March 2004 and February 2009, 46 patients with histologically confirmed SCLC were included in the analysis. Thirty patients were found to have Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2, and most (65%, n = 30) of them had limited stage disease using conventional clinical staging criteria. There was a fair correlation between PET results and conventional staging by CT scan (kappa = 0.330). Although there was a trend toward upstaging by PET, it was not predictive of survival. There was a direct correlation between total SUV and maximum SUV and overall survival (hazard ratio [HR] = 1.003 and 1.085, respectively). Conclusion:PET scan results at diagnosis could play an important role in the management of SCLC. Total SUV could represent a good biomarker for the disease burden in SCLC. Further prospective studies are needed to clarify the application of total SUV in SCLC.

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Section: Discussionsupporting

confidence: 93%

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Said

Koshy

Rizk

et al. 2013

JBGC

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“…In a number of reports, 5 year survival rates for patients with stage I disease range 60~75 %, while for stage II disease five-year survival rates vary from 36~60 % [2-6]. However, the recurrence rate after curative resection still remains high and approximately half of the patients may relapse and die within 5 years, and majority of these relapses are due to distant metastasis and occur within 2 years after complete resection [7,8].Fluorine-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) has been established as a standard imaging technique in staging, treatment monitoring, prediction of survival after treatment, and follow-up of NSCLC patients [9][10][11][12][13][14][15]. Maximal standardized uptake value (SUV max ) measured by F-18 FDG PET is a semiquantitative index reflecting tumor metabolism and activities.…”

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confidence: 99%

“…Fluorine-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) has been established as a standard imaging technique in staging, treatment monitoring, prediction of survival after treatment, and follow-up of NSCLC patients [9][10][11][12][13][14][15]. Maximal standardized uptake value (SUV max ) measured by F-18 FDG PET is a semiquantitative index reflecting tumor metabolism and activities.…”

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confidence: 99%

Prediction of survival and cancer recurrence using F-18 FDG PET/CT in patients with surgically resected early stage (Stage I and II) non-small cell lung cancer

Kim

Kim²,

Kim³

et al. 2011

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The aim of the current study was to investigate the prognostic value of SUV max in patients with completely resected early stage (stage I & II) NSCLC.A retrospective review identified 76 patients with surgically resected early (stage I and II) NSCLC who received F-18 FDG PET/CT at diagnosis of cancer. Survival analysis was conducted using Kaplan-Meier analysis, and survival curves stratified by age, sex, mediastinal lymph node involvement, SUV max , and TNM staging were generated for estimation of overall survival and disease free survival (DFS). Independent predictive factors for survival were determined using Cox proportional hazard model.For overall survival, the median survival of the patients with tumor SUV max ≤6.7 was 48.9 months and was significantly longer than the patients with tumor SUV max >6.7 (Log rank test, Χ 2 =18.01, p<0.0001). The overall DFS was better in patients with tumor SUV max ≤5.9 than the patients with tumor SUV max >5.9. The median survival of the patients with tumor SUV max ≤5.9 was 31.7 months (Log rank test, Χ 2 =16, p=0.0001). In conclusion, high FDG uptake measured by F-18 FDG PET/CT might have a prognostic value for overall survival and DFS in surgically resected early stage (stage I & II) NSCLC even after stratified by pathologic stages. Traditionally, early stage non-small cell lung cancer (NSCLC) is managed with surgical resection. In contrast to locally advanced and metastatic NSCLC, the prognosis following resection for early stage disease is favorable. In a number of reports, 5 year survival rates for patients with stage I disease range 60~75 %, while for stage II disease five-year survival rates vary from 36~60 % [2-6]. However, the recurrence rate after curative resection still remains high and approximately half of the patients may relapse and die within 5 years, and majority of these relapses are due to distant metastasis and occur within 2 years after complete resection [7,8].Fluorine-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) has been established as a standard imaging technique in staging, treatment monitoring, prediction of survival after treatment, and follow-up of NSCLC patients [9][10][11][12][13][14][15]. Maximal standardized uptake value (SUV max ) measured by F-18 FDG PET is a semiquantitative index reflecting tumor metabolism and activities.Several previous studies suggested the prognostic role of F-18 FDG PET in patients with early stage NSCLC after complete resection [16][17][18][19][20]. Although different threshold SUV max values were proposed, high FDG uptake is associated with reduced overall survival and disease-free survival of patients with completely resected early stage NSCLC.In the current study, we investigated the prognostic value of SUV max measured by preoperative F-18 FDG PET in patients with completely resected early stage (stage I & II) NSCLC.

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“…Since metabolically active cells selectively take up and trap fluoridated glucose, the intensity of FDG uptake correlates with tumor growth rates and it has gained acceptance as a prognostic marker in patients with NSCLC and provides prognostic information beyond that of TNM staging alone. [12][13][14] Several studies demonstrated that the maximal standardized uptake (SUVmax) measurement on 18F-FDG-PET is related with expression levels of some biomarkers, such as Glut 1 and vascular endothelial growth factor (VEGF). 15,16 However, there are few studies investigating the correlation between 18F-FDG uptake and ERCC1 expression in NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Role of ERCC1 Protein Expression and its Correlation with 18F-FDG Uptake on PET in Patients with Resected Non-Small Cell Lung Cancer

Kumbasar¹

2017

UHOD

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ERCC1 is a protein which is found to be associated with resistance to platinum-based chemotherapy. FDG uptake is considered as a prognostic marker in patients with NSCLC and provides information beyond that of TNM staging. The aim of this study is to examine both prognostic values of ERCC1 expression and 18F-FDG uptake on PET and their relationship in patients who underwent pulmonary resection for NSCLC. Although high expression of ERCC1 was found to be associated with better survival, the difference was not considered as statistically significant (p= 0.067). There is a significant survival advantage in ERCC1 (+) patients who did not receive adjuvant therapy (p= 0.047). High maximal standard uptake value (SUVmax) was found to be associated with poor survival (hazard ratio [HR]: 1.10; 95% CI, 1.02-1.18; p= 0.009). Correlation between ERCC1 expression and mean SUVmax was statistically insignificant (p= 0.915). Among patients with SUVmax ≥2.5, ERCC1 positivity was 57.4% in patients who survived and 29.4% in patients who died which was statistically significant (p= 0.048). The association between high 18F-FDG uptake on PET and poor outcome was confirmed, but we failed to detect a powerful correlation between ERCC1 expression and SUVmax. Keywords: ERCC1, Survival, Positron emission tomography ÖZET Küçük Hücreli Dışı Akciğer Kanseri'nde ERCC1'in Prognostic Rolü ve 18F-FDG Tutulumu ile KorelasyonuERCC1 protein pozitifliği ile platin bazlı kemoterapi arasında direnç olduğu bulunmuştur. FDG tutulumunun ise KHDAK'da prognostik bir belirteç olduğu, TNM sınıflamasının ötesinde prognostik bilgi verdiği kabul edilmektedir. Bu çalışmanın amacı, KHDAK nedeniyle akciğer rezeksiyonu uy-gulanmış olan hastalarda hem ERCC1 proteininin prognostik değerinin hem de ERCC1 ekspresyonunun PET'te 18F-FDG tutulumu ile olan korelasyonunu araştırılmasıdır. KHDAK tanısıyla PET sonrası akciğer rezeksiyonu uygulanmış olan 71 hasta retrospektif olarak incelendi. ERCC1 ekspresyonu olan hastaların sağkalımı istatistiksel olarak anlamlı olmasa da daha iyi bulundu (p= 0.067). Adjuvan tedavi almayan hastalarda ERCC1 pozitif hastalarda anlamlı sağkalım avantajı olduğu görüldü (p= 0.047). Yüksek SUVmax değerleri kötü prognozu gösterdi (hazard ratio [HR]: 1.10; 95% CI, 1.02-1.18; p= 0.009). ERCC1 ekspresyonu ile ortalama SUVmax değerleri arasında anamlı korelasyon saptanmadı (p= 0.915). SUVmax ≥2.5 olan hastalarda, ölen hastalarda ERCC1 pozitifliği %57.4, yaşayan hastalarda %29.4 olarak saptandı (p= 0.048). Yüksek 18F-FDG tutulumu değerleri ile kötü prognoz ilişkisi bu çalışma ile tekrar gösterilmiş oldu. Ancak, ERCC1 ekspresyonu ile SUVmax değerleri arasında güçlü bir korelasyon saptanamadı.

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Predictive and prognostic value of FDG‐PET in nonsmall‐cell lung cancer

Cited by 141 publications

References 81 publications

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Prediction of survival and cancer recurrence using F-18 FDG PET/CT in patients with surgically resected early stage (Stage I and II) non-small cell lung cancer

Prognostic Role of ERCC1 Protein Expression and its Correlation with 18F-FDG Uptake on PET in Patients with Resected Non-Small Cell Lung Cancer

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Predictive and prognostic value of FDG‐PET in nonsmall‐cell lung cancer

Cited by 141 publications

References 81 publications

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Prognostic value of FDG-PET scans at diagnosis in small cell lung cancer

Prediction of survival and cancer recurrence using F-18 FDG PET/CT in patients with surgically resected early stage (Stage I and II) non-small cell lung cancer

Prognostic Role of ERCC1 Protein Expression and its Correlation with 18F-FDG Uptake on PET in Patients with Resected Non-Small Cell Lung Cancer

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Prognostic Role of ERCC1 Protein Expression and its Correlation with 18F-FDG Uptake on PET in Patients with Resected Non-Small Cell Lung Cancer