Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis

Li, Yuqiang; Zhou, Zhongyi; Li, Da; Zhou, Ming; Tan, Fengbo; Liu, Wenxue; Zhu, Hong

doi:10.1155/2020/6131485

Cited by 7 publications

(5 citation statements)

References 32 publications

(13 reference statements)

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“…Radical surgery including lymphadenectomy of CRC is a decisive factor for prognosis and is necessary for the therapeutic staging of the patient, the minimum number of 12 examined lymph nodes has been accepted in clinics since 1990 31 . We found that the identification of fewer than 12 regional nodes was associated with a worse CSS, which was consistent with many studies 20 , 32 . In particular, the role of primary tumor resection in CRC patients with distant metastases remains controversial.…”

Section: Discussionsupporting

confidence: 92%

Nomograms predicting cancer-specific survival for stage IV colorectal cancer with synchronous lung metastases

Cheng

Chen

Huang

et al. 2022

Sci Rep

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This study aimed to establish a nomogram for the prediction of cancer-specific survival (CSS) of CRC patients with synchronous LM. The final prognostic nomogram based on prognostic factors was evaluated by concordance index (C-index), time-dependent receiver operating characteristic curves, and calibration curves. In the training and validation groups, the C-index for the nomogram was 0.648 and 0.638, and the AUC was 0.793 and 0.785, respectively. The high quality of the calibration curves in the nomogram models for CSS at 1-, 3-, and 5-year was observed. The nomogram model provided a conventional and useful tool to evaluate the 1-, 3-, and 5-year CSS of CRC patients with synchronous LM.

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Section: Discussionsupporting

confidence: 92%

Nomograms predicting cancer-specific survival for stage IV colorectal cancer with synchronous lung metastases

Cheng

Chen

Huang

et al. 2022

Sci Rep

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“…Our previous research explored the prognostic factors of colorectal liver-limited and lung-limited metastasis, that were inconsistent between the two groups [24,25]. Similarly, T staging can be used as a prognostic factor for rectal lung-limited metastasis but not for rectal liver-limited metastasis in this study (Table S3).…”

Section: Discussionmentioning

confidence: 85%

The survival impact of radiotherapy on synchronous metastatic rectal cancer: metastatic site can serve for radiotherapy-decision

Zhou¹,

Wang²,

Tan³

et al. 2022

J. Cancer

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Purpose: The metastatic site seems to represent a malignancy with a different biological characteristic. Radiotherapy, as a successful, well-tolerated, cost-effective and time-efficient intervention, is able to provide clear benefits for the treatment of locally advanced rectal cancer and has become an essential component of palliative oncology care. The real-world effect of radiotherapy on the survival outcomes of metastatic rectal cancer (mRC) patients might do exist and was worth exploring. Patients and methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database in this retrospective analysis. The statistical methods included Pearson's chi-square test, Log-rank test, Cox regression model and propensity score matching (PSM). Results: The multivariable Cox regression displayed that radiotherapy may not be used as a prognostic factor for mRC (p=0.057). However, radiotherapy may be associated with the prognosis if the metastatic site was excluded from the multivariate analysis (p<0.001). Radiotherapy seemed to fail to improve OS before PSM (p<0.001) and after PSM without the metastatic site as a matching factor (p<0.001). Nevertheless, there was no significant survival difference between radiotherapy and non-radiotherapy cohort after PSM with the metastatic site as a matching factor (p=0.057). All of M1a rectal cancer patients appear to obtain survival benefit from radiotherapy without the impact of PSM (p<0.001). Notwithstanding, radiotherapy was associated with improved OS of patients with rectal liver-limited metastasis (p=0.023) and did not appear to provide survival benefit for rectal lung-limited (p=0.386) and other-limited metastasis (p=0.385). Both of M1b mRC with and without liver metastasis did not seem to obtain survival benefit from radiotherapy. Conclusions: Carefully selected data from the SEER database suggested that radiotherapy appears to improve overall survival only in patients with rectal liver-limited metastasis.

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“…Approximately 60% of OC patients were determined at an advanced stage. Previous studies reported that the invasion of OC cells mainly depends on the hematogenous circulation and lymphatic channels [2], and pulmonary metastases in OC always are classified at a lower-level outcome that notably leads to a poor prognosis [3,4]. As the second most common distant metastatic site, the morbidity of lung metastasis (LM) ranges from 6% to 16% [5][6][7][8].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

Qian¹,

Chen²,

Peng³

et al. 2023

J. Cancer

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Objective:The study aimed to evaluate the risk factors for the morbidity and prognosis of lung metastases (LM) in patients with newly diagnosed ovarian cancer (OC), and further explore the important role of marital status. Materials and methods: Based on the Surveillance, Epidemiology, and End Results (SEER) dataset, OC patients from 2010 and 2019 were retrospectively analyzed. Logistic regression analysis and Kaplan-Meier method were applied to evaluate the vital factors of incidence and survival outcome in LM population. Cox regression analysis was performed to identify risk factors for the prognosis of OC patients with LM. The predictive potential was showed by two established nomograms and examined by the concordance index (C-index), calibration curves, the area under the curve (AUC), decision curve analyses (DCAs) and clinical impact curves (CICs). Results: There are 25,202 eligible OC patients were enrolled in the study, the morbidity of LM at 5.61%. Multivariable logistic regression models illustrated that chemotherapy (P<0.01), surgical treatment of bilateral or more areas (P<0.01), T stage (P<0.01), N1 stage (P<0.01), bone metastasis (P<0.01), brain metastasis (P<0.01) and liver metastasis (P<0.01) were all significantly connected with LM in OC. Multivariable Cox regression analyses illustrated that unmarried, radiotherapy, elder people and positive cancer antigen 125 (CA-125) were significantly associated with shorter survival time, while chemotherapy made contributions to improve survival. Our study found that marital relationships promoted LM and was associated with the better prognosis, while unmarried patients had the opposite results. With the further development of our research, the cross-action of social, economic and psychological factors together determined the great impact of marital status on the morbidity and prognosis of OC patients combined with LM. Finally, the stability of the models was proved by internal verification. Conclusion:The population-based cohort study provides references for guiding clinical screening and individualized treatment of OC patients with LM. Under the influence of society and economy, marital status is closely related to the morbidity and prognosis of OC, which can be an important direction to explore the risk of OC lung metastasis in the future.

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Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis

Cited by 7 publications

References 32 publications

Nomograms predicting cancer-specific survival for stage IV colorectal cancer with synchronous lung metastases

Nomograms predicting cancer-specific survival for stage IV colorectal cancer with synchronous lung metastases

The survival impact of radiotherapy on synchronous metastatic rectal cancer: metastatic site can serve for radiotherapy-decision

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

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