Prediction of treatment response in head and neck carcinomas using IVIM-DWI: Evaluation of lymph node metastasis

Hauser, Thomas; Essig, Marco; Jensen, Alexandra; Laun, Frederik Bernd; Münter, Marc W.; Maier‐Hein, Klaus H.; Stieltjes, Bram

doi:10.1016/j.ejrad.2014.02.013

Cited by 73 publications

(74 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ADC incorporates the effects of both perfusion and diffusion, whereas D is associated to molecular diffusion. Our findings regarding the D and f values are consistent with previous studies 18, 19. Kim et al found that the median nodal tumor volume of the PR group was higher, but not significantly different from that of the CR group 11.…”

Section: Discussionsupporting

confidence: 93%

“…Hauser et al reported in a 15 patient feasibility study that pre‐TX D values were not significantly different, while f was significantly higher in patients with local regional failure compared with those with local regional control 19. While Ding et al recently reported in an IVIM DW‐MRI study with 31 HNSCC patients that mid‐TX values for ADC, D, and f were significantly higher than the pre‐TX values for all lesions 18.…”

Section: Discussionmentioning

confidence: 96%

“…The quantitative imaging metrics, derived from IVIM, are the diffusion coefficient (D), perfusion fraction (f) and pseudo‐diffusion coefficient (D*), measured without the use of a contrast agent 16, 17. Recently, feasibility studies have shown the utility of IVIM DW‐MRI in the characterization of HNSCC 18, 19, 20, 21…”

mentioning

confidence: 99%

See 2 more Smart Citations

Intravoxel incoherent motion diffusion‐weighted MRI during chemoradiation therapy to characterize and monitor treatment response in human papillomavirus head and neck squamous cell carcinoma

Paudyal

Riaz

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

PurposeCharacterize and monitor treatment response in human papillomavirus (HPV) head and neck squamous cell carcinoma (HNSCC) using intra‐treatment (intra‐TX) imaging metrics derived from intravoxel incoherent motion (IVIM) diffusion‐weighted magnetic resonance imaging (DW‐MRI).Materials and MethodsThirty‐four (30 HPV positive [+] and 4 HPV negative [‐]) HNSCC patients underwent a total of 136 MRI including multi‐b value DW‐MRI (pretreatment [pre‐TX] and intra‐TX weeks 1, 2, and 3) at 3.0 Tesla. All patients were treated with chemo‐radiation therapy. Monoexponential (yielding apparent diffusion coefficient [ADC]) and bi‐exponential (yielding perfusion fraction [f], diffusion [D], and pseudo‐diffusion [D*] coefficients) fits were performed on a region of interest and voxel‐by‐voxel basis, on metastatic neck nodes. Response was assessed using RECISTv1.1. The relative percentage change in D, f, and D* between the pre‐ and intra‐TX weeks were used for hierarchical clustering. A Wilcoxon rank‐sum test was performed to assess the difference in metrics within and between the complete response (CR) and non‐CR groups.ResultsThe delta (Δ) change in volume (V)1wk‐0wk for the CR group differed significantly (P = 0.016) from the non‐CR group, while not for V2wk‐0wk and V3wk‐0wk (P > 0.05). The mean increase in ΔD3wk‐0wk for the CR group was significantly higher (P = 0.017) than the non‐CR group. ADC and D showed an increasing trend at each intra‐TX week when compared with pre‐TX in CR group (P < 0.003). Hierarchical clustering demonstrated the existence of clusters in HPV + patients.ConclusionAfter appropriate validation in a larger population, these IVIM imaging metrics may be useful for individualized treatment in HNSCC patients. Level of Evidence: 2J. Magn. Reson. Imaging 2017;45:1013–1023

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Intravoxel incoherent motion diffusion‐weighted MRI during chemoradiation therapy to characterize and monitor treatment response in human papillomavirus head and neck squamous cell carcinoma

Paudyal

Riaz

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…The efficacy of f in the prediction of treatment response to chemoradiotherapy has been investigated for HNSCC [16]. In previous studies, the range of f values assessed using the IVIM model for metastatic neck nodes was 13-42% [17,18]; however, the f value in the present study was relatively low in both groups.…”

Section: Resultsmentioning

confidence: 56%

The Role of Intravoxel Incoherent Motion MRI in Predicting Early Treatment Response to Chemoradiation for Metastatic Lymph Nodes in Nasopharyngeal Carcinoma

2016

Adv Ther

View full text Add to dashboard Cite

show abstract

“…Hauser et al 31,32 suggested that a high initial f for primary cancer may predict poor treatment response to CRT in patients with HNSCC. On the contrary, by using DCE-MRI, Chawla et al 33 reported that tumor with a lower plasma volume fraction (PV) may predict a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Intra-Voxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) in Predicting Induction Chemotherapy Response in Locally Advanced Hypopharyngeal Carcinoma

Guo

Luo²,

Meng³

et al. 2016

Medicine

View full text Add to dashboard Cite

The aim of this study was to predict response to induction chemotherapy in patients with locally advanced hypopharyngeal carcinoma by IVIM values.Twenty-eight patients with locally advanced hypopharyngeal carcinoma underwent IVIM studies using 12 different b values (b = 0, 10, 20, 30, 50, 70 100, 150, 200, 400, 800, and 1000 s/ mm2). All patients underwent 2 MRI studies: a baseline exam before any treatment and a mid-treatment exam 3 weeks after induction chemotherapy. In the IVIM approach, D∗, f, and D were extracted from a bi-exponential fit. For comparison, the ADC map were extracted from a mono-exponential fit. At the end of induction chemotherapy, patients were classified as responders or nonresponders group according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST), based on their MRI measurement. The patients were classified into high grade group (G1), moderate grade group (G2), and low grade group (G3) according to the tumor pathological grading. The predictive value of IVIM parameters were examined with Student's t test, analysis of variance (ANOVA), and receiver operating characteristic (ROC) curves.After 2 cycles of induction chemotherapy, 18 patients were categorized into the responder group whereas the other 10 patients were considered nonresponders. Compared with the pretreatment value, the post-treatment ADC value and D value was significantly higher and the posttreatment D∗ value was significantly lower (all P < 0.05). In contrast, post-treatment f parameter only changed slightly (P > 0.05). Compared with nonresponders, a notably lower pretreatment ADC value, D value, posttreatment D∗ value, and higher posttreatment ADC value, D value, ΔADC, ΔD, and ΔD∗ were observed in responders (all P < 0.05), but no significant change in Δ f among the 2 group (P > 0.05). The ROC curve analysis indicated that the cutoff of pretreatment D value in best predicting tumor's chemotherapeutic response was 0.847 × 10−3 mm2/s, and the corresponding AUC, sensitivity, and specificity were 0.806, 75.0%, and 88.9%, respectively. Although pretreatment IVIM-derived parameters had no significant differences between high grade, moderate grade, and low grade group, a trend towards lower D∗ was observed with increasing tumor grading from G3 to G1.IVIM-DWI can potentially predict the treatment response to induction chemotherapy for hypopharyngeal carcinoma.

show abstract

Prediction of treatment response in head and neck carcinomas using IVIM-DWI: Evaluation of lymph node metastasis

Cited by 73 publications

References 25 publications

Intravoxel incoherent motion diffusion‐weighted MRI during chemoradiation therapy to characterize and monitor treatment response in human papillomavirus head and neck squamous cell carcinoma

Intravoxel incoherent motion diffusion‐weighted MRI during chemoradiation therapy to characterize and monitor treatment response in human papillomavirus head and neck squamous cell carcinoma

The Role of Intravoxel Incoherent Motion MRI in Predicting Early Treatment Response to Chemoradiation for Metastatic Lymph Nodes in Nasopharyngeal Carcinoma

Pretreatment Intra-Voxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) in Predicting Induction Chemotherapy Response in Locally Advanced Hypopharyngeal Carcinoma

Contact Info

Product

Resources

About