Prediction of the therapeutic mechanism responsible for the effects of Sophora japonica flower buds on contact dermatitis by network-based pharmacological analysis

Kim, Youn Sook; Oh, Yoona; Lee, Hongbum; Yang, Beodeul; Choi, Chan-Hun; Jeong, Hyun‐Woo; Kim, Hyungwoo; An, Won-Gun

doi:10.1016/j.jep.2021.113843

Cited by 8 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports revealed the important contribution of major constituents of G. glabra , glycyrrhetinic acid, glycyrrhizin, glabridin, isoliquiritigenin, licochalcone A and liquiritin, in the management of skin conditions, owing to their notable antimicrobial, antioxidant and anti-inflammatory effects [ 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. In addition, the flavonoids of S. japonica are reported for their antioxidant, antimicrobial and anti-inflammatory properties [ 63 ], besides their role in skin conditions as contact dermatitis [ 14 , 64 ]. It has been shown that sophoraflavanone G has various activities, including being antimicrobial, antioxidant and anti-inflammatory, along with a limited cytotoxicity, valuable for wound healing [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

et al. 2023

View full text Add to dashboard Cite

Glycyrrhiza glabra and Sophora japonica (Fabaceae) are well-known medicinal plants with valuable secondary metabolites and pharmacological properties. The flavonoid-rich fractions of G. glabra roots and S. japonica leaves were prepared using Diaion column chromatography, and the confirmation of flavonoid richness was confirmed using UPLC-ESI-MS profiling and total phenolics and flavonoids assays. UPLC-ESI-MS profiling of the flavonoid-rich fraction of G. glabra roots and S. japonica leaves resulted in the tentative identification of 32 and 23 compounds, respectively. Additionally, the wound healing potential of topical preparations of each fraction, individually and in combination (1:1) ointment and gel preparations, were investigated in vivo, supported by histopathological examinations and biomarker evaluations, as well as molecular docking studies for the major constituents. The topical application of G. glabra ointment and gel, S. japonica ointment and gel and combination preparations significantly increase the wound healing rate and the reduction of oxidative stress in the wound area via MDA reduction and the elevation of reduced GSH and SOD levels as compared to the wound and Nolaver®-treated groups. The molecular docking study revealed that that major compounds in G. glabra and S. japonica can efficiently bind to the active sites of three proteins related to wound healing: glycogen synthase kinase 3-β (GSK3-β), matrix metalloproteinases-8 (MMP-8) and nitric oxide synthase (iNOS). Consequently, G. glabra roots and S. japonica leaves may be a rich source of bioactive metabolites with antioxidant, anti-inflammatory and wound healing properties.

show abstract

Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Generally, when the drug OB value is greater than or equal to 30%, it indicates that the oral bioavailability is good and it is easy for the body to absorb and play a role (Kim et al. 2021 ). The value of DL reflects the possibility of the compound becoming a drug.…”

Section: Discussionmentioning

confidence: 99%

“…When DL is greater than or equal to 0.18, it is showed that the compound has the higher drug-like property and possibility of becoming a drug (Kim et al. 2021 ). In this paper, 18 underlying effective components of SD were screened using TCMSP database according to OB ≥ 30% and DL ≥ 0.18.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Wang

et al. 2022

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Saposhnikovia divaricata (Turcz.) Schischk (Apiaceae) (SD) has various pharmacological activities, but its effects on type I allergy (TIA) have not been comprehensively studied. Objective This study evaluates the treatment and molecular mechanisms of SD against TIA. Materials and methods The effective components and action targets of SD were screened using TCMSP database, and allergy-related targets of SD were predicted using GeneCards and OMIM database. The obtained target intersections were imported into David database for GO analysis, and used R software to perform KEGG analysis. The RBL-2H3 cells sensitised by DNP-IgE/DNP-BSA were treated with different concentrations of SD (root decoction, 0.5, 1, and 2 mg/mL), prim- O -glucosylcimifugin (POG, 10, 40, and 80 μg/mL) and the positive control drug–ketotifen fumarate (KF, 30 μM) for 12 h, then subjected to cell degranulation and qPCR analysis. Results Eighteen active compounds of SD and 38 intersection targets were obtained: TIA-related signal pathways mainly include calcium signal pathway, PI3K–Akt signal pathway and MAPK signal pathway. Taking the β-Hex release rate of the model group as the base, the release rate of SD and POG in high dose groups were 43.79% and 57.01%, respectively, which were significantly lower than model group ( p < 0.01), and significantly lower than KF group (63.83%, p < 0.01, p < 0.05). SD and POG could down-regulate the expression of related proteins in the Lyn/Syk, PI3K/AKT and MAPK signalling pathways. Discussion and conclusion Saposhnikovia divaricata could inhibit IgE-induced degranulation of mast cells, providing a scientific basis for further research and clinical applications of SD in TIA treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Recently the flower buds of S. japonica have been used as cosmetic whitening agent (Kim et al 2021 ). The flower buds of S. japonica , which are a major traditional medicine in many Asian countries, are used to stop bleeding (Kim et al 2021 ), and therefore, they are used to treat bleeding haemorrhoids, hypertension, and pyoderma. Meanwhile, S. japonica L. was used as a haemostatic agent to treat hemorrhoids and hematemesis (Aly et al 2019 ; Elberry et al 2020 ), where S. viciifolia roots were utilized as a Chinese drug to treat fever, cystitis, haematuria, and edema (Ao et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

2021

View full text Add to dashboard Cite

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compounds from Sophora have been identified to possess several health-promising effects including anti-inflammatory, anti-arthritic, antiplatelets, antipyretic, anticancer, antiviral, antimicrobial, antioxidant, anti-osteoporosis, anti-ulcerative colitis, antidiabetic, anti-obesity, antidiarrheal, and insecticidal activities. Herein, the present review aims to provide comprehensive details about the phytochemicals and biological effects of Sophora species. The review spotlighted on the promising phytonutrients extracted from Sophora and their plethora of bioactivities. The review also clarifies the remaining gaps and thus qualifies and supplies a platform for further investigations of these compounds.

show abstract

Prediction of the therapeutic mechanism responsible for the effects of Sophora japonica flower buds on contact dermatitis by network-based pharmacological analysis

Cited by 8 publications

References 29 publications

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

Contact Info

Product

Resources

About