Prediction of Simultaneous Esophageal Lesions in Head and Neck Squamous Cell Carcinoma

Chow, Tam‐Lin; Lee, Daniel Tai-Yam; Choi, Chi‐Yee; Chan, Terrence; Lam, Siu-Ho

doi:10.1001/archoto.2009.105

Cited by 31 publications

(25 citation statements)

References 10 publications

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“…With the development of ESD for early esophageal neoplasm, it has become more important to define high‐risk groups and to perform screening endoscopy to detect early ESCN. The location of the index tumor was regarded as risk factor based on previous results, and hypopharyngeal cancer has been associated with a significantly higher frequency of ESCN than other locations of HNSCC . This finding might be a consequence of the neighboring location of the hypopharynx and esophagus, and could occur in part because of the pooling of saliva in the pyriform sinus .…”

Section: Discussionmentioning

confidence: 99%

“…NBI is a useful and noninvasive tool for detecting ESCN, with benefits of enhanced visualization of intrapapillary capillary loop patterns . LCE can be used to detect dysplastic lesions that go unnoticed with conventional WLE, which could alter the treatment plan for some patients . In addition, multiple Lugol‐voiding lesions are known to be associated with an increased risk of developing multiple cancers in the esophagus or the head and neck region .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is important to define the high‐risk groups and perform screening endoscopy in selected patients to detect early ESCN. The risk of developing synchronous and metachronous esophageal cancer associated with HNSCC is high, and the incidence of synchronous ESCN ranges from 1.0% to 21.9% . Previously, we investigated the prevalence and risk factors for the development of synchronous and metachronous ESCN in patients with HNSCC .…”

Section: Introductionmentioning

confidence: 99%

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Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Gong

Kim

et al. 2015

Dis Esophagus

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Early detection of synchronous esophageal squamous cell neoplasm (ESCN) in head and neck squamous cell carcinoma (HNSCC) patients can significantly affect their prognosis. We investigated the prevalence of synchronous ESCN and the risk factors for developing ESCN in patients with HNSCC, and evaluated the effect of routine endoscopic screening in these patients. Subjects who were diagnosed as HNSCC from May 2010 to January 2014 were eligible. All patients underwent conventional white light endoscopic examinations with narrow band imaging and Lugol chromoendoscopy. Among 458 subjects screened, 28 synchronous ESCN were detected in 24 patients (5.2%). The prevalence of ESCN was greatest in patients with hypopharyngeal cancer (20.9%). In multivariate analysis, pyriform sinus involvement was independent risk factor for developing synchronous ESCN (odds ratio 171.2, P < 0.001). During the follow-up period (median, 24 months), the 3-year overall survival rates was significantly lower in patients with ESCN than in patients without ESCN (54.2% vs. 78.3%, P = 0.0013). Routine endoscopic screening for detecting synchronous ESCN should be recommended for patients with HNSCC, especially those with pyriform sinus involvement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Gong

Kim

et al. 2015

Dis Esophagus

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“…Although previous studies have found certain risk factors for synchronous esophageal neoplasia in H&N cancer patients [12,13], there was no prospective study using routine application of NBI-ME and Lugol’s chromoendoscopy screening with standardized pathological classification. The aim of this prospective study was to determine the prevalence and risk factors for synchronous esophageal neoplasia and the impact of routine IEE screening on the decision making for the management of newly diagnosed H&N cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Chung

Liao

et al. 2013

BMC Gastroenterol

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BackgroundThe prevalence of esophageal neoplasia in head and neck (H&N) cancer patients is not low; however, routine esophageal surveillance is not included in staging of newly-diagnosed H&N cancers. We aimed to investigate the risk factors for synchronous esophageal neoplasia and the impact of endoscopy on management of H&N cancer patients.MethodsA total of 129 newly diagnosed H&N cancer patients who underwent endoscopy with white-light imaging, narrow-band imaging (NBI) with magnifying endoscopy (ME), and chromoendoscopy with 1.5% Lugol’s solution, before definite treatment were enrolled prospectively.Results60 esophageal lesions were biopsied from 53 (41.1%) patients, including 11 low-grade, 14 high-grade intraepithelial neoplasia and 12 invasive carcinoma in 30 (23.3%) patients. Alcohol consumption [odds ratio (OR) 5.90, 95% confidence interval (CI) 1.23-26.44], advanced stage (stage III and IV) of index H&N cancers (OR 2.98, 95% CI 1.11-7.99), and lower body mass index (BMI) (every 1-kg/m2 increment with OR 0.87, 95% CI 0.76-0.99) were independent risk factors for synchronous esophageal neoplasia. NBI with ME was the ideal screening tool (sensitivity, specificity, and accuracy of 97.3%, 94.1%, and 96.3%, respectively, for detection of dysplastic and cancerous esophageal lesions). The treatment strategy was modified after endoscopy in 20 (15.5%) patients. The number needed to screen was 6.45 (95% CI 4.60-10.90).ConclusionsNBI-ME surveillance of esophagus should be done in newly-diagnosed H&N cancer patients, especially those with alcohol drinking, lower BMI, and advanced stage of primary tumor.

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“…Several studies provide evidence for this result. 1,3,[20][21][22][23] The previous prospective study reported that the rate of second esophageal primary tumors was 1.9% in the 268 HNSCC patients. 23 One recent study reported that esophageal surveillance was recommended because early detection of esophageal cancer in HNSCC patients led to a good prognosis.…”

Section: 허경미 등 두경부 암 환자에서 수술 전 위장내시경mentioning

confidence: 99%

Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

허경미

김미희

김진환

et al. 2016

Korean J Gastroenterol

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Background/Aims: In head and neck squamous cell carcinoma, second primary gastrointestinal tumors are not uncommon. However, it is unclear whether a screening endoscopy is needed for detecting gastrointestinal neoplasm in patients with head and neck cancer. Therefore, we analyzed the prevalence and independent risk factors for second primary gastrointestinal neoplasm in head and neck squamous cell carcinoma. Methods: A consecutive series of 328 patients with primary head and neck squamous cell carcinoma that underwent esophagogastroduodenoscopy or colonoscopy were included using our registry. An age-and sex-matched group of 328 control subjects was enrolled. We assessed risk factors of synchronous gastrointestinal cancer. Results: The prevalence of esophageal cancer with head and neck squamous cell carcinoma was significantly higher than that of the control group (1.5% vs. 0.0%, p=0.011). An age of 54 years or more (OR, 1.033; 95% CI, 1.008-1.059; p=0.009) and male gender (OR, 4.974; 95% CI, 1.648-15.013; p=0.004) were risk factors for concomitant colorectal cancer or adenomas in the head and neck squamous cell carcinoma patients. Conclusions: Preoperative colonoscopy can be recommended for detecting synchronous second primary colorectal lesions in head and neck squamous cell carcinoma patients with male sex regardless of age, and esophagogastroduodenoscopy is necessary in all head and neck squamous cell carcinoma patients for detecting esophageal cancer. (Korean J Gastroenterol 2016;68:23-28)

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Prediction of Simultaneous Esophageal Lesions in Head and Neck Squamous Cell Carcinoma

Cited by 31 publications

References 10 publications

Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study

Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Is a Preoperative Gastrointestinal Endoscopy for Second Primary Cancer Detection in Head and Neck Cancer Necessary? Ten-year Registry Data

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