Prediction of Sentinel Lymph Node Micrometastasis by Histological Features in Primary Cutaneous Malignant Melanoma

Mraz-Gernhard, Serena; Sagebiel, Richard W.; Kashani‐Sabet, Mohammed; Miller, James R.; Leong, Stanley P. L.

doi:10.1001/archderm.134.8.983

Cited by 106 publications

(82 citation statements)

References 32 publications

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“…Angiolymphatic invasion has been reported as an adverse indicator for both SLN positivity and overall survival in patients with melanoma. 7,8,25,26 Body site location also was a significant predictor of SLN positivity in our model. Location of the primary melanoma on the trunk or lower extremities doubled the odds of SLN positivity (OR, 1.92) compared with location on the head/neck or upper extremities.…”

Section: Discussionmentioning

confidence: 70%

“…2,3 Other factors that have been examined variably include patient age, anatomic location, mitotic rate, ulceration, angiolymphatic invasion, lymphangiogenesis, Clark level, vertical growth phase, tumor-infiltrating lymphocytes, regression, and satellitosis. [5][6][7][8][9][10] Differences in study design and data collected no doubt explain some of the variation in factors that reportedly are associated significantly with positive SLN status.…”

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confidence: 99%

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The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

175

106

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Epithelial growth, branching, and canalization are important morphogenetic events of the rodent ventral prostate (VP) that take place during the first postnatal week. In this study, we evaluated the effect of knocking out MMP‐2 (MMP‐2−/−), by examining developmental and structural aspects of the VP in MMP‐2−/− mice. Neonate (day 6) MMP‐2−/− mice showed fewer epithelial tips, a lower epithelial cell proliferation rate, and also reticulin fiber accumulation. The VP of adult MMP‐2−/− mice showed lower relative weight, smaller epithelial and smooth‐muscle cell volume, and a larger amount of thicker reticulin fibers. No differences in cell proliferation or apoptotic index were noted between adult MMP‐2−/− and wild‐type mice. MMP‐9 was found in the adult MMP‐2−/−, but not in the wild‐type. In conclusion, MMP‐2 function is essential for the epithelial morphogenesis of the mouse VP, and expression of MMP‐9 is not sufficient for acquisition of the normal adult histology. Developmental Dynamics 239:2386–2392, 2010. © 2010 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Paek

Griffith

Johnson

et al. 2006

Cancer

175

106

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“…Clinical adverse factors include increasing age, male, location of the lesion, and metastasis. Moreover, regional lymph node (Sentinel) status has emerged as an accurate method for evaluating the draining lymph node basin, allowing for the generation of valuable prognostic information (Mraz-Gernhard et al, 1998). Sentinel lymph node biopsy became a compulsory phase for patients with tumour thickness > 1 mm (Patnana, et al, 2011;Petrescu, et al, 2010).…”

Section: Routine Diagnostic Methods and Prognostic Factorsmentioning

confidence: 99%

Differential Scanning Calorimetry, as a New Method to Monitor Human Plasma in Melanoma Patients with Regional Lymph Node or Distal Metastases

Ferencz¹,

Fekecs²,

Lőrinczy³

2011

Skin Cancer Overview

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“…Some studies have correlated the frequency of angiolymphatic invasion with increasing depth and level of tumor invasion, 59 while others have shown vascular invasion to be a significant predictor of metastasis 90 or of reduced survival. 11 It is perhaps the low frequency of this finding that prevented its emergence as an independent prognostic variable in many earlier series, but more recent data has shown a reduced survivorship of some 40% over 8 years when angioinvasion is demonstrated in primary tumors in vertical growth phase.…”

Section: Blood Vessel and Lymphatic Invasionmentioning

confidence: 99%

Prognosticators of melanoma, the melanoma report, and the sentinel lymph node

2006

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Since the 1960s, the clinical characteristics of melanoma, its histopathology and its biological basis have been the subject of intense study at pigmented lesion clinics in North America, Europe, and Australia. More recently, the immense database of the Melanoma Committee of the American Joint Committee on Cancer (AJCC) has been exploited through complex mathematical models to measure the impact of various histologic features of primary melanomas and of sentinel lymph node deposits and to correlate these parameters with patient survival. The wealth of modern information available to pathologists and clinicians has become of vital interest to the prognostication of the individual patient with melanoma. The purpose of this review is to bring to the attention of anatomic pathologists the essential characteristics of the pathology report for primary cutaneous melanoma in the modern era.

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Prediction of Sentinel Lymph Node Micrometastasis by Histological Features in Primary Cutaneous Malignant Melanoma

Cited by 106 publications

References 32 publications

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma

Differential Scanning Calorimetry, as a New Method to Monitor Human Plasma in Melanoma Patients with Regional Lymph Node or Distal Metastases

Prognosticators of melanoma, the melanoma report, and the sentinel lymph node

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