Prediction of Relapse in Schizophrenic Outpatients Treated by Drug and Sociotherapy

Catastrophe Theory: a Model Interaction between Neurochemical and Environmental Influences in the Control of Schizophrenia

“…Such an apparent paradox may in fact be consistent with the clinical literature, where Brown et al (1972) have reported that too enthusiastic attempts at reactivating unprepared long stay schizophrenic patients can lead to sudden relapse of symptoms that had not been present for years. Goldberg et al (1977) have similarly reported that major role therapy, combining social casework and vocational rehabilitation, can have antitherapeutic effects in some pa tients; their conclusion, that patients can be provoked into a mental state they can no longer manage, resulting in panic and exacerbation of symptoms, is clearly consistent with our model. This suggests that well ¡mentioned but over zealous psychosocial treatments must be used with caution, though controlled use can have therapeutic effects (Carpenter et al, 1977).…”

A randomized controlled trial of evidence-based supported employment: Nonvocational outcomes

“…The findings of this study complement the pattern of results from prior randomized controlled trials demonstrating that IPS generally has no direct effects on improvements or deterioration in nonvocational domains across time. The finding that participation in high expectation employment programs are associated with worse nonvocational outcomes [14] simply has not received support in the current study or in prior studies of IPS [4]. Moreover, one possible interpretation for our finding that both IPS and DPA accumulated fewer days of hospitalization across the two-year follow-up is consistent with a recent finding suggesting a beneficial impact of IPS services on reduced psychiatric hospitalizations.…”

Outcome in Schizophrenic and Similar Paranoid Psychoses

“…Moreover, the relationships between the five IMPS syndromes at discharge and followup were syndrome-specific. The prognostic importance of differentiated psychopathological data at discharge was also noted by other authors (Mintz, O'Brien, and Luborsky 1976;Goldberg et al 1977;Wittenborn, McDonald, and Maurer 1977). In the IPSS such relationships could not be detected because psychopathological state was assessed on an index day but not at discharge (Strauss andCarpenter 1974, 1977;World Health Organization 1979).…”