Prediction of Premature Ovarian Insuffi ciency and prevalence of medical diseases

Abstract

Background: Premature Ovarian Failure (POF) represents 1% among women below the age of 40 and can be diagnosed by two levels of serum Follicular Stimulating Hormone (FSH) ≥40mIU/mlat 6 weeks apart. There are many reasons for POF and commonly is idiopathic (60% to 80%). POF has a negative impact on the psychological, social and quality of life of females.Objective: This study aims to fi nd the possibility of prediction of Premature Ovarian Insuffi ciency (POI) and its relation to medical disorders. Materials and methods:A retrospective study was conducted at the National Center for Diagnosis and Treatment of Infertility-Misurata, Libya. A total of 350 patients with POI were involved. The Inclusion Criteria were: age <40 years, with high serum FSH level, low Anti-Mullrian Hormone (AMH) and low Antra-Follicular Count (AFC). The hormonal essay including FSH, Luteinzing Hormone (LH), Estradiol (E2), Thyroid-Stimulating Hormone (TSH), Prolactin and Fasting Blood Sugar (FBS) along with the medical history was collected. Results:Overall collected cases had a mean age (31.19±3.86 years) and the medical disorders represented 47% of POI causes. Hypothyroidism, Hyperprolactinemia and Diabetes Mellitus were the most common associated disorders (31%, 30%, 14% respectively). The increase in the level of FSH (14.78±12.87) was the most sensitive test to predict POI especially in hypothyroidism cases, which could help to predict ovarian failure in those groups of people. Conclusion:There is a strong association between POI and medical conditions especially Hypothyroidism. Changes in FSH are the most sensitive test among ovarian markers to predict POF.

Comparison of metabolic profile in between women with premature ovarian insufficiency and normal women

“…3 However, in POI, intermittent and unpredictable resumption may occur in ovarian activity. 4 European society of human reproduction and endocrinology (ESHRE) has confirmed the term POI for research and clinical practice.…”

Thyroid Stimulating Hormone Concentration and Pregnancy Outcomes during Intra-Cytoplasmic Semen Injection Cycle

“…The ovulatory disorder is essential issue regarding the female fertility [3]. There are many factors affecting the ovarian function (ovulation) including genetic (chromosomal), infection, polycystic ovary, iatrogenic (chemotherapy and radiotherapy), endocrine disorders (diabetes mellitus, thyroid problem, hyperprolactinemia) [4,5].…”

“…Various research revealed that the most common endocrine abnormalities interfere with the ovulation is thyroid problem which consequently ended by Premature Ovarian Insufficiency (POI) [5]. From the gynecology point view, thyroid dysfunction could carry irregularity in menstrual cycle, unovulatory cycles, POI, infertility and even if the patient conceive could carry a high miscarriage rate, low live birth rate [6,7].…”