Prediction of Preeclampsia in Early Pregnancy by Estimating the Spot Urinary Albumin/Creatinine Ratio

Gupta, Nupur; Gupta, Taru; Asthana, Deepti

doi:10.1007/s13224-016-0958-z

Cited by 15 publications

(9 citation statements)

References 15 publications

(15 reference statements)

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“…The studies done by Poon et al, Upadhyay A et al, Devi LT et al, and Gupta et al showed that the URINE ALBUMIN TO CREATININE RATIO(UACR) values were significantly higher in the preeclampsia group when compared to the normotensive group with significant p-value. [24][25][26] In the present study, the sensitivity and specificity of spot urine albumin to creatinine ratio in the prediction of preeclampsia was 85% and 91%, respectively. Therefore, the spot UACR may be helpful to predict early onset preeclampsia.…”

Section: Discussionsupporting

confidence: 48%

See 1 more Smart Citation

Preeclampsia prediction –First trimester screening markers

Hymavathi¹,

Paturi²,

Akshitha³

et al. 2021

IJOGR

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Preeclampsia is a multi-system disorder manifested primarily by hypertension and proteinuria during second half of pregnancy. It is a major cause of maternal morbidity and mortality worldwide. Despite decades of research into the condition, the ability of clinicians to predict preeclampsia prior to the onset of symptoms has not improved significantly. In this review we will look at potential biomarkers for early prediction and diagnosis of preeclampsia. To evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia. This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal urine microalbumin, urinary albumin to creatinine ratio, and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers are: immunoturbidimetric method for urine albumin, modified kinetic Jaffe reaction without deproteinization for Urine creatinine and Uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer. In the present study, spot urine microalbumin and spot urine albumin to creatinine ratio (UACR) at 11-13 were significantly higher in women who developed PE subsequently when compared to nonpreeclamptic women.(P<0.0001). The mean levels of 1st and 2nd-trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (P<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal urine microalbumin, albumin to creatinine ratio, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE. Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, microalbuminuria and urine albumin to creatinine ratio than the normotensive women. In our setting, MAP, UAPI, microalbuminuria, and UACR markers appeared to be better screening modalities. The combination of biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

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Section: Discussionsupporting

confidence: 48%

“…Gupta et al shows the Cesarean section rate is significantly higher in the preeclampsia group when compared to the normotensive group. 27 (p value 0.001). But as per Zadeh et al, there was no significant difference observed in type of delivery between Preeclampsia and normotensive groups.…”

Section: Discussionmentioning

confidence: 97%

Preeclampsia prediction –First trimester screening markers

Hymavathi¹,

Paturi²,

Akshitha³

et al. 2021

IJOGR

View full text Add to dashboard Cite

show abstract

“…Gupta et al showed the cesarean section rate is significantly higher in the preeclampsia group when compared to the normotensive group (p value 0.001). 26 But as per Zadeh et al, there was no significant difference observed in type of delivery between preeclampsia and normotensive groups. 18 Our study findings found to be consistent with Zadeh et al study showing no statistically significant difference between 2 groups (p=0.149).…”

Section: Discussionmentioning

confidence: 80%

Potential screening strategies for early prediction of pre-eclampsia

Hymavathi

Davuluru

Shaik

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

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“…Singh et al (2015) identified the presence of microalbuminuria at 28-30 weeks of gestation to be predictive of subsequent preeclampsia with an odds ratio of 2.1 (95% CI 1.26-3.53). Another study showed that microalbuminuria at 10-12 weeks of gestation had 50% of sensitivity, 58% specificity, 50% PPV and 91% NPV for the later development of preeclampsia (Gupta et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Clinico-Demographic Profiles and Urinary Albumin in Prediction of Preeclampsia among Pregnant Women at a Tertiary Care Hospital

Begum¹,

Ali²,

Khanam³

et al. 2019

J Sci Found

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Background: The clinical profiles and urinary albumin are very important for the prediction of preeclampsia among the pregnant women. Objective: The purpose of the present study was to assess the clinical and demographic profiles as well as the urinary albumin for the prediction of preeclampsia among the pregnant women. Methodology: This cohort study was conducted in the OPD of the Department of Obstetrics and Gynaecology at Rajshahi Medical College Hospital, Rajshahi, Bangladesh from January 2013 to December 2014 for a period of two (2) years. This study was carried on pregnant woman attending in outdoor department of Gynaecology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh before 20th weeks of pregnancy who were healthy normotensive primigravidae with singleton pregnancy. The details demographic profiles, edema were collected from the study population. Urinary albumin was estimated before 20th weeks and after 28th weeks of pregnancy. Result: In the present study, 75 women were included; all were before 20th weeks of pregnancy without any complication or any risk factor for developing PE. Among the study group incidence of PE was 16%. The population are 24(32.0%) low, 31(41.3%) middle and 20(26.7%) high in socio economic conditions. Education level of study population was 45% completed primary education level, illiterate (27%) and secondary education (28%). Edema was absent in 1st visit, in 2nd visit 6(+), 6(++) present who developed PE, 18(+) present who did not develop PE. Edema was absent in 1st visit and (+) 6(50.0%) and (++) in 6(50.0%) present who developed PE in 2nd visit. Urine albumin in 1st visit nil in 6(50.0%), trace in 3(25.0%) and (+) in 3(25.0%) who developed PE. Conclusion: In conclusion housewife living in urban area in middle income socioeconomic condition are the most commonly presented with preeclampsia and urinary albumin is the most commonly detected in the pregnant women presented with preeclampsia Journal of Science Foundation 2018;16(2):54-59

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Prediction of Preeclampsia in Early Pregnancy by Estimating the Spot Urinary Albumin/Creatinine Ratio

Cited by 15 publications

References 15 publications

Preeclampsia prediction –First trimester screening markers

Preeclampsia prediction –First trimester screening markers

Potential screening strategies for early prediction of pre-eclampsia

Clinico-Demographic Profiles and Urinary Albumin in Prediction of Preeclampsia among Pregnant Women at a Tertiary Care Hospital

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