Prediction of Periodontitis Occurrence: Influence of Classification and Sociodemographic and General Health Information

Leite, Fábio Renato Manzolli; Peres, Karen Glazer; Do, Loc; Demarco, Flávio Fernando; Peres, Marco Aurélio

doi:10.1902/jop.2017.160607

Cited by 32 publications

(46 citation statements)

References 54 publications

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“…The lowest intraclass correlation coefficient for periodontal examination was 0.85 . Differences ≤1 mm within and among examiners were considered as acceptable measurement errors …”

Section: Methodsmentioning

confidence: 99%

Metabolic syndrome and periodontitis: A structural equation modeling approach

Nascimento

Leite

Peres

et al. 2018

Journal of Periodontology

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Background: This study aimed to investigate the association between metabolic syndrome (MetS) and periodontitis among young adults, and also to compare results using observed and latent variables for MetS and periodontitis.Methods: Data from the 1982 Pelotas Birth Cohort, Brazil, were used. Metabolic syndrome at the age of 23 years was measured using clinical and biochemical analysis and set as the main exposure. Periodontitis at the age of 31 years was clinically measured and set as the outcome. Confounding variables included sex and maternal education, assessed at birth, family income at 23 years, and smoking status at the age of 23 and 30 years. Factor analyses (exploratory and confirmatory) were performed to define latent variables for MetS and periodontitis. In addition, both conditions were also defined as categorical observed variables. The association between MetS and periodontitis was tested in structural equation models.Results: Two latent periodontal variables were identified: "initial" and "advanced" periodontitis, while one latent variable was identified for MetS. Metabolic syndrome is positively associated with "advanced" (coefficient 0.11; P value < 0.01), but not with "initial" (coefficient -0.01; P value = 0.79) periodontitis. When MetS and periodontitis were set as observed variables in the structural equation models, no association was found irrespective of the criteria used for periodontitis classification. Conclusions:There was a positive association between metabolic syndrome and "advanced" periodontitis, when the multiple dimensions of both diseases were accounted in latent variables. Nevertheless, when MetS and periodontitis were treated as observed variables, no association was detected irrespective of the criteria used for periodontitis classification. K E Y W O R D Scohort studies, longitudinal studies, methods, periodontal diseases INTRODUCTIONMetabolic syndrome (MetS) is a cluster of metabolic abnormalities including abdominal obesity, hypertension, insulin resistance, and atherogenic dyslipidemia, associated with increased risk of diabetes and cardiovascular events. 1 The supposed link between MetS and periodontitis may be related to increased levels of proinflammatory cytokines, oxidative stress, 2 abdominal obesity, 3 and hyperglycemia. 4 Furthermore, common risk factors including health behaviors, such as smoking, unhealthy diet, and low socioeconomic position 5,6 may also be responsible for this association. A meta-analysis J Periodontol. 2019;90:655-662.

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“…The lowest intraclass correlation coefficient for periodontal examination was 0.85 . Differences ≤1 mm within and among examiners were considered as acceptable measurement errors …”

Section: Methodsmentioning

confidence: 99%

Metabolic syndrome and periodontitis: A structural equation modeling approach

Nascimento

Leite

Peres

et al. 2018

Journal of Periodontology

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“…Independent variables were analyzed by using decision tree analysis (DTA) with the classification and regression tree (CART) and Chi-squared automatic interaction detection (CHAID) approaches. 15 DTA analyses were conducted using statistical software (SPSS 24.0, IBM Corp.). Outcome variables were then dichotomized for the ease of data interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…Descriptive statistics using the mean, standard deviation, and frequency was applied. Independent variables were analyzed by using decision tree analysis (DTA) with the classification and regression tree (CART) and Chi‐squared automatic interaction detection (CHAID) approaches . DTA analyses were conducted using statistical software (SPSS 24.0, IBM Corp.).…”

Section: Methodsmentioning

confidence: 99%

“…Even though some studies have reported complications related to peri‐implant conditions, we lack clinical investigations on the identification of predictive factors of early bone loss around morse taper implant connections. Most of the studies on the topic used statistical models that include only previously established risk factors, leading to a misunderstanding between predicting and explaining . The use of prediction techniques provides the opportunity to test new theories and to discover new hypothetical mechanisms and relations among variables alongside explanatory modeling .…”

Section: Introductionmentioning

confidence: 99%

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Early‐predictors of marginal bone loss around morse taper connection implants loaded with single crowns: A prospective longitudinal study

Radaelli

Federizzi

Nascimento

et al. 2019

J of Periodontal Research

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Background and Objective Few studies estimated the joint effect of implant design (length and diameter), peri‐implant, and occlusal variables on early marginal bone loss. The monitoring of these factors during the first year after implant loading may be effective in preventing early implant failure. This prospective longitudinal study aimed to identify early‐predictors of marginal bone loss around morse‐tapered connection implants 12 months after implant loading. Methods Participants (n = 33) received 109 morse taper implants inserted subcrestally (diameter: 3.5 to 5 mm, length: 6 to 15 mm) loaded with single crowns. Implants were radiographically examined at the implant placement (baseline) and 12 months after prosthetic loading. Implant, peri‐implant, and occlusal‐related independent variables were analyzed by decision tree analysis. Mixed‐effects multilevel analysis was used to estimate adjusted predictive values of marginal bone loss based on the early‐predictors identified in decision tree analysis. Results Higher marginal bone loss was observed at mesial (mean of 0.87 mm; ranged from 0.5 to 1.19) than at distal sites (mean of 0.73 mm; ranged from 0.4 to 1.12 mm). The predictive model revealed of the largest marginal bone loss in association with cement‐retained prostheses, a platform diameter of 3.5 mm, papilla sizes up to 2 mm, keratinized mucosa width inferior to 3 mm, implant lengths above 8.5 mm, inadequate occlusal relations, presence of bleeding on probing and deep peri‐implant pocket. Conclusion As implant dimensions, peri‐implant and occlusal‐related factors were associated with early marginal bone loss around morse taper implant, intervention in these factors might prevent early marginal bone loss.

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“…Based on its direct relationship with systemic diseases, periodontitis is a risk factor for cardiovascular diseases and may exacerbate the complications of diabetes and those of some systemic disorders such as those of genetic, inflammatory, metabolic, and endocrine origins, which can directly affect the loss of periodontal tissues [5]. Possible pathways involved in this process include persistent, low-grade systemic inflammation caused by disseminated proinflammatory mediators and periodontium-originating bacteremia [6].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Periodontal Therapy Recovered the Phagocytic Function of Monocytes in Periodontitis

Naiff

Carneiro

Guimarães

et al. 2020

International Journal of Dentistry

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Background. Several studies have focused on the association between periodontitis and systemic implications; however, the biological mechanisms of the immune responses before and after periodontal therapy involved in this relationship, such as phagocytic functions, remain unclear. Objectives. This study aimed to investigate whether periodontal treatment improves the phagocytic function of blood monocytes in patients with severe periodontitis. Materials and Methods. A nonrandomized sample of 55 participants was enrolled in the study. Two groups were studied: control (n = 27, healthy subjects without periodontal disease) and patients (n = 28, individuals with periodontitis). Treatment of periodontitis (scaling and root planing) was performed until the clinical resolution of periodontal pockets and inflammation. The following clinical periodontal parameters were assessed: probing depth, clinical attachment level, visible plaque index (PI), and gingival bleeding on probing index before and after mechanical periodontal treatment. The phagocytic index (PhI) and nitro blue tetrazolium test (NBT) were assessed before and immediately after the end of treatment. Results. Periodontitis induced impaired phagocytosis by monocytes. Phagocytosis at baseline was significantly lower in periodontitis patients [median, 13.2 (range of 7.1 to 20.8) and 60.7 (40.6 to 88.6)] than in controls [27.4 (15.5 to 40.5)] and 98 (68.2 to 122.9)] for nonsensitized or sensitized samples, respectively. After supportive therapy, patients showed a significant enhancement of phagocytic functions [33.7 (14.6 to 53.2) and 108.5 (99.6 to 159.5)] for nonsensitized and sensitized samples, respectively. Periodontal treatment increased the phagocytic capacity to a level similar to that observed in the control group and improved the capacity of phagocytes to produce superoxide anion. Conclusions. The results suggest that periodontal therapy in patients with severe periodontitis provides a state of homeostasis due to the reestablishment of phagocytic function and increased production of NBT (Regional Registry No. RBR-24T799; Universal Registry No. U1111-1133-5512).

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Prediction of Periodontitis Occurrence: Influence of Classification and Sociodemographic and General Health Information

Cited by 32 publications

References 54 publications

Metabolic syndrome and periodontitis: A structural equation modeling approach

Metabolic syndrome and periodontitis: A structural equation modeling approach

Early‐predictors of marginal bone loss around morse taper connection implants loaded with single crowns: A prospective longitudinal study

Mechanical Periodontal Therapy Recovered the Phagocytic Function of Monocytes in Periodontitis

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