Prediction of Coronary Artery Disease Extent and Severity Using Pulse Wave Velocity

Abstract

BackgroundPulse-wave velocity (PWV) measures aortic stiffness. It is an independent predictor of cardiovascular events and mortality, yet there is paucity in the literature on its association with the severity and extent of coronary artery disease (CAD).MethodsTo examine the utility of PWV in predicting CAD burden in men and women the PWV was determined in 344 patients (Men = 266, Women = 78) presenting for invasive coronary angiography for the assessment of suspected CAD. Pearson correlations and multivariate analysis were used to evaluate the relationship between these coronary scores, PWV and traditional cardiovascular risk factors.ResultsCompared to men, women with chest pain had lower mean Extent scores (19.2 vs. 35.6; p = 0.0001) and Gensini scores (23.6 vs. 41.9; p = 0.0001). PWV was similar between men and women (12.35 ± 3.74 vs. 12.43 ± 4.58; p = 0.88) and correlated with Extent score (r = 0.21, p = 0.0001) but not Gensini or vessel score (r = 0.03, p = 0.64 and r = 0.06, p = 0.26, respectively). PWV was associated with Extent score in men (B = 2.25 ± 0.78, p = 0.004 for men and B = 1.50 ± 0.88, p = 0.09 for women). It was not a predictor of Gensini score (B = -0.10, P = 0.90).ConclusionPWV correlates with the extent of CAD, as measured by the ‘Extent’ score in men more than women. However, it does not correlate with the severity of obstructive CAD in either gender.

Ambulatory blood pressure and arterial stiffness web‐based telemonitoring in patients at cardiovascular risk. First results of the VASOTENS (Vascular health ASsessment Of The hypertENSive patients) Registry

“…This is in part confirmed in the patients of our study with known CV disease, in whom we observed a trend to larger PWV and AIx values compared to patients free from CV disease, a trend which was consistently reappraised when we adjusted the results for confounding factors. The limited sample of participants with CV disease in our study could have prevented to show differences in arterial stiffness and wave reflections found in previous studies performed in resting conditions in patients with CV disease . The longitudinal phase of the VASOTENS Registry may help us better clarify this aspect.…”

“…The limited sample of participants with CV disease in our study could have prevented to show differences in arterial stiffness and wave reflections found in previous studies performed in resting conditions in patients with CV disease. [44][45][46] The longitudinal phase of the VASOTENS Registry may help us better clarify this aspect.…”

Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms

“…Similarly, in asymptomatic individuals, PWV was identified as an independent prognostic factor for the presence of CAD diagnosed by CCTA . In symptomatic patients, PWV levels were positively related to the presence and severity of CAD as assessed by invasive coronary angiography . Furthermore, osteoprotegerin and osteopontin levels have been associated with CAD progression through arterial wall stiffening and inflammation.…”

“…15,35,36 In symptomatic patients, PWV levels were positively related to the presence and severity of CAD as assessed by invasive coronary angiography. 13,[37][38][39] Furthermore, osteoprotegerin and osteopontin levels have been associated with CAD progression through arterial wall stiffening and inflammation.…”

Body mass index influence the association between triglyceride-glucose index and atherosclerosis in community population: the cardiometabolic risk in Chinese (CRC) study

“…Pulse wave velocity (PWV) is one of the indicators for evaluating AS [6]. It is the most commonly used non-invasive measure of arterial stiffness and can be used as an indicator for reflecting AS and predicting cardiovascular events [7]. PWV measured at different sites can reflect the atherosclerotic alterations at central (e.g.…”