volume 275, issue 1-2, P133-139 2004
DOI: 10.1016/j.ijpharm.2004.01.028
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Abstract: Organic salts of diclofenac were predicted by using computed molecular descriptors and multivariate partial least squares (PLS). The molecular descriptors including binding energy and surface area of salts were calculated by the use of Hyperchem and ChemPlus QSAR programs for Windows. Other physicochemical properties such as hydrogen acceptor for oxygen atoms, hydrogen acceptor for nitrogen atoms, hydrogen bond donors, hydrogen bond-forming ability, molecular weight, and log partition coefficient (logP) of bas…

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