Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis

Abstract

We demonstrate that AFC and AMH add value to female age in the prediction of excessive response and that, for AFC and FSH, the discriminatory performance is affected by female age.

Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials

“…Consistent with previous systematic reviews and individual patient data meta-analyses (4,23,24), other predictors of ovarian response to gonadotropin stimulation, such as FSH, were shown to be less predictive than AMH in both trials (18,19) and therefore not considered for this evaluation.…”

Hormon anty-müllerowski i zespół policystycznych jajników

“…Seifer et al first described AMH concentrations corresponding to a number of oocytes retrieved and mature oocytes in infertile women [59]. It has been shown that AMH is a good predictor of high and low ovarian response during ovarian stimulation [27,60]. New ultrasensitive method of measurement of AMH -picoAMH immunoassay -allows estimation of very low AMH concentrations [57].…”

“…Seifer i wsp., jako jedni z pierwszych badaczy, opisali, że AMH koreluje z liczbą uzyskanych oocytów u kobiet z niepłodno-ścią [59]. Dotychczasowe badania określają AMH jako czynnik predykcyjny zarówno zwiększonej, jak i zmniejszonej odpowiedzi jajników na stymulację mnogiego jajeczkowania [27,60]. Nowe technikiultraczułe oznaczenie AMH w surowicy krwi metodą picoAMH -pozwalają na wykrycie bardzo niskich stężeń AMH [57].…”

Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

“…In a single-center study with identical ultrasound machines over the study period and identical personnel undertaking the ultrasound scans, many of these limitations are expected to be minimized. This conformity may explain why AFC has performed so well in single-center and individual-patient data meta-analyses of ovarian response prediction (36,37). Despite this strength we still observe poorer model performance in the model that solely incorporated AFC as compared with AMH.…”