Predicting Tissue Susceptibility to Mechanical Cavitation Damage in Therapeutic Ultrasound

Mancia, Lauren; Vlaisavljevich, Eli; Xu, Zhen; Johnsen, Eric

doi:10.1016/j.ultrasmedbio.2017.02.020

Cited by 61 publications

(113 citation statements)

References 33 publications

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“…Most soft solids exhibit viscoelastic behavior, and cavitation rheology techniques (see Fig. 3) span strain rates from the quasistatic regime (10 −4 s −1 ) to the ultrahigh strain rate regime (10 8 s −1 ) (33)(34)(35)(36). Furthermore, both the strain and strain rate inside a cavitating soft solid can vary dramatically, leading to spatially dependent viscoelastic contributions to cavity dynamics (37)(38)(39).…”

Section: Cavitation Mechanics and Dynamicsmentioning

confidence: 99%

Cavitation in soft matter

Barney

Dougan

McLeod

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

109

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Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. Cavitation rheology is a field emerging from the development of a suite of materials characterization, damage quantification, and therapeutic techniques that exploit the physical principles of cavitation. Cavitation rheology is inherently complex and broad in scope with wide-ranging applications in the biology, chemistry, materials, and mechanics communities. This perspective aims to drive collaboration among these communities and guide discussion by defining a common core of highpriority goals while highlighting emerging opportunities in the field of cavitation rheology. A brief overview of the mechanics and dynamics of cavitation in soft matter is presented. This overview is followed by a discussion of the overarching goals of cavitation rheology and an overview of common experimental techniques. The larger unmet needs and challenges of cavitation in soft matter are then presented alongside specific opportunities for researchers from different disciplines to contribute to the field. soft solids | traumatic brain injury | TBI | rheology | bubble Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. While predominantly studied in fluids, cavitation is also an origin of damage in soft materials, including biological tissues. Examples of cavitation in fluids and soft solids are shown in Fig. 1 A-C. As one key example, strong evidence suggests that cavitation occurs in the brain during sudden impacts, leading to traumatic brain injury (TBI) (3). Research on this life-impacting injury and its relation to cavitation has accelerated in recent years (4-8). A broader and deeper understanding of cavitation within soft matter is necessary to navigate the complex paths that lead to damage in the brain and other soft materials. Cavitation in fluids has been studied extensively since Rayleigh's (9) formulation in 1917, which predicted that the maximum pressure in a cavitating liquid is proportional to the far-field pressure and inversely proportional to the cavity size. As surface energy

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Section: Cavitation Mechanics and Dynamicsmentioning

confidence: 99%

Cavitation in soft matter

Barney

Dougan

McLeod

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

109

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“…The dynamics of a single isolated, spherical, gas-filled bubble in both water and in homogeneous viscoelastic media (representative of the agarose gels) are numerically simulated using an approach similar to previous studies of histotripsy cavitation [25,26,[46][47][48]. In the present study, only acoustically nucleated bubbles are modeled.…”

Section: B Theoretical Modelingmentioning

confidence: 99%

Comparative study of the dynamics of laser and acoustically generated bubbles in viscoelastic media

et al. 2019

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Experimental observations of the growth and collapse of acoustically and laser-nucleated single bubbles in water and agarose gels of varying stiffness are presented. The maximum radii of generated bubbles decreased as the stiffness of the media increased for both nucleation modalities, but the maximum radii of laser-nucleated bubbles decreased more rapidly than acoustically nucleated bubbles as the gel stiffness increased. For water and low stiffness gels, the collapse times were well predicted by a Rayleigh cavity, but bubbles collapsed faster than predicted in the higher stiffness gels. The growth and collapse phases occurred symmetrically (in time) about the maximum radius in water but not in gels, where the duration of the growth phase decreased more than the collapse phase as gel stiffness increased. Numerical simulations of the bubble dynamics in viscoelastic media showed varying degrees of success in accurately predicting the observations.

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“…In general, the highly non-linear nature of the Ray-leighÀPlesset equation necessitates numerical solutions, and bubble expansion by histotripsy pulses has been explored numerically by several groups (Bader and Holland 2016;Mancia et al 2017;Maxwell et al 2013;Movahed et al 2016;Vlaisavljevich et al 2015c;Pahk et al 2015). The tensions well in excess of the Blake threshold for histotripsy pulses simplify the RayleighÀPlesset equation significantly, and the maximum bubble size can be predicted with high accuracy for a single-cycle excitation analytically (Bader and Holland 2016):…”

Section: Bubble Dynamics Modelingmentioning

confidence: 99%

For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy

Bader

Vlaisavljevich

Maxwell

2019

Ultrasound in Medicine & Biology

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143

114

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Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of bubble clouds for tissue destruction. Although acoustic bubble activity is often characterized as chaotic, the short-duration histotripsy pulses produce a unique and consistent type of cavitation for tissue destruction. In this review, the action of histotripsyinduced bubbles is discussed. Sources of bubble nuclei are reviewed, and bubble activity over the course of single and multiple pulses is outlined. Recent innovations in terms of novel acoustic excitations, exogenous nuclei for targeted ablation and histotripsy-enhanced drug delivery and image guidance metrics are discussed. Finally, gaps in knowledge of the histotripsy process are highlighted, along with suggested means to expedite widespread clinical utilization of histotripsy.

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Predicting Tissue Susceptibility to Mechanical Cavitation Damage in Therapeutic Ultrasound

Cited by 61 publications

References 33 publications

Cavitation in soft matter

Cavitation in soft matter

Comparative study of the dynamics of laser and acoustically generated bubbles in viscoelastic media

For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy

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