Predicting the aquatic risk of realistic pesticide mixtures to species assemblages in Portuguese river basins

Silva, Emília; Daam, Michiel A.; Cerejeira, Maria José

doi:10.1016/j.jes.2014.11.006

Cited by 32 publications

(25 citation statements)

References 20 publications

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“…However, studies of this type, and studies at the molecular level (such as the present study), are also imperative to allow increasing our mechanistic understanding of chemical mixture toxicity (Jager et al, 2014). Ultimately, this will also aid in developing practical criteria for the selection of chemical mixtures that are likely to exert synergistic interactions at environmentally realistic concentrations and hence require further (legislative) attention (Altenburger et al, 2013;Coors et al, 2013;Silva et al, 2015).…”

Section: Gene Expressionmentioning

confidence: 92%

The use of gene expression to unravel the single and mixture toxicity of abamectin and difenoconazole on survival and reproduction of the springtail Folsomia candida

Figueirêdo

Daam

Mainardi

et al. 2019

Environmental Pollution

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Pesticides risk assessments have traditionally focused on the effects on standard parameters, such as mortality, reproduction and development. However, one of the first signs of adverse effects that occur in organisms exposed to stress conditions is an alteration in their genomic expression, which is specific to the type of stress, sensitive to very low contaminant concentrations and responsive in a few hours. The aim of the present study was to evaluate the single and binary mixture toxicity of commercial products of abamectin (Kraft ® 36 EC) and difenoconazole (Score ® 250 EC) to Folsomia candida. Laboratory toxicity tests were conducted to access the effects of these pesticides on springtail survival, reproduction and gene expression. The reproduction assays gave EC 50 and EC 10 values, respectively, of 6.3 and 1.4 mg a.s./ kg dry soil for abamectin; 1.0 and 0.12 mg a.s./kg dry soil for Kraft ® 36 EC; and 54 and 23 mg a.s./kg dry soil for Score ® 250 EC. Technical difenoconazole did not have any effect at the concentrations tested. No significant differences in gene expression were found between the abamectin concentrations tested (EC 10 and EC 50) and the solvent control. Exposure to Kraft ® 36 EC, however, significantly induced Cyp6 expression at the EC 50 level, while VgR was significantly downregulated at both the EC 10 and EC 50. Exposure to the simple pesticide mixture of Kraft ® 36 EC þ Score ® 250 EC caused significant up regulation of ABC transporter, and significant down regulation of VgR relative to the controls. GABA receptor also showed significant down-regulation between the EC 10 and EC 50 mixture treatments. Results of the present study demonstrate that pesticide-induced gene expression effects precede and occur at lower concentrations than organism-level responses. Integrating "omic" endpoints in traditional bioassays may thus be a promising way forward in pesticide toxicity evaluations.

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Section: Gene Expressionmentioning

confidence: 92%

The use of gene expression to unravel the single and mixture toxicity of abamectin and difenoconazole on survival and reproduction of the springtail Folsomia candida

Figueirêdo

Daam

Mainardi

et al. 2019

Environmental Pollution

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“…Such use is an advantage for the farmer, since it amplifies the spectrum of action of the herbicides. However, as previously demonstrated for pesticide mixtures, their use can amplify the toxic effects of each component on nontarget organisms (Laetz et al., 2009; Prestes et al., 2011; Silva et al., 2015).…”

Section: Introductionmentioning

confidence: 88%

Bioconcentrations of herbicides used in sugarcane crops in tilapia (Oreochromis niloticus) and the risk for human consumption

Jonsson¹,

Moura

Ferracini³

et al. 2019

Heliyon

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The practice of intensive herbicide use in the sugarcane industry has a high risk of compromising the quality of the water and the organisms that live there due to losses through runoff, leaching and other processes. In this work, the dynamics of four herbicides present in three different mixtures were evaluated through their incorporation and elimination in the muscle tissue of tilapia ( Oreochromis niloticus ). The highest mean values of bioconcentration factors were 1.730 for ametryn, 0.891 for tebuthiuron, 0.322 for hexazinone and 4.783 for diuron. Diuron presented the highest risk regarding the consumption of tilapia fillets by the population. However, considering that the fish would reach maximum levels of diuron when exposed to extremely high concentrations, an individual weighing 70 kg would need to ingest approximately 1.5 kg of this food product to surpass the acceptable daily intake of 0.007 mg kg −1 body weight. It was concluded that the risk of injury to the population consuming tilapia fillets from fish exposed to herbicides in water arising from sugarcane activities is very low. According to the risk estimation performed in this work, which is substantiated by the assumptions of the World Health Organization and the International Life Sciences Institute, there is a low risk of injury to the population consuming tilapia fillets from fish exposed to water containing herbicides in concentrations arising from sugarcane activities. However, as the risk was estimated from laboratory conditions, caution should be taken where herbicide applications are carried out with high frequency near water bodies, as the consumption of fish from these areas is quite common.

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“…Among many compounds of anthropogenic origin, pesticides that are used to enhance agricultural yields are extensively used and spread in all environmental compartments (Silva et al, 2015). All these compounds are finally found in surface water and in groundwater (Devault et al, 2007;Carvalho et al, 2014;Baker et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of herbicide mixtures on freshwater microalgae with the potential effect of a safener

Chamsi

Pinelli

Faucon

et al. 2019

Ann. Limnol. - Int. J. Lim.

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Freshwater microalgae are primary producers and cosmopolitan species subjected to the effects of herbicides. In this work, the in vitro algal growth inhibitory effects of 11 agrochemicals (9 herbicides, 1 metabolite, and 1 safener) were quantified. Chemical compounds were applied singly and in specific mixtures. Three species were used in axenic condition: the green alga Desmodesmus subspicatus (Chodat), the diatoms Nitzschia palea (Kützing) W. Smith and Navicula pelliculosa (Kützing) Hilse. When exposed to single compounds, N. palea and N. pelliculosa were only sensitive to atrazine/desethylatrazine and the safener benoxacor (BE), respectively. D. subspicatus was equally sensitive to four herbicides including atrazine and its metabolite and significantly more sensitive to iodosulfuron-methyl-sodium (IODO). The mixture of these five compounds induced a significantly higher growth inhibition of about 1.5-fold than IODO alone, which could be attributed to the four other herbicides. The mixture of all compounds was twofold less toxic than IODO on D. subspicatus. A halogen atom is present in IODO as in the herbicides to which the safener BE À known to induce glutathione-S-transferases À is associated in agrochemical preparations. We then showed that IODO was less toxic when combined with non-toxic concentrations of BE. These results indicated that the toxicity of the most active herbicide studied was decreased by a non-herbicide compound present in agrochemical formulations of other herbicides. These results suggest the importance to take into account the chemistry and the mechanisms of action for each compound in a risk assessment approach of a complex mixture.

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Predicting the aquatic risk of realistic pesticide mixtures to species assemblages in Portuguese river basins

Cited by 32 publications

References 20 publications

The use of gene expression to unravel the single and mixture toxicity of abamectin and difenoconazole on survival and reproduction of the springtail Folsomia candida

The use of gene expression to unravel the single and mixture toxicity of abamectin and difenoconazole on survival and reproduction of the springtail Folsomia candida

Bioconcentrations of herbicides used in sugarcane crops in tilapia (Oreochromis niloticus) and the risk for human consumption

Effects of herbicide mixtures on freshwater microalgae with the potential effect of a safener

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