Predicting glucocorticoid resistance in multiple sclerosis relapse via a whole blood transcriptomic analysis
Maud Bagnoud,
Jana Remlinger,
Sandrine Joly
et al.
Abstract:AimsTreatment of multiple sclerosis (MS) relapses consists of short‐term administration of high‐dose glucocorticoids (GCs). However, over 40% of patients show an insufficient response to GC treatment. We aimed to develop a predictive model for such GC resistance.MethodsWe performed a receiver operating characteristic (ROC) curve analysis following the transcriptomic assay of whole blood samples from stable, relapsing GC‐sensitive and relapsing GC‐resistant patients with MS in two different European centers.Res… Show more
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