Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR

Alptekın, Husnu; CİZMECİOGLU, Ahmet; Işık, Hatice; Cengiz, Türkan; Yıldız, Melda; İyisoy, Mehmet Sinan

doi:10.1007/s40618-015-0427-z

Cited by 44 publications

(43 citation statements)

References 32 publications

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“…Accordingly, the multiparametric model showed no impact of BMI on the risk for future development of GDM, nor on the ROC curves performance when combined with P1GF. Interestingly, a recent multicentric randomized controlled trial enrolling pregnant women with a BMI ≥29 Kg/m 2 reported that a healthy eating intervention combined with physical exercise resulted in less gestational weight gain, with no impact, however, on reducing fasting plasma glucose …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, a recent multicentric randomized controlled trial enrolling pregnant women with a BMI ≥29 Kg/m 2 reported that a healthy eating intervention combined with physical exercise resulted in less gestational weight gain, with no impact, however, on reducing fasting plasma glucose. [28][29][30] Pregnancy increases the susceptibility of periodontal tissues to develop inflammation, 13 and this was more evident in patients with GDM. 10,12,31 Indeed, women with GDM have a greater risk for developing more severe periodontal disease than normal healthy pregnant women.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

Chaparro

Zuñiga

Varas-Godoy

et al. 2018

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

Chaparro

Zuñiga

Varas-Godoy

et al. 2018

Journal of Periodontology

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“…However, evidence has been largely confined to non-pregnant individuals. Data on the association between central obesity in early pregnancy and risk of GDM beyond established risk factors including overall obesity as measured by BMI are limited, mostly in small-scale studies including 10–80 women with GDM (11, 12, 13, 14). In particular, waist-to-hip ratio (WHR) and waist circumference (WC) have been established as simple and less expensive surrogate measures of central obesity with high correlations with intra-abdominal or visceral fat mass (15, 16), whereas data on WHR or WC in early pregnancy in relation to GDM risk are scant.…”

Section: Introductionmentioning

confidence: 99%

Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance

Zhu

Hedderson

Quesenberry

et al. 2018

Obesity

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Objective This study examined the associations of central obesity measures, waist to hip ratio (WHR) and waist circumference (WC), in early pregnancy with subsequent risk of gestational diabetes mellitus (GDM) and evaluated the potential mediating role of insulin resistance markers. Methods Within the prospective Pregnancy Environment and Lifestyle Study cohort of 1,750 women, WC and hip circumference were measured at gestational weeks 10 to 13. In a nested case‐control study within the cohort, 115 GDM cases and 230 controls had fasting serum insulin, homeostatic model assessment of insulin resistance (HOMA‐IR), and adiponectin measurements at gestational weeks 16 to 19. Poisson and conditional logistic regression models were used, adjusting for established risk factors for GDM, including prepregnancy overweight or obesity. Results For women with WHR < 0.85, one or more established risk factors increased GDM risk 1.99‐fold (95% CI: 0.99‐4.02). For women with WHR ≥ 0.85 but no established risk factors, GDM risk increased 2.41‐fold (95% CI: 1.14‐5.06), and in those with established risk factors it increased 6.22‐fold (95% CI: 3.49‐11.10). Similar but attenuated results were observed for WC ≥ 88 cm. Insulin, HOMA‐IR, and adiponectin levels mediated the WHR–GDM association by 9% to 11%; corresponding mediation proportions for the WC–GDM association were 35% to 41% (all P < 0.04). Conclusions Central obesity in early pregnancy represented a high‐risk phenotype for GDM independent of other risk factors, including overweight or obesity, and may inform early screening and prevention strategies.

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“…GDM is one of the most frequent metabolic diseases during pregnancy and approximately affects 7% (range: 2–18%) of all pregnancies [2–5]. This clinical condition potentially affects not only negative medical outcomes but also the mental health status with additional adverse consequences on psychological well-being and Quality of Life (QoL) [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Women with Gestational Diabetes Mellitus: A Systematic Review

Marchetti

Carrozzino

Fraticelli

et al. 2017

Journal of Diabetes Research

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Background and Objective. Diagnosis of Gestational Diabetes Mellitus (GDM) could significantly increase the likelihood of health problems concerning both potential risks for the mother, fetus, and child's development and negative effects on maternal mental health above all in terms of a diminished Quality of Life (QoL). The current systematic review study is aimed at further contributing to an advancement of knowledge about the clinical link between GDM and QoL. Methods. According to PRISMA guidelines, PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies aimed at evaluating and/or improving levels of QoL in women diagnosed with GDM. Results. Fifteen research studies were identified and qualitatively analyzed by summarizing results according to the following two topics: GDM and QoL and interventions on QoL in patients with GDM. Studies showed that, in women with GDM, QoL is significantly worse in both the short term and long term. However, improvements on QoL can be achieved through different intervention programs by enhancing positive diabetes-related self-management behaviors. Conclusion. Future studies are strongly recommended to further examine the impact of integrative programs, including telemedicine and educational interventions, on QoL of GDM patients by promoting their illness acceptance and healthy lifestyle behaviors.

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Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR

Abstract: First trimester screening for GDM can be achieved based on maternal anthropometric measurements and HOMA-IR. In particular, if BMI is >25.95 kg/m(2) and the HOMA-IR score >2.08, controlling weight gain may protect against GDM.

Cited by 44 publications

References 32 publications

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus

Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance

Quality of Life in Women with Gestational Diabetes Mellitus: A Systematic Review

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