Predicting Factors of Depression, Antidepressant Use and Positive Response to Antidepressants in Perinatal and Postpartum Women

Vu, Huyen Thi Thanh; Shaya, Fadia T.

doi:10.2174/1745017901713010049

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…This is ascribed to the possible negative interaction between mental disorders ( e.g ., depression) and poverty, primarily because, in principle, people with depression commonly perform poorly in their daily tasks [ 32 ]. Moreover, a number of studies carried out in high-income countries revealed that people with social and economic disadvantages are more likely to develop depression [ 33 ], indicating the substantial relationships between social adversity, HIV, and depression. Based on the world federation on mental health, women tend to suffer from depression two-fold more than men due to financial issues, lack of formal education, and potential exposure to violence [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiety and Depression Among Women Living with HIV: Prevalence and Correlations

Yousuf¹,

Musa²,

Isa³

et al. 2020

CPEMH

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Introduction: It has been found that HIV positive women are becoming increasingly affected by various illnesses, including Common Mental Disorders (CMDs) such as depression. Such comorbidity escalates the disease progression to the severe stage and commonly hinders treatment adherence. This study determined the prevalence of anxiety and depression amidst women living with HIV. Methods: Based on a cross-sectional and facility-based study, 357 HIV positive women were recruited using the systematic sampling technique from two public hospitals in Jijiga town, Ethiopia. The Hospital Anxiety and Depression Scale (HADS) was administered for screening, and followed by a pre-tested questionnaire that comprised of Perceived Social Support and HIV stigma. Results: The results revealed that the prevalence of both anxiety and depression amidst HIV positive women was 28.9% and 32.5%, respectively. In the multivariate analysis, it was discovered that lack of formal education, being divorced, unemployed, and earning a monthly income less than 1400 ETB (37.5 USD) were significantly associated with depression. Women with symptomatic HIV clinical stage III (AOR =2.06, 95% C.I (0.75-5.61), with CD4 cell count below 250 (AOR = 1.14, 95% C.I (0.57-2.28), and with co-infections (AOR= 1.04, 95% C.I (0.40-2.71) also suffered from depression. Conclusion: The study outcomes show that the prevalence of depression in women with HIV was 32.5%, but they were more likely to be depressed if they were illiterate, divorced, unemployed or had a financial burden. In addition, HIV positive women with less CD4 cell count and in the final clinical stage or suffered from a co-infection were also associated with depressive symptoms. This signifies the public health implications of psychological and cognitive morbidities of the illness among these women with chronic illnesses. Hence, future mental health interventions and HIV care should be integrated with substantial emphasis given to vulnerable groups, including HIV positive women.

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Section: Discussionmentioning

confidence: 99%

Anxiety and Depression Among Women Living with HIV: Prevalence and Correlations

Yousuf¹,

Musa²,

Isa³

et al. 2020

CPEMH

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“…Depression is a clinical syndrome characterized by significant and persistent depression, speech loss, mental and motor retardation, and various physical symptoms and dysfunctions (Jiang et al, 2018). Although antidepressants can improve some mental states of depression, these drugs have more side effects, such as apathy, sleep disorders, and cognitive dysfunction (Hsiao et al, 2015;Vu and Shaya, 2017). Traditional Chinese Medicine (TCM), as a complementary and alternative medicine, has been proven to possess satisfactory effects against depression and its clinical complications.…”

Section: Highlights Introductionmentioning

confidence: 99%

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

et al. 2020

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Depression is becoming a major public health concern worldwide. Si-Ni-San (SNS) is a famous formula in Traditional Chinese Medicine (TCM) with potent antidepressant effects. However, the antidepressant mechanism of SNS has not been clearly elucidated. This study was performed to verify whether the antidepressant effects of SNS were related to its anti-inflammatory effects, the levels of brain-derived neurotrophic factor (BDNF) and Cytochrome P450 (CYP450) enzymatic activity. In our study, behavioral tests such as the forced swim test, sucrose preference test and open-field test were evaluated to ensure the establishment of depressive rats. The levels of IL-1b, IL-6, and TNF-a in the serum, liver, and hippocampus of rats were measured by enzyme-linked immunosorbent assays (ELISA). Furthermore, the key proteins NF-kB, BDNF, and TrkB were analyzed by Western blot (WB) analysis in the hippocampus. In addition, CYP450 enzymatic activity analysis was performed using LC-MS/MS in conjunction with drug and statistics (DAS 3.0) after oral administration of six probe drugs. Our results showed that SNS attenuated reserpineinduced increases in IL-1b, IL-6, and TNF-a expression in the serum, liver, and hippocampus. The levels of NF-kB, BDNF, and TrkB in the hippocampus of depressive rats were also altered. According to the pharmacokinetic parameters, SNS had moderate inhibitory effects in the reserpine-induced depression model on CYP1A2, CYP2D1, CYP2E1, and CYP3A2, but no significant metabolic changes to CYP2C6 and CYP2D2. These findings suggested that SNS has a protective effect on reserpine-induced depressive rats, which may be related to the improvement of the inflammatory factors, the level of BDNF and the activity of CYP450 enzymes.

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“…Antidepressants, such as selective serotonin reuptake inhibitors, are the mainstay of pharmacological treatment for perinatal depression; fluvoxamine, paroxetine, and sertraline are preferred in breastfeeding women, leading to the lowest serum medication levels in infants ( Langan and Goodbred, 2016 ). According to a study conducted in the USA, about half of women diagnosed with postpartum depression are on antidepressant treatment ( Vu and Shaya, 2017 ). It is worth noting that treatment approaches for postpartum depression vary from region to region.…”

Section: Discussionmentioning

confidence: 99%

Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation

Esposito,

Cantarutti,

Lupattelli

et al. 2024

Front. Pharmacol.

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Background:Preterm birth may affect maternal mental health. We explored the relationship between preterm birth and the risk of initiating antidepressant use during the year after birth.Methods:We conducted a population-based investigation using regional healthcare utilization databases. The exposure considered was preterm birth. The outcome was having at least one prescription for antidepressant medications during the year after birth. We used a log-binomial regression model including terms for maternal age at birth, nationality, educational level, parity, modality of conception, modality of delivery, use of other psychotropic drugs, and diabetes to estimate relative risk (RR) and 95% confidence intervals (CI) for the association between preterm birth and the initiation of antidepressant use. In addition, the absolute risk differences (ARD) were also computed according to the timing of birth.Results:The cohort included 727,701 deliveries between 2010 and 2020 in Lombardy, Northern Italy. Out of these, 6,522 (0.9%) women had at least one prescription for antidepressant drugs during the year after birth. Preterm births were related to a 38% increased risk of initiation of antidepressant use during the year after birth (adjusted RR = 1.38; 95% CI: 1.25–1.52) for moderate to late preterm and to 83% (adjusted RR = 1.83; 95% CI: 1.46–2.28) for extremely and very preterm. Excluding women with only one antidepressant prescription, the association was consistent (adjusted RR = 1.41, 95%CI: 1.23–1.61 for moderate to late preterm and adjusted RR = 1.81, 95% CI: 1.31–2.49 for extremely and very preterm). Also, excluding women who used other psychotropics, the association remained consistent (adjusted RR = 1.39, 95%CI: 1.26–1.54 and adjusted RR = 1.91, 95% CI: 1.53–2.38, respectively for moderate to late and extremely and very preterm).Conclusion:Women who delivered preterm may have an excess risk of initiation of antidepressant consumption during the first year after birth.

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Predicting Factors of Depression, Antidepressant Use and Positive Response to Antidepressants in Perinatal and Postpartum Women

Cited by 10 publications

References 42 publications

Anxiety and Depression Among Women Living with HIV: Prevalence and Correlations

Anxiety and Depression Among Women Living with HIV: Prevalence and Correlations

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation

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