PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Abstract

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EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients

“…Cumulative experience supports the perception that prevention of inflammation and infection in patients with CLD is essential for improving survival. 1 , [46] , [47] , [48] Indeed, such patients are at high risk of hepatic decompensation and increased mortality and, in the case of SARS-CoV-2 infection, of the extrahepatic sequalae of severe COVID-19. 49 , 50 Of note, in the international registries SECURE-cirrhosis and COVID-Hep.net , hospitalised COVID-19 patients with cirrhosis had an overall case fatality rate of 38%, which was as high as 70% in Child-Pugh C patients, compared to 8% in non-cirrhotic patients, while mortality was similar in all age groups.…”

Reply to: Correspondence on ‘The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology’

“…In addition, the second investigation of the PREDICT study analyzed precipitating events in detail. 8 Precipitants, as well as complications attributed to severe portal hypertension, were more frequently found in unstable decompensated cirrhosis patients compared to the other phenotypes of acute decompensation.…”

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

“…In patients with alcoholic hepatitis (AH), the most florid form of ALD, the susceptibility to infection is further heightened and is the leading cause of death, with infection observed in up to 65% of cases ( Louvet et al, 2009 , 2015 ). It is also the commonest precipitating event for acute-on-chronic liver failure (ACLF) ( Arroyo et al, 2015 ; Trebicka et al, 2020 ).…”