Prediagnostic Intake of Dairy Products and Dietary Calcium and Colorectal Cancer Survival—Results from the EPIC Cohort Study

Dik, Vincent K.; Murphy, Neil; Siersema, Peter D.; Fedirko, Veronika; Jenab, Mazda; Kong, So Yeon; Hansen, Camilla Plambeck; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Dossus, Laure; Racine, Antoine; Bastide, Nadia; Li, Kuanrong; Kühn, Tilman; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Barbitsioti, Antonia; Palli, Domenico; Contiero, Paolo; Víneis, Paolo; Tumino, Rosario; Panico, Salvatore; Peeters, Petra H.M.; Weiderpass, Elisabete; Skeie, Guri; Hjartåker, Anette; Amiano, Pilar; Sánchez, María José; Fonseca-Nunes, Ana; Barricarte, Aurelio; Chirlaque, María Dolores; Redondo, María Luisa; Jirström, Karin; Manjer, Jonas; Wennberg, Maria; Bradbury, Kathryn E.; Khaw, Kay Tee; Wareham, Nicholas J.; Cross, Amanda J.; Riboli, Elio; Bueno-De-Mesquita, H. Bas

doi:10.1158/1055-9965.epi-14-0172

Cited by 37 publications

(41 citation statements)

References 42 publications

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“…The study population may not be entirely representative of the wider UK population, since all recruited participants were born in the county of Hertfordshire, were still living there in their eighth decade and were all Caucasian and therefore do not reflect the diversity of other populations in the UK. However, we have previously demonstrated that this cohort is representative of the general population with regard to anthropometric body build and lifestyle factors, such as smoking, alcohol intake and dietary calcium intake, which was in line with data found in the European Investigation into Cancer and Nutrition (EPIC) cohort [48], therefore suggesting that selection bias was minimal [17]. In addition, a 'healthy' responder bias is evident within the HCS [17]; however, it is unlikely to have affected the observed associations between sleep quality and bone parameters.…”

Section: Discussionsupporting

confidence: 89%

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

et al. 2020

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Sleep duration may be associated with risk of osteoporosis, with suggestions that too little or indeed too much sleep may be detrimental to bone health. In this study, we considered whether perceived sleep quality is also associated with bone health in older adults. We explored this association in a cohort of 443 older community-dwelling UK adults. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as > 5 on this score system. Bone density, shape and microarchitecture were assessed using dual energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HRpQCT). Thirty-seven percent of men and 43% of women had a PSQI score greater than 5, indicative of poor perceived sleep. We found that quality of sleep was associated with altered bone microarchitecture. In men, poor sleep quality was associated with lower radial trabecular (4% slice, p < 0.04) and cortical (66% slice, p = 0.02) bone mineral density, as well as decreased tibial cortical density (p < 0.02) and increased porosity (p < 0.04), but increased size of the tibia (p < 0.04). In women, poor perceived sleep quality was associated with thinner (p < 0.03) and less dense (p < 0.04) cortices of the radius, but greater tibial trabecular number (p < 0.02) and lower separation (p < 0.04). Relationships with DXA parameters were non-significant after adjustment for confounders. Taking sleep medications was associated with decreased tibial size (38% and 66% slices) and strength in women (all p < 0.05), but not in men. Perceived sleep quality was associated with altered bone density and microarchitecture in older adults, and these differences varied according to biological sex and site. Further work is indicated to investigate possible mechanisms underlying these observations.

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Section: Discussionsupporting

confidence: 89%

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

et al. 2020

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“…There is mixed evidence from prospective studies concerning a role of dairy food consumption in mortality risk (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Consistent with our results, in the Whitehall II Study (21), higher consumption of dairy products was associated with reduced all-cause mortality risk in comparison with the lowest intake.…”

Section: Discussionsupporting

confidence: 86%

“…Few epidemiologic studies have investigated whether a high dairy food intake is associated with cancer mortality risk (20,(27)(28)(29). While in the Michaëlsson et al study high milk intake was associated with higher cancer mortality risk in Swedish women but not men, there were no significant associations between cheese or yogurt and cancer mortality risk (20).…”

Section: Discussionmentioning

confidence: 98%

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Farvid¹,

Malekshah²,

Pourshams³

et al. 2017

American Journal of Epidemiology

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We investigated the association between dairy product consumption and all-cause, cardiovascular disease (CVD), and cancer mortality in the Golestan Cohort Study, a prospective cohort study launched in January 2004 in Golestan Province, northeastern Iran. A total of 42,403 men and women participated in the study and completed a diet questionnaire at enrollment. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. We documented 3,291 deaths (1,467 from CVD and 859 from cancer) during 11 years of follow-up (2004-2015). The highest quintile of total dairy product consumption (versus the lowest) was associated with 19% lower all-cause mortality risk (hazard ratio (HR) = 0.81, 95% confidence interval (CI): 0.72, 0.91; P trend = 0.006) and 28% lower CVD mortality risk (HR = 0.72, 95% CI: 0.60, 0.86; P trend = 0.005). High consumption of low-fat dairy food was associated with lower risk of all-cause (HR = 0.83, 95% CI: 0.73, 0.94; P trend = 0.002) and CVD (HR = 0.74, 95% CI: 0.61, 0.89; P trend = 0.001) mortality. We noted 11% lower all-cause mortality and 16% lower CVD mortality risk with high yogurt intake. Cheese intake was associated with 16% lower all-cause mortality and 26% lower CVD mortality risk. Higher intake of high-fat dairy food and milk was not associated with all-cause or CVD mortality. Neither intake of individual dairy products nor intake of total dairy products was significantly associated with overall cancer mortality. High consumption of dairy products, especially yogurt and cheese, may reduce the risk of overall and CVD mortality.

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“…Information on vital status and movement of participants was obtained through record linkage with the municipal and national mortality registries most countries or through a combination of methods, including health insurance records, cancer and pathology registries, and active follow-up of study subjects and their next-of-kin [26]. The outcome of the study was mortality (all-cause or breast cancer-specific).…”

Section: Methodsmentioning

confidence: 99%

Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Kyrø

Zamora-Ros

Scalbert

et al. 2015

Breast Cancer Res Treat

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The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status.

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Prediagnostic Intake of Dairy Products and Dietary Calcium and Colorectal Cancer Survival—Results from the EPIC Cohort Study

Cited by 37 publications

References 42 publications

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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