Preconception lifestyle advice for people with subfertility

Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

“…Although such interventions are recommended by experts, 4 there is currently no evidence from high-quality clinical trials that they improve pregnancy outcomes in obese women. 23 We left the choice of inducing withdrawal bleeding after an anovulatory cycle to the site investigator's discretion and found no adverse effect of withdrawal bleeding on fecundity, in contrast to the findings in our previous study. 2 , 24 Another potential weakness of the study is the relatively high dropout rate; however, it is similar to the dropout rate in the clomiphene group in our prior study (26%) 2 and to the rate in a similar multicenter trial involving 320 patients (19%).…”

Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

“…Although such interventions are recommended by experts, 4 there is currently no evidence from high-quality clinical trials that they improve pregnancy outcomes in obese women. 23 We left the choice of inducing withdrawal bleeding after an anovulatory cycle to the site investigator's discretion and found no adverse effect of withdrawal bleeding on fecundity, in contrast to the findings in our previous study. 2 , 24 Another potential weakness of the study is the relatively high dropout rate; however, it is similar to the dropout rate in the clomiphene group in our prior study (26%) 2 and to the rate in a similar multicenter trial involving 320 patients (19%).…”

Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females

“…Reverse causation has been observed in cross-sectional or case–control studies with retrospective diet assessment when subjects change their dietary behaviors in response to the diagnosis of medical conditions [ 33 , 34 , 35 , 36 ]. It is widely understood that lifestyle factors play a vital role in reproductive health [ 37 ], and there is a growing body of knowledge on the relationship between carbohydrate intake and fertility specifically [ 38 , 39 , 40 ]. It has been reported that patients presenting to fertility centers strongly seek information that may improve their fertility and partake in following a healthy lifestyle in the hope of improving their fertility treatment results [ 41 , 42 ].…”

Online Japanese-Language Information on Lifestyle Factors Associated With Reduced Fertility: Content Analysis

“…Fourth, it is possible that the selected lifestyle factors associated with reduced fertility may also have reflected our biases; however, this study examined several publications from academic societies, Cochrane Library, and previous studies to determine which lifestyle factors to investigate. For example, age was not treated as a lifestyle factor associated with reduced fertility in this study because Cochrane Library did not directly consider age when defining lifestyle factors that may both influence fertility and affect the chances of a healthy, live birth [ 5 ]. Additionally, a recent study found that most of the Japanese reproductive-aged population (60% to 70%) were knowledgeable about the association between age and reduced fertility [ 28 ].…”

Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

“…Although such interventions are recommended by experts, 4 there is currently no evidence from high-quality clinical trials that they improve pregnancy outcomes in obese women. 23 We left the choice of inducing withdrawal bleeding after an anovulatory cycle to the site investigator's discretion and found no adverse effect of withdrawal bleeding on fecundity, in contrast to the findings in our previous study. 2 , 24 Another potential weakness of the study is the relatively high dropout rate; however, it is similar to the dropout rate in the clomiphene group in our prior study (26%) 2 and to the rate in a similar multicenter trial involving 320 patients (19%).…”

Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females

“…Reverse causation has been observed in cross-sectional or case–control studies with retrospective diet assessment when subjects change their dietary behaviors in response to the diagnosis of medical conditions [ 33 , 34 , 35 , 36 ]. It is widely understood that lifestyle factors play a vital role in reproductive health [ 37 ], and there is a growing body of knowledge on the relationship between carbohydrate intake and fertility specifically [ 38 , 39 , 40 ]. It has been reported that patients presenting to fertility centers strongly seek information that may improve their fertility and partake in following a healthy lifestyle in the hope of improving their fertility treatment results [ 41 , 42 ].…”

Online Japanese-Language Information on Lifestyle Factors Associated With Reduced Fertility: Content Analysis

“…Fourth, it is possible that the selected lifestyle factors associated with reduced fertility may also have reflected our biases; however, this study examined several publications from academic societies, Cochrane Library, and previous studies to determine which lifestyle factors to investigate. For example, age was not treated as a lifestyle factor associated with reduced fertility in this study because Cochrane Library did not directly consider age when defining lifestyle factors that may both influence fertility and affect the chances of a healthy, live birth [ 5 ]. Additionally, a recent study found that most of the Japanese reproductive-aged population (60% to 70%) were knowledgeable about the association between age and reduced fertility [ 28 ].…”

Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

“…Although such interventions are recommended by experts, 4 there is currently no evidence from high-quality clinical trials that they improve pregnancy outcomes in obese women. 23 We left the choice of inducing withdrawal bleeding after an anovulatory cycle to the site investigator's discretion and found no adverse effect of withdrawal bleeding on fecundity, in contrast to the findings in our previous study. 2 , 24 Another potential weakness of the study is the relatively high dropout rate; however, it is similar to the dropout rate in the clomiphene group in our prior study (26%) 2 and to the rate in a similar multicenter trial involving 320 patients (19%).…”

Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females

“…Reverse causation has been observed in cross-sectional or case–control studies with retrospective diet assessment when subjects change their dietary behaviors in response to the diagnosis of medical conditions [ 33 , 34 , 35 , 36 ]. It is widely understood that lifestyle factors play a vital role in reproductive health [ 37 ], and there is a growing body of knowledge on the relationship between carbohydrate intake and fertility specifically [ 38 , 39 , 40 ]. It has been reported that patients presenting to fertility centers strongly seek information that may improve their fertility and partake in following a healthy lifestyle in the hope of improving their fertility treatment results [ 41 , 42 ].…”

Online Japanese-Language Information on Lifestyle Factors Associated With Reduced Fertility: Content Analysis

“…Fourth, it is possible that the selected lifestyle factors associated with reduced fertility may also have reflected our biases; however, this study examined several publications from academic societies, Cochrane Library, and previous studies to determine which lifestyle factors to investigate. For example, age was not treated as a lifestyle factor associated with reduced fertility in this study because Cochrane Library did not directly consider age when defining lifestyle factors that may both influence fertility and affect the chances of a healthy, live birth [ 5 ]. Additionally, a recent study found that most of the Japanese reproductive-aged population (60% to 70%) were knowledgeable about the association between age and reduced fertility [ 28 ].…”