Preclinical Experience With Iotroliotrol Myelography

Muetzel, W.; Press, Wolf-Rüdiger; Weinmann, Hanns‐Joachim; Drayer, Burton P.; Ross, Michael; Allen, Susan; Bates, Milton

doi:10.1097/00004424-198407001-00058

Cited by 5 publications

(2 citation statements)

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“…Iotrolan (Isovist ® , Schering), a third generation nonionic dimeric CM is extremely hydrophylic, stable in aqueous solution, and has similar to cerebrospinal fluid (CSF) tonicity at 300 mgI/ml. Iotrolan has a long opacification time and possibly is less neurotoxic than the other media used in dogs (WIDMER and BLEVINS, 1991;VAN BREE et al, 1991) and humans (MUETZEL et al, 1984;HAMMER and DEISENHAMMER, 1985).…”

Section: Introductionmentioning

confidence: 99%

Absence of Postmyelographic Adverse Effects and High Radiographic Resolution of Iotrolan Used in the Cervical Myelography for the Clinically Normal Cat: An Open‐Placebo Controlled Study

Patsikas¹,

Polizopoulou²,

Koutinas³

et al. 1999

Journal of Veterinary Medicine Series A

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Iotrolan solution at 300 mgI/ml (Isovist® 300, Schering AG), was injected into the cerebromedullary cistern in 8 cats (Isovist group), at a volume of 0.5 ml/Kg BW and over one minute. In 3 cats (control group), normal saline was also injected at a same volume and speed. During the subarachnoid injection and at 1, 5 and 10 min thereafter all the cats were being monitored for evidence of respiratory arrest, bradycardia or changes in the arterial blood pressure. The cats were also checked for postmyelographic adverse effects for at least 3 h after their complete recovery from anaesthesia. Postmyelographic neurologic examination was done for 3 consecutive days and the myelographic quality of the films taken at 5 and 15 min postinjection was evaluated. No significant differences were detected between the Isovist and the control groups for all the variables evaluated immediately before, during and up to 3 days after the injection. No actual postmyelographic adverse effects were seen in the animals of both groups. At 15 and 30 min postinjection the opacity, the distention of the subarachnoid space and the detail of all the myelograms obtained were assessed as highly diagnostic.

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Section: Introductionmentioning

confidence: 99%

Absence of Postmyelographic Adverse Effects and High Radiographic Resolution of Iotrolan Used in the Cervical Myelography for the Clinically Normal Cat: An Open‐Placebo Controlled Study

Patsikas¹,

Polizopoulou²,

Koutinas³

et al. 1999

Journal of Veterinary Medicine Series A

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“…Clinical abnormalities, cerebrospinal fluid (CSF) changes and meningeal reaction following myelography are mainly related to the neurotoxic effects of contrast media (CM). Iotrolan (Isovist ® , Schering AG, Athens, Greece), a third generation nonionic dimeric CM, has longer opacification time and is less neurotoxic than the other CM used for human (Muetzel et al, 1984;Hammer and Deisenhammer, 1985;Wenzel-Hora, 1987;Wagner et al, 1994) or animal myelography (Press et al, 1989;Van Bree et al, 1991;Widmer and Blevins, 1991;Skalpe and Tang, 1995;Patsikas et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Absence of Cerebrospinal Fluid Abnormalities and Spinal Cord Lesions after Iotrolan Cervical Myelography in Normal Cats: An Open Placebo‐Controlled Study

Patsikas¹,

Koutinas²,

Vlemas

et al. 1999

Journal of Veterinary Medicine Series A

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Iotrolan (Isovist ® 300, Schering AG) at a volume of 0.5 ml/kg B.W. was injected into the cerebellomedullary cistern of 12 cats (Isovist group); the same volume of normal saline was injected in four other cats (control group). Two ml of CSF was collected from each anaesthetized cat by cisternal tap immediately before, and 7 and 15 days after, injection. The physical characteristics, specific gravity, total cell count and total protein concentration of each CSF sample were recorded. The cats were euthanized on day 15 immediately after CSF samples and spinal cord specimens had been obtained. Spinal cord histopathology was examined with the aid of light and transmission electron microscopy.The physical characteristics of all the CSF samples were within the reference range. No significant differences were found for CSF specific gravity, total cell count and total protein concentration between the pre-injection samples and those collected 7 and 15 days post-injection in both groups; no spinal cord lesions were detected in histopathology.

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Contrast Media and the Central Nervous System

Dawson¹

1990

Clinical Medicine and the Nervous System

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Preclinical Experience With Iotroliotrol Myelography

Cited by 5 publications

References 0 publications

Absence of Postmyelographic Adverse Effects and High Radiographic Resolution of Iotrolan Used in the Cervical Myelography for the Clinically Normal Cat: An Open‐Placebo Controlled Study

Absence of Postmyelographic Adverse Effects and High Radiographic Resolution of Iotrolan Used in the Cervical Myelography for the Clinically Normal Cat: An Open‐Placebo Controlled Study

Absence of Cerebrospinal Fluid Abnormalities and Spinal Cord Lesions after Iotrolan Cervical Myelography in Normal Cats: An Open Placebo‐Controlled Study

Contrast Media and the Central Nervous System

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