2010
DOI: 10.1158/0008-5472.can-10-3001
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Abstract: In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division.

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Cited by 109 publications
(125 citation statements)
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References 38 publications
(42 reference statements)
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“…We previously reported that AMG 900 was active in P-gp-expressing cancer cell lines resistant to taxanes and three well-characterized Aurora kinase inhibitors (18). To further investigate these findings, we used the highly metastatic MDA-MB-231 ( ( Supplementary Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…We previously reported that AMG 900 was active in P-gp-expressing cancer cell lines resistant to taxanes and three well-characterized Aurora kinase inhibitors (18). To further investigate these findings, we used the highly metastatic MDA-MB-231 ( ( Supplementary Fig.…”
Section: Resultsmentioning
confidence: 99%
“…It is important to recognize the potential challenge of combining AMG 900 with other MTAs in the clinic due to the likelihood of overlapping toxicities in proliferating tissues (e.g., bone marrow and gastrointestinal mucosa). The negative impact on normal tissue homeostasis could limit the utility of this combination, although prophylactic administration of granulocyte colony-stimulating factor may help decrease the duration of neutropenia (18). One area for further investigation will be to evaluate the activity of AMG 900 alone and in combination with MTAs in either patientderived cancer xenografts or a genetically engineered mouse model of human MBC (37,38).…”
Section: Discussionmentioning
confidence: 99%
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“…The measurement of Rho123 (Sigma) accumulation was performed by the flow cytometric assay (FCM). In brief, cells (5x10 5 per sample) were incubated with 10 µmol/l of Rho123 in the dark at 37˚C in 5% CO 2 for 180 min. Verapamil (10 µmol/l) was then added to the cultures at the same time as Rho123.…”
Section: Methodsmentioning
confidence: 99%
“…Expression of Aurora C is restricted to germ cells, in which it is believed to regulate spermatogenesis. Aurora kinase A is an oncogene frequently elevated in human cancers and is associated with advanced clinical staging and poor survival (5). Currently, a variety of ATP-competitive inhibitors that target Aurora kinases and possess varying degrees of kinase specificity are utilized in early clinical development (6).…”
Section: Introductionmentioning
confidence: 99%